Vitamin D status in children and adolescents with autoimmune thyroiditis

Abstract

Low serum vitamin D is significantly associated with AIT in Egyptian children. However, vitamin D level is not an independent risk for the progression of AIT to overt hypothyroidism. BMI may have an influence on serum 25OHD levels.

Serum vitamin D level is related to disease severity in pediatric alopecia areata

“…[6][7][8][9][10] Also, relation of vitamin D deficiency and autoimmune diseases including type 1 diabetes mellitus, systemic lupus erythematosus, autoimmune thyroiditis, and juvenile dermatomyositis has been researched in pediatric population. [12][13][14][15][16][17] Although there is lack of studies addressing role of vitamin D in pediatric AA, which is an autoimmune disease of the hair follicle, the relationship between vitamin D deficiency and AA in adult patients has been investigated. 6 Supporting our findings, it was reported in previous studies that topical or systemic administration of vitamin D analogs was detected as an effective agent in the progression of hair loss, and protective against the factors inducing hair loss.…”

“…Recently, many studies have reported associations between vitamin D deficiency and a higher incidence of autoimmune disorders in adults such as RA, SLE, psoriasis, vitiligo, MS, IBD, and Behcet disease . Also, relation of vitamin D deficiency and autoimmune diseases including type 1 diabetes mellitus, systemic lupus erythematosus, autoimmune thyroiditis, and juvenile dermatomyositis has been researched in pediatric population …”

“…Although 1,25(OH)2D3 is biologically active form, 25‐hydroxyvitamin D (25[OH]D) better reflects the all sources of vitamin D exposure and is a stable indicator to predict vitamin D status . Recent studies which have revealed connection between autoimmune diseases, including type I DM, RA, SLE, vitiligo, psoriasis, multiple sclerosis (MS), inflammatory bowel disease (IBD), and vitamin D deficiency suggest that vitamin D deficiency might be an environmental trigger for the induction of autoimmunity …”

“…AA is considered an autoimmune disease and occurs with various autoimmune disorders, such as rheumatoid arthritis (RA), type I diabetes mellitus (DM), vitiligo, systemic lupus erythematosus (SLE), thyroiditis, pemphigus vulgaris, pernicious anemia, and celiac disease. 1,2 Besides playing an important role in calcium homeostasis and [6][7][8][9][10][11][12][13][14][15][16][17] The relationship between vitamin D deficiency and AA in adults was reported previously in studies; however, this relationship has not been evaluated comprehensively in pediatric population. In this study, we investigated vitamin D status in AA and its relationship with disease severity, number of patches, and disease duration.…”

Vitamin D and autoimmune thyroid diseases

“…On the other hand, serum calcidiol correlated positively with FT4 levels. However, after adjustment for other potential confounding factors; age, sex and BMI, 25(OH)D 3 concentration was not an independent risk factor for the progression of subclinical to overt hypothyroidism (56).…”