Vitamin D status and vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Egyptian children

Abd-Allah, Somia H.; Pasha, Heba F.; Hagrass, Hoda A.; Alghobashy, Ashgan Abdallah

doi:10.1016/j.gene.2013.12.032

Cited by 55 publications

(71 citation statements)

References 42 publications

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“…In addition, vitamin D has non-skeletal functions including cardiovascular, metabolic, and most importantly, immune-modulatory effects2627. Indeed, a 25-OH-D level lower than 20 ng/ml confers increased risk of immune disorders such as type 1 DM and multiple sclerosis2829. Because vitamin D receptors (VDRs) reside in neutrophils, T-cells and antigen-presenting cells (APCs)30, and vitamin D exerts its action through VDRs, vitamin D would be expected to participate in the regulation of immunity.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels are positively associated with varicella zoster immunity in chronic dialysis patients

Chao

Lee

Yang

et al. 2014

Sci Rep

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Uremia results in a relatively immunocompromised status, and patients under chronic dialysis have an elevated risk of developing herpes zoster (HZ). We sought to investigate the relationship between vitamin D status and immunity to varicella-zoster virus (VZV). A multicenter prevalent hemodialysis cohort was assembled between 2012 and 2013. We assayed the biochemical parameters, 25-hydroxy- (25-OH-D) and 1,25-dihydroxyvitamin D, vitamin D-binding protein levels in the sera. VZV immunity was quantitated using VZV-specific glycoprotein IgG and IgM titers. Eighty-eight patients were enrolled and their sera were analyzed. Chronic hemodialysis patients with 25-OH-D < 30 ng/ml (insufficiency or deficiency) had significantly lower VZV-IgG than those with sufficient 25-OH-D (p = 0.04). This discrepancy became more prominent if active vitamin D users alone were analyzed (p = 0.01). Generalized additive modeling showed that those with 25-OH-D higher than 27.8 ng/ml or bioavailable 25-OH-D higher than 3.88 ng/ml had significantly higher VZV-IgG levels than those with lower values. Linear regression suggested that both total and bioavailable 25-OH-D were significantly associated with higher VZV-IgG levels (p = 0.003 [total] and 0.01 [bioavailable]), whereas patients with cancer had lower VZV-IgG. Vitamin D may therefore be a potentially useful choice for raising VZV immunity in chronic dialysis patients.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels are positively associated with varicella zoster immunity in chronic dialysis patients

Chao

Lee

Yang

et al. 2014

Sci Rep

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“…To date, there are 65 publications [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83] on the association of VDR gene SNPs in T1D: these include case-control datasets [20,22,23,25,26,27,28,…”

Section: Vitamin D Pathwaysmentioning

confidence: 99%

“…A total of 39 publications support an association between VDR SNPs rs7975232 ( ApaI ), rs1544410 ( BsmI ), rs731236 ( TaqI ) and rs10735810 ( FokI ) alone or in combination with each other, (rs757343 Tru9I , rs1540339 and rs4760648) and T1D [19,21,22,23,24,26,27,28,29,30,34,35,36,37,38,40,41,42,43,44,46,48,49,50,52,53,55,56,59,60,61,62,63,65,68,69,70,71,73] (Table 2) in comparison with 16 studies that refute it [20,25,31,32,39,45,47,51,54,57,58,64,66,67,72,74]. …”

Section: Vitamin D Pathwaysmentioning

confidence: 99%

“…It found a preferential transmission of the VDR “b” allele of the rs1544410 ( BsmI ) site and haplotypes “bT”, “bAT” to affected offspring [19]. In the same line, Abd-Allah et al (2014) [68] observed in children from Egypt a significantly different rs1544410 ( BsmI ) genotype frequency between T1D and control subjects with the “b” allele the “bb” genotype conferring T1D susceptibility. Moreover, significantly more heterozygote carriers of “Aa” and “Bb” were observed in T1D patients, confirming the risk of the b allele as reported by Bonakdaran et al (2012) [61] in an Iranian population.…”

Section: Vitamin D Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Penna-Martinez

Badenhoop

2017

Genes

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The etiology and pathophysiology of type 1 diabetes remain largely elusive with no established concepts for a causal therapy. Efforts to clarify genetic susceptibility and screening for environmental factors have identified the vitamin D system as a contributory pathway that is potentially correctable. This review aims at compiling all genetic studies addressing the vitamin D system in type 1 diabetes. Herein, association studies with case control cohorts are presented as well as family investigations with transmission tests, meta-analyses and intervention trials. Additionally, rare examples of inborn errors of vitamin D metabolism manifesting with type 1 diabetes and their immune status are discussed. We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Associations, however, are tenuous in relation to the ethnic background of the studied populations. Intervention trials identify the specific requirements of adequate vitamin D doses to achieve vitamin D sufficiency. Preliminary evidence suggests that doses may need to be individualized in order to achieve target effects due to pharmacogenomic variation.

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“…More than 60 polymorphisms in introns or regulatory areas other than exons have been reported in the gene. Three common polymorphisms have been identified -BsmI (rs1544410) and ApaI (rs7975232), both in intron 8; TaqI (rs731236), in exon 9- [14][15][16][17]. These three polymorphisms are located near the 3′end of the VDR gene [18].…”

Section: Introductionmentioning

confidence: 99%