Vitamin D status during pregnancy and in cord blood in a large prospective French cohort

Courbebaisse, Marie; Souberbielle, Jean‐Claude; Baptiste, Amandine; Taieb, Julien; Tsatsaris, Vassilis; Gadrey, Jean; Sénat, Marie-Victoire; Haidar, Hazar; Jani, Jacques; Guizani, Meriem; Jouannic, Jean‐Marie; Haguet, Marie-Clotilde; Winer, Norbert; Masson, Damien; Elie, Caroline; Benachi, Alexandra

doi:10.1016/j.clnu.2018.08.035

Cited by 19 publications

(16 citation statements)

References 38 publications

(75 reference statements)

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“…Our study has several strengths. We used data from a large multicentre prospective cohort explicitly designed to investigate the association between maternal vitamin D concentrations and perinatal outcomes [27,28]. All pregnant women had a blood draw between 10 and 14 weeks of gestation, as opposed to other studies that used wide gestational age limits for the assessment of 25-ODH concentrations [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…All pregnant women had a blood draw between 10 and 14 weeks of gestation, as opposed to other studies that used wide gestational age limits for the assessment of 25-ODH concentrations [12][13][14]. France and Belgium have a temperate climate and variability in sun exposure was also limited because participating centres were at similar latitudes [27]. Also, in contrast to many previous analyses, we had standardised measures of skin color.…”

Section: Discussionmentioning

confidence: 99%

“…The FEPED study is an observational prospective cohort conducted from April 2012 through July 2014 in five French and one Belgium maternity units [27,28]. The primary aim of this study was to assess the prevalence of vitamin D deficiency over the course of pregnancy and the association between vitamin D concentrations and preeclampsia [28].…”

Section: Methodsmentioning

confidence: 99%

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First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

et al. 2019

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Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

et al. 2019

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“…Our results show lower vitamin D levels during the winter/spring months, and a higher risk of vitamin D deficiency and insufficiency, which is in accordance with previous studies conducted in our country 12,13 . The association of BMI with vitamin D status has been analysed in many countries, although the results have been inconsistent 10,12,13,44,45 . We found that pregnant women with excess weight (BMI ≥ 25 kg/m 2 ) had lower circulating 25(OH)D and a greater probability of presenting lower vitamin D status.…”

Section: Discussionmentioning

confidence: 99%

“…in pregnant women varies among European countries and Mediterranean regions with different dietary and lifestyle habits or non-modifiable (genetics) factors 10,11 . Therefore, determining the mother's vitamin D status in early pregnancy and associated factors is essential if strategies are to be developed for preventing/controlling this serious pandemic health problem and guiding future public health policies.…”

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Prevalence and risk factors of hypovitaminosis D in pregnant Spanish women

Díaz‐López

Jardí

Villalobos

et al. 2020

Sci Rep

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The hypovitaminosis D epidemic is a global health problem. Our aim was to assess the prevalence and potential risk factors of hypovitaminosis D among pregnant women on the eastern Mediterranean coast. Cross-sectional analysis involved 793 healthy pregnant women (35.3 ± 5.0 years) participating in ECLIPSES, a multicenter randomized trial. Socio-demographic, obstetric, anthropometric, lifestyle, dietary variables and blood draw was collected in the first trimester. Vitamin D deficiency was identified in 50.2% and insufficiency in 30.3% of pregnant women. The mean vitamin D level in the overall sample was 33.9 nmol/L (SD, 17.0). Multivariable logistic regression analysis applying AIC-based backward selection identified excess weight during the 1st trimester (BMI ≥ 25 kg/m2) (OR = 1.950, 95% CI = 1.409, 2.699), Arab ethnic group/dark skin colour (OR = 4.005, 95% CI = 2.488, 6.447), winter/spring (OR = 4.319, 95% CI = 3.112, 5.994), and consumption of milk (OR = 0.754, 95% CI = 0.572, 0.993) and yogurt (OR = 0.635, 95% CI = 0.436, 0.922) as independent risk factors for vitamin D deficiency. All of these factors (except yogurt consumption) and physical activity were independently associated with vitamin D deficiency/insufficiency risk in the final multivariable model (all p < 0.05). All these factors and social class were the most important determinants of circulating 25(OH)D concentrations. Our results confirm a high prevalence of vitamin D deficiency and insufficiency among pregnant women from the eastern Mediterranean coast.

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Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study

et al. 2021

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Vitamin D status during pregnancy and in cord blood in a large prospective French cohort

Cited by 19 publications

References 38 publications

First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

Prevalence and risk factors of hypovitaminosis D in pregnant Spanish women

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study

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