Vitamin D status and the Cdx-2 polymorphism of the vitamin D receptor gene are determining factors of bone mineral density in young healthy postmenopausal women

Casado-Díaz, Antonio; Cuenca-Acevedo, Rafael; Navarro-Valverde, Cristina; Díaz-Molina, Carmen; Caballero-Villarraso, Javier; Santiago-Mora, Raquel; Dorado, Gabriel; Quesada‐Gómez, José Manuel

doi:10.1016/j.jsbmb.2012.09.026

Cited by 20 publications

(11 citation statements)

References 7 publications

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“…At the same time, the presence of the minor genotype TT favoured the lower TS blood level. It represented the biological role of these regulatory factors in the bone tissue mineralization process and agreed with the previously obtained results [9,13]. The highest value of the F-test (F=7,2; p=0,0047) was noted for BMD.…”

Section: Results and Their Discussionsupporting

confidence: 91%

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Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis

Зябліцев¹,

Os²

2015

Fiziol Zh

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Section: Results and Their Discussionsupporting

confidence: 91%

“…Consequently, protein, shorter by three amino acids, is synthesized (the transcription begins with the second site of initiation, which is localized for three codons further) [8,9]. It leads to disturbance of Ca absorption in the small intestine and to hypocalcemia.…”

Section: Introductionmentioning

confidence: 99%

Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis

Зябліцев¹,

Os²

2015

Fiziol Zh

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“…, and competitive protein-binding techniques, in one 41 . In five studies, the laboratory technique employed was not reported [42][43][44][45][46] .…”

Section: Methodsmentioning

confidence: 99%

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Valladares

Simões

Bernardo

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY BACKGROUND: Hypovitaminosis D is considered a global public health issue. Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health. OBJECTIVES: The aim of this study was to evaluate the prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D concentration < 30 ng/ml, in postmenopausal women around the world, as well as to identify the potential associated factors. METHODS: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses recommendations. Specific search terms were consulted in Medline, Excerpta Medica, and Latin-American and Caribbean Health Sciences Literature databases, with no restriction for the year or language of publication. RESULTS: Of 451 studies initially identified, 32 were selected for analysis. Collectively, those 32 studies evaluated 21,236 postmenopausal women, of whom 16,440 (77.4%) had serum 25-hydroxyvitamin D concentrations < 30 ng/ml. The reported prevalence of hypovitaminosis D ranged from 29% (in the United States) to 99.4% (in China). In six of the studies, the prevalence was above 90%. CONCLUSIONS: If the criterion is the 30 ng/ml cut-off point, the majority of postmenopausal women in the world could be classified as having hypovitaminosis D. Among the studies evaluated, the lowest prevalence reported was nearly 30%. Neither latitude, region of the world, nor laboratory methodology were found to be associated with the prevalence of hypovitaminosis D.

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“…Cdx-2 polymorphism is located in the DNA-binding portion of the gene, and therefore likely influences other transcriptional processes; polymorphisms in the VDR gene promoter region are important for the regulation of calcium absorption (Rowland et al, 2012). Casado-Díaz et al (2013) reported that female carriers of the A allele have a lower risk of osteoporosis compared to the carriers of the G allele. The A allele of the Cdx-2 G > A polymorphism (rs11568820) shows higher transcriptional activity, while the Cdx-2 G allele is associated with decreased VDR functional activity (OchsBalcom et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature

Wang¹,

Xp²,

Lx³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Polymorphisms in the vitamin D receptor (VDR) gene are associated with idiopathic short stature (ISS) in several countries. This study aimed to identify a possible correlation between polymorphisms in the VDR promoter in Chinese children with ISS and the efficacy of the recombinant human growth hormone (rhGH) treatment. Pre-pubertal children with ISS and healthy age-and gendermatched children (N = 95 each) were enrolled in this study. Two single nucleotide polymorphisms (SNPs) in the VDR promoter (rs11568820 at the Cdx-2-binding site upstream of exon 1e and rs4516035 at -1012 upstream of exon 1a) were typed. The growth velocity, standard W. Wang et al.

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Vitamin D status and the Cdx-2 polymorphism of the vitamin D receptor gene are determining factors of bone mineral density in young healthy postmenopausal women

Cited by 20 publications

References 7 publications

Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis

Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis

Prevalence of hypovitaminosis D in postmenopausal women: a systematic review

Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature

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