Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort

Munger, Kassandra L.; Åivo, Julia; Hongell, Kira; Soilu‐Hänninen, Merja; Surcel, Heljä Marja; Ascherio, Alberto

doi:10.1001/jamaneurol.2015.4800

Cited by 152 publications

(113 citation statements)

References 18 publications

(22 reference statements)

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“…3,14,15,17 Furthermore, direct measurements of in utero levels of D vitamin are not possible, meaning that the above association has only been addressed using different markers of fetal vitamin D levels, including maternal intake of vitamin D 14 during pregnancy, maternal serum levels of 25(OH)D during pregnancy, 3,17 or neonatal levels of vitamin D.…”

Section: (Ohmentioning

confidence: 99%

“…15,16 In contrast, in a recent study in the Finnish Maternity Cohort, maternal vitamin D deficiency (serum 25[OH]D levels ,30 nmol/L) in early pregnancy was associated with a 90% increase in risk of MS in the offspring. 17 Here, we examine the association between neonatal 25(OH)D status and risk of MS in a large population-based case-control study using data from the nationwide Danish MS registry and the Danish Newborn Screening Biobank (DNSB).…”

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confidence: 99%

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Neonatal vitamin D status and risk of multiple sclerosis

et al. 2017

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Objective: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. Methods:We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank.

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Section: (Ohmentioning

confidence: 99%

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confidence: 99%

Neonatal vitamin D status and risk of multiple sclerosis

et al. 2017

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“…These results suggest that MS risk is related not only to recent vitamin D levels, but it might be also related on its levels during childhood or even in utero. Several studies including a meta-analysis demonstrated that spring-borns have a significant higher lifetime MS risk than autumn-borns, which has been attributed at least in part to an insufficient in utero vitamin D levels because of low maternal serum vitamin D levels during winter [93][94]. In a large population-based case-control study [95], children born with 25(OH)D levels <10 ng/mL seemed to be at a high risk of developing MS.…”

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confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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“…In conclusion, despite all these uncertainties, the authors suggested that vitamin D replacement during pregnancy may decrease the risk of MS in offspring (1).…”

Section: Tuncay Gündüzmentioning

confidence: 94%

“…However, a relatively lower number of studies have found an increased risk of MS with exposure to low vitamin D levels in utero, and some studies reported no effect (1).…”

Section: Tuncay Gündüzmentioning

confidence: 99%

Does Serum Vitamin D Level During Pregnancy Influence the Risk of Multiple Sclerosis?

Gündüz¹

2016

tnd

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The increased risk of multiple sclerosis (MS) in adults with low vitamin D levels has been demonstrated previously in a large number of studies. However, a relatively lower number of studies have found an increased risk of MS with exposure to low vitamin D levels in utero, and some studies reported no effect (1).A recent study by Munger et al.(1) used all serum samples taken from all pregnant women for routine tests and preserved since 1983 (Finnish Maternity Cohort). MS was diagnosed in 193 patients who were born between 1983-1991, serum 25(OH)D levels of their mothers were assessed using "chemiluminescence microparticle immunoassays", and results were compared with 326 mothers who had normal babies and were matched with the study group according to age and demographic features.Analysis of the data revealed that 70% of the samples were taken before the 12 th week of pregnancy and 99% were taken before the 28 th week of pregnancy. Strikingly, children of mothers who were detected to have low vitamin D level (<12.02 ng/mL) at early periods of pregnancy had 90% higher risk of developing MS.The strengths of this study include its population-based nature, which minimized its selection bias. However, these results do not give an idea about later months of pregnancy because the samples were mostly taken during the first trimester. Also, lower vitamin D levels in maternal blood sample do not always mean lower fetal vitamin D level. In addition, low vitamin D levels after birth in children who developed MS might have been responsible for the increased risk of MS.In conclusion, despite all these uncertainties, the authors suggested that vitamin D replacement during pregnancy may decrease the risk of MS in offspring (1). Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si: Tuncay Gündüz MD,

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Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort

Cited by 152 publications

References 18 publications

Neonatal vitamin D status and risk of multiple sclerosis

Neonatal vitamin D status and risk of multiple sclerosis

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Does Serum Vitamin D Level During Pregnancy Influence the Risk of Multiple Sclerosis?

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