Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection

Kitson, Matthew T.; Dore, Gregory J.; George, Jacob; Button, Peter; McCaughan, Geoffrey W.; Crawford, Darrell H. G.; Sievert, William; Weltman, Martin; Cheng, Wendy; Roberts, Stuart K.

doi:10.1016/j.jhep.2012.11.017

Cited by 76 publications

(115 citation statements)

References 22 publications

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“…A lower serum 25(OH) D level significantly correlates with an increasing risk of advanced fibrosis and a higher severity of necroinflammatory activity has been related to different populations with individuals infected with chronic hepatitis C (Lange et al, 2011;Kitson et al, 2013;Petta et al, 2013). However, the results are not consistent in different studies and by race (Kitson et al, 2013;White et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The risk factors like older age, consumption of alcohol, metabolic alterations, liver necroinflammation, duration of infection and viral co-infections (Poynard et al, 2003), and insulin resistance (Romero-Gómez et al, 2005) can influence the degree of liver fibrosis. More and more evidence also shows that vitamin D status is very important for the liver disease severity in patients who are infected with chronic hepatitis C (Terrier et al, 2012;Kitson et al, 2013;Ladero et al, 2013;Lange et al, 2013 (VDBP). Because the half-life of serum 25(OH) D is long, the serum concentration of 25(OH) D is the most commonly used biomarker for vitamin D status (Wang et al, 2004;Stokes et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Luo

Ling

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior to October 2013 with no restrictions. We included group studies that reported odds ratio (OR) estimates with 95% confidence intervals (CIs) or a mean with standard deviation (SD) for the association between serum vitamin D status and the severity of liver fibrosis in chronic hepatitis C patients. Approximately 8321 participants from several countries were included in this analysis. Six studies on serum vitamin D status and the severity of liver fibrosis were included in this meta-analysis. ORs with 95% CIs were extracted from four studies and the pooled ORs were 0.866 (95% CI, 0.649 to 1.157). The means with SDs were extracted from three studies and the pooled means were −0.487 (95% CI, −0.659 to −0.315). There was statistically significant heterogeneity among the mean data extracted studies (P=0.029; I 2 =71.8%) but not among the OR data extracted studies (P=0.061; I 2 =55.6%). Finally, results from the mean data extracted studies suggest that lower serum vitamin D is a risk factor for the severity of liver fibrosis in chronic hepatitis C patients. However, there is no conclusive evidence on this association because of inconsistencies between the OR data extracted studies and the mean data extracted studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Luo

Ling

et al. 2014

J. Zhejiang Univ. Sci. B

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“…Thus, vitamin D deficiency could contribute to a (5) . On the other hand, Kitson et al (13) and Bitetto et al (4) did not find association between vitamin D serum levels and the degree of liver fibrosis in their studies, in which the contribuiting factors were not clear, with chances of being racial, genetic or methodological differences used in vitamin D analysis. It should be questioned if vitamin D deficiency increases with age and the patients included in the present study should be quite young to assess this relationship.…”

Section: Discussionmentioning

confidence: 85%

“…An independent association between low vitamin D serum level and higher degree of inflammatory activity has been suggested (4,13) . A probable explanation for the association between lower vitamin D levels and lower inflammatory activity in the liver would be the decrease of 25-hydroxylase activity, promoting decrease in vitamin D hydroxylation activity and, hence, lower serum levels (13) .…”

Section: Discussionmentioning

confidence: 99%

“…A probable explanation for the association between lower vitamin D levels and lower inflammatory activity in the liver would be the decrease of 25-hydroxylase activity, promoting decrease in vitamin D hydroxylation activity and, hence, lower serum levels (13) . However, this association was not observed in this study, corroborating Petta et al's findings (20) , putting in question this potential mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

Oliveira

Buss

Tovo

2017

Arq. Gastroenterol.

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BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

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Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients

et al. 2013

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Vitamin D is an important immune modulator that plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B (CHB) is less well characterized. Therefore, we quantified 25(OH)D 3 serum levels in a cohort of 203 treatmentna€ ıve patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of CHB. Of 203 patients, 69 (34%), 95 (47%), and 39 (19%) had severe vitamin D deficiency (25(OH)D 3 <10 ng/mL), vitamin D insufficiency (25(OH)D 3 10 and <20 ng/mL), or adequate vitamin D serum levels (25(OH)D 3 20 ng/mL), respectively. In both uni-and multivariate analyses, HBV DNA viral load (log 10 IU/mL) was a strong predictor of low 25(OH)D 3 serum levels (P 5 0.0007 and P 5 0.000048, respectively) and vice versa. Mean 25(OH)D 3 serum concentrations in patients with HBV DNA <2,000 versus 2,000 IU/mL were 17 versus 11 ng/mL, respectively (P < 0.00001). In addition, hepatitis B early antigen (HBeAg)-positive patients had lower 25(OH)D 3 serum levels than HBeAg-negative patients (P 5 0.0013). Finally, 25(OH)D 3 and HBV DNA serum levels showed inverse seasonal fluctuations. Conclusion: Low 25(OH)D 3 serum levels are associated with high levels of HBV replication in patients with CHB. This represents a major difference from chronic hepatitis C, where numerous previous studies have shown a lack of correlation between HCV viral load and vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D 3 and HBV DNA serum levels are suggestive of a functional relationship between both variables. (HEPATOLOGY 2013;58:1270-1276

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Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection

Cited by 76 publications

References 22 publications

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients

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