Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus

Gradinaru, Daniela; Borsa, Claudia; Ionescu, Cristina; Margina, Denisa; Prada, Gabriel I.; Jansen, Eugène

doi:10.1007/bf03654842

Cited by 42 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a negative correlation between vitamin D and AOPP levels. Similar results had been reported in previous studies [44,45]. Vitamin D supplementation was accompanied by better glycaemic control and decreased AOPP level as an OS marker [45].…”

Section: Discussionsupporting

confidence: 91%

“…Vitamin D supplementation was accompanied by better glycaemic control and decreased AOPP level as an OS marker [45]. As diabetes progresses and vascular complications such as nephropathy develop, the AOPP level increases and patients with diabetic vascular complications have significantly higher levels of AOPP compared with patients with non‐complicated diabetes [44, 46].…”

Section: Discussionmentioning

confidence: 99%

“…Gradinaru et al. [44] showed increased levels of AGEs in patients with T2D. In normal metabolic milieu, the reaction of reducing sugars with lipids, proteins and DNA molecules produces AGEs as by‐products, but under hyperglycaemia and OS, these reactions and AGE production are accentuated [47].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Hashemi,

Karimpour Reyhan,

Qahremani

et al. 2024

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

AimTo investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.MethodIn this cross‐sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.ResultVitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = −0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = −0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.ConclusionThis research indicates the relationship between vitamin D levels and oxidative stress biomarkers in patients with Type 2 diabetes.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Hashemi,

Karimpour Reyhan,

Qahremani

et al. 2024

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

show abstract

“…Gradinaru et al reported a much lower value of 7.2%, which might be due to inclusion of subjects with only good and moderate glycemic control(<8.5%). [37] Similarly Aoucheri et al, Zare-Mirzaie et al, and Dhas et al, reported relatively lower values. [38,39,40] Sheth et al reported values of 8.36% ± 1.79%, which were comparable to those of the current study.…”

Section: Table;5mentioning

confidence: 89%

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Singh,

Kaur,

Verma

2023

J. Adv. Zool.

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) has a heavy disease burden and is one of the leading causes of death worldwide. It is considered to be evolving from a complex and multifactorial metabolic disorder to an inflammatory condition. The strong link between hyperglycemia and oxidative stress has long been established. Oxidative stress leads to the generation of inflammatory mediators and reactive oxygen species, which results in an inflammatory state, which plays a key role in the pathogenesis of diabetic complications. We aimed to correlate the levels of Glycated Hemoglobin with Oxidative Stress.This cross-sectional study included 200 subjects, 100 were type 2 diabetic patients and 100 were healthy non-diabetic individuals. The data were analyzed using a t test. The results showed that as the Glycated Hb increased, the levels of FBS, MDA increased and Serum SOD, Glutathione and Catalase levels decreased. The results showed a positive correlation between HbA1c and fasting blood glucose (r = 0.417, p= 0.000) and MDA (r= 0.340, p=0.000). Whereas negative correlation was observed between HbA1c and other antioxidant parameters, SOD (r= 0.025, p=0.803) Catalase (r= 0.096, p= 0.342), Glutathione (r= -0.164, p= 0.103). It is hereby concluded for the present study that when glycated Hb increases the natural antioxidants that is SOD, catalase and glutathione decrease to combact the increased formation of ROS. Serum MDA, a marker of lipid peroxidation, increased with increased glycated Hb, and shows a positive correlation, indicating that lipid peroxidation increased, when glycation of Hb increased, thus depicting an increased chance of macrovascular complication in type 2 diabetics.

show abstract

Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis

Shen

Zhuang

2016

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus

Cited by 42 publications

References 30 publications

Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Correlation of Glycated Hemoglobin with Oxidative Stress in Type 2 Diabetes Mellitus

Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis

Contact Info

Product

Resources

About