Vitamin D status in children and young adults with perinatally acquired HIV infection

Rutstein, Richard M.; Downes, Alison; Zemel, Babette S.; Schall, Joan I.; Stallings, Virginia A.

doi:10.1016/j.clnu.2011.02.005

Cited by 54 publications

(63 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Subjects receiving tenofovir did not differ at baseline or in the change in 25 In a few studies evaluating children and young adults with HIV infection, researchers found a high prevalence of suboptimal 25(OH)D, ranging from 71% to 89% <30 ng/mL [3,[26][27][28]] to 33% to 78% <20 ng/mL [1,4,[29][30][31], with 1 group reporting 87% <15 ng/mL [2]. Our results support the finding that suboptimal 25(OH)D status is common in unsupplemented youth, with 95% at baseline having a 25(OH)D <32 ng/mL.…”

Section: Resultsmentioning

confidence: 99%

Safety and Efficacy of High-Dose Daily Vitamin D3 Supplementation in Children and Young Adults Infected With Human Immunodeficiency Virus

Dougherty

Schall

Zemel

et al. 2014

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

Background. Suboptimal vitamin D (vitD) status is common in children and young adults infected with human immunodeficiency virus (HIV). The vitD supplemental dose needed to normalize vitD status in this population is unknown. Methods. In this double-blind trial, subjects infected with HIV ages 8.3 to 24.9 years were randomized to vitD 3 supplementation of 4000 IU/day or 7000 IU/day and evaluated at 6 and 12 week for changes in vitD status and HIV indicators. A dose was considered unsafe if serum calcium was elevated (above age and sex-specific range) associated with elevated serum 25 hydroxyvitamin D (25(OH)D); >160 ng/mL). Results. At baseline, 95% of subjects (n = 44; 43% with perinatally acquired HIV, 57% with behaviorally acquired HIV) had a suboptimal serum 25(OH)D concentration of <32 ng/mL (mean ± standard deviation, 19.3 ± 7.4; range, 4.4-33.6 ng/mL). After 12 weeks (main outcome) of D 3 supplementation, both D 3 doses were safe and well tolerated, with no evidence of elevation of serum calcium concentrations or deterioration in HIV immunologic or virologic status. Sufficient vitD status, defined as serum 25(OH)D 32 ng/mL, was achieved in 81% of all subjects, and only the 7000 IU/day group (86%) achieved this a priori efficacy criterion in >80% of subjects. Change in serum 25(OH)D did not differ between HIV acquisition groups. Conclusions. A 7000 IU/day D 3 supplementation was safe and effective in children and young adults infected with HIV.

show abstract

Section: Resultsmentioning

confidence: 99%

Safety and Efficacy of High-Dose Daily Vitamin D3 Supplementation in Children and Young Adults Infected With Human Immunodeficiency Virus

Dougherty

Schall

Zemel

et al. 2014

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

show abstract

“…9,23,25,27,30,31,34,42,60 The reasons for such disagreement may lie in the study designs, particularly in the sampling of controls. In six out of nine studies controls were not age-matched to cases, 9,23,25,31,42,60 and that is exceptionally important, since older age is an established risk factor for low vitamin D concentrations. 64,65 The three age-and sex-matched studies had other important limitations, which have been already emphasized.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

“…27,31,41 Considering other HIV-related risk factors, patchy correlations were found between HIV viral load, duration of ART, duration of HIV, plasma neopterin, or soluble tumor necrosis factor-alpha receptor I and vitamin D deficiency. 6,8,9,23,25,28,37,52,54,57 Adverse health outcomes related to vitamin D deficiency in HIV-infected patients Very few studies investigated the detrimental effects of vitamin D deficiency on health outcomes other than bone diseases in HIV+. They were primarily cross-sectional correlation analyses, and it was therefore not possible to establish a cause-effect relationship.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

“…Even the data collected and the methods used to report the information were quite variable (eg, age and duration of ART therapy were described as mean ± standard deviation, median with interquartile range, or range). Most of the articles described adult or young adult patients; two were undertaken in children or adolescents; 25,44 while one RCT was performed in pregnant women. 41 The proportion of subjects of Caucasian ethnicity varied from 0% to 100%, as well as the percentage of women.…”

Section: Literature Searchmentioning

confidence: 99%

“…The vast majority of studies were performed in Europe and the United States (28 articles), and most of them were crosssectional analyses. Nine studies compared vitamin D status between HIV+ and "healthy" subjects, 9,23,25,27,30,31,34,42,60 but only three of them were matched case-control analyses. 27,30,34 Overall, the studies were heterogeneous in terms of demographic and clinical characteristics of populations included.…”

Section: Literature Searchmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D deficiency in HIV-infected patients: a systematic review

Giusti¹,

Penco²,

Pioli³

2011

NDS

View full text Add to dashboard Cite

Advances in the diagnosis and management of human immunodeficiency virus (HIV) have resulted in a dramatic decrease in mortality in HIV-infected individuals (HIV+). The subsequent increase in life expectancy of HIV+ has led to the need to consider the long-term complications of the disease and its treatment. Abnormalities in vitamin D status and metabolism are increasingly recognized as a major concern in HIV infection. In the last 5 years a number of cross-sectional and prospective studies have suggested a high prevalence of vitamin D deficiency in HIV+. Although few case-control studies have been published, it has been suggested that the prevalence of hypovitaminosis D in HIV+ is higher than in the general population, and at least in part, is related to the course of the disease and/or the antiretroviral drugs used to treat the disease. An adequate vitamin D status is important not only for bone tissue, but also for the global health status of HIV+ individuals, since a growing body of evidence has demonstrated the detrimental effects of vitamin D deficiency on multiple health outcomes. Therefore, definition of the size of the problem and identification of effective protocols for the prevention and management of vitamin D deficiency in HIV+ patients represent important steps in improving health status and reducing long-term chronic complications in individuals with HIV. Due to its immunomodulatory effects, vitamin D may also have implications in the progression of HIV infection. This systematic review was designed to determine the prevalence of vitamin D deficiency in HIV+ patients; to identify risk factors (related to the HIV infection or not) potentially associated with this condition; to describe the potential consequences of hypovitaminosis D on the course of the infection and the benefits of vitamin D repletion; and to make some suggestions about the future, considering the limitations of previous studies.

show abstract

The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

238

230

View full text Add to dashboard Cite

Summary The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti‐viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti‐viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

show abstract

Vitamin D status in children and young adults with perinatally acquired HIV infection

Cited by 54 publications

References 26 publications

Safety and Efficacy of High-Dose Daily Vitamin D3 Supplementation in Children and Young Adults Infected With Human Immunodeficiency Virus

Safety and Efficacy of High-Dose Daily Vitamin D3 Supplementation in Children and Young Adults Infected With Human Immunodeficiency Virus

Vitamin D deficiency in HIV-infected patients: a systematic review

The interplay between vitamin D and viral infections

Contact Info

Product

Resources

About