Vitamin D status in gastrointestinal and liver disease

Pappa, Helen; Bern, Elana; Kamin, Daniel; Grand, Richard J.

doi:10.1097/mog.0b013e3282f4d2f3

Cited by 74 publications

(49 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vitamin D is hydroxylated by liver to 25-hydroxy vitamin D, the main circulating form, and then is converted into the active form 1, 25-dihydroxyvitamin D in kidney [1,2]. Given that liver is involved in bile salt production, absorption of vitamin D, and 25-hydroxylation of vitamin D, it might be expected that vitamin D deficiency would be common in patients with chronic liver disease (CLD) [2].…”

Section: Introductionmentioning

confidence: 99%

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

et al. 2010

View full text Add to dashboard Cite

Purpose Liver has an important role in metabolism of vitamin D. This study aimed to evaluate the patterns of vitamin D-parathyroid hormone (PTH) disturbance and correlate it in patients with non-cholestatic chronic liver disease (CLD). Methods A total of 40 healthy controls and 90 consecutive patients with evidence of non-cholestatic CLD due to hepatitis C (n = 28), hepatitis B (n = 26), autoimmune hepatitis (n = 19), and cryptogenic causes (n = 17) were enrolled. Cirrhosis was evident in 51 patients. Serum concentrations of 25-hydroxy vitamin D, PTH, calcium, phosphate, and liver enzymes were measured. Child-Pugh classification was determined in cirrhotic patients. Results Vitamin D deficiency (\50 nmol/l) was found in 46 (51.1%) patients and vitamin D insufficiency (50-80 nmol/l) in 15 (16.7%) patients. Secondary hyperparathyroidism (serum PTH [ 6.8 pmol/l) was present in 6 (6.7%) patients. The prevalence of vitamin D deficiency was significantly higher in cirrhotic versus noncirrhotic patients (76.5 vs. 17.9%; P \ 0.001), whereas there was no significant difference in serum calcium, phosphate, and PTH levels. ChildPugh class B and C patients had significantly lower vitamin D level compared with class A patients (P \ 0.001), whereas there was no significant difference in serum calcium, phosphate, and PTH levels. No significant correlation was seen between vitamin D and PTH, calcium or phosphate levels. Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia. Conclusions Vitamin D inadequacy and the severity of liver dysfunction move in parallel in patients with noncholestatic CLD. Vitamin D assessment and replacement should be considered in the management of patients with non-cholestatic CLD.

show abstract

Section: Introductionmentioning

confidence: 99%

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In cholestatic liver disease, there is a decrease in the intestinal availability of bile salts. This results in malabsorption of fat-soluble vitamins such as vitamin D 43 .…”

Section: Liver Diseasementioning

confidence: 99%

Hypovitaminosis D in Adult - A systemic Review

Islam¹,

Amin

2017

Bangla J Med

View full text Add to dashboard Cite

“…Vitamin D deficiency has also been associated with various other diseases, including multiple sclerosis, 40 asthma, 41 schizophrenia, 42 gastrointestinal and liver disease 43 and dementia. 44 So how much is enough?…”

Section: Rheumatologic Diseasesmentioning

confidence: 99%

An interesting D-lemma: what is all the excitement about vitamin D?

Conradie

Ascott-Evans

2013

South African Family Practice

View full text Add to dashboard Cite

There has been a dramatic interest in the importance of vitamin D, "the sunshine vitamin", in the past few years with regard to its impact on various aspects of health and disease. Research into well-known skeletal effects, as well as extra-skeletal effects, has been overwhelming. At times it has been difficult to make informed clinical decisions regarding replacement, if needed at all. This article aims to provide the family practitioner with a summary of the most important clinical effects of vitamin D, as well as give guidelines on testing for possible deficiency and consideration of replacement thereof.Peer reviewed.

show abstract

Vitamin D status in gastrointestinal and liver disease

Cited by 74 publications

References 128 publications

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

Hypovitaminosis D in Adult - A systemic Review

An interesting D-lemma: what is all the excitement about vitamin D?

Contact Info

Product

Resources

About