Vitamin D status and metabolic syndrome in Asian Indians

Majumdar, Vijaya; Nagaraja, D; Christopher, Rita

doi:10.1038/ijo.2010.232

Cited by 50 publications

(50 citation statements)

References 19 publications

(24 reference statements)

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“…However, our results are in agreement with a study that was conducted in Asian --Indian adults, which demonstrated a high prevalence of vitamin D insufficiency (25-OHD level o50 nmol l À1 ), but no association between vitamin D insufficiency and insulin resistance. 33 In contrast to the inverse relationship between plasma iPTH and insulin sensitivity demonstrated in a previous study, 34 our study did not find such a relationship. As the iPTH level has an inverse correlation with the 25-OHD level, the lack of an association between iPTH level and insulin sensitivity in our study may have been indirectly due to the lack of association between 25-OHD level and insulin sensitivity.…”

Section: Discussioncontrasting

confidence: 99%

Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics

et al. 2012

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BACKGROUND: Pediatric obesity continues to rise and has become a major health problem worldwide. Vitamin D deficiency has been increasing among obese non-Asian children and is associated with abnormal glucose homeostasis in obese adults. However, data on the vitamin D status and its association with glucose homeostasis in obese children residing in tropical Asian countries are unavailable. OBJECTIVE: To assess vitamin D status and glucose homeostasis in obese Thai children. PATIENTS AND METHODS: A total of 150 obese, and 29 healthy non-obese children and adolescents were enrolled. Weight, height, body mass index (BMI) and waist circumference were obtained. All obese children underwent an oral glucose tolerance test with glucose and insulin measurements. Plasma 25-hydroxyvitamin D (25-OHD) and calciotropic blood chemistries were measured in all participants. Insulin sensitivity indices were calculated from the measured glucose and insulin levels. RESULTS: Approximately 25% of the obese children and adolescents had impaired glucose tolerance, impaired fasting plasma glucose (FPG) and diabetes. Seventeen out of 150 (11.3%) obese children and 3 out of 29 (10.3%) non-obese children had vitamin D deficiency, which was defined as a 25-OHD level of o50 nmol l À1 . Glucose tolerance and insulin sensitivity indices were comparable between obese children with sufficient vitamin D and those with vitamin D deficiency. There were no relationships among serum 25-OHD; weight, height, and BMI standard deviation scores; insulin sensitivity indices; FPG and insulin; and 2-h plasma glucose and insulin levels. CONCLUSION: Vitamin D deficiency is not as prevalent in obese Thai children as in obese non-Asian children from highlatitude countries. Adiposity per se is unlikely to be a determinant of vitamin D status in these obese individuals. There was no association between vitamin D deficiency and abnormal glucose homeostasis.

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Section: Discussioncontrasting

confidence: 99%

Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics

et al. 2012

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“…Like other studies our data also showed significant gender-specific differences. While some studies [25] show that males are at higher risk of MS as compared to females, our study like other studies in similar settings [24,26], showed higher (2.5 times) prevalence among females. Older subjects had higher odds of developing MS (Age> 46 had 1.9 times higher odds than Age≤46).…”

Section: Discussionsupporting

confidence: 58%

“…Studies have reported a prevalence of 70-100% of vitamin D deficiency in the Indian subcontinent [24,26] which is much higher than the prevalence range reported globally 30-50% [5,7,13]. There is a continued debate in the published literature with respect to the optimum cut-off for 25(OH) D. For the purpose of maintaining uniformity, we used the categories used in studies based in South Asia [17,18,26].…”

Section: Discussionmentioning

confidence: 99%

“…This study aims to add to the sparse evidence in this area [17,18] with the objective to estimate the prevalence of MS as defined by the International Diabetes Federation [19] and to assess the association between vitamin D levels and metabolic syndrome in an Asian Indian population from Hyderabad in south India.…”

Section: Journal Of Nutritional Disorders and Therapymentioning

confidence: 99%

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Prevalence of Vitamin D Deficiency, Metabolic Syndrome and Association Between the Two in a South Asian Population

Allam¹,

Pant²,

Uthappa³

et al. 2018

J Nutr Disorders Ther

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“…Several authors demonstrated indifferent gender results in their studies with MS patients. 37,43 Our results can be explained by traditional clothing style of the women where our study was performed. It was found that in Turkish regions where women wore clothes with covered arms, Vit D levels were lower than the other parts of Turkey.…”

Section: Resultsmentioning

confidence: 82%

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Evrim¹,

Atalay²,

Gürsoy³

et al. 2016

Turkiye Klinikleri J Endocrin

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A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : Hypovitaminosis D and metabolic syndrome are worldwide common problems. The link between them was unresolved. We planned to define the relation between Vitamin D levels and metabolic syndrome and also their parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We evaluated all the demographic and anthropometric parameters of 79 healthy participants and 95 patients with metabolic syndrome and compared those parameters and vitamin D levels. We classified 25(OH)D serum levels; <10ng/mL as serious deficiency, 10-20 ng/mL as deficiency, 20-30 ng/mL insufficiency and > 30 ng/mL as normal status. We searched the correlation of vitamin D levels with metabolic syndrome parameters. We also examined the relation of various Vitamin D levels with demographic and anthropometric findings of metabolic syndrome patients. R Re es su ul lt ts s: : Vitamin D levels were low in all the individuals (12.8 ± 6.7ng/mL in patients and 19.0 ± 10.0ng/mL in controls. p<0.001). In metabolic syndrome patients, serious deficiency was high and normal Vit D status was significantly low especially in females. In metabolic syndrome group vitamin D levels were negatively correlated with body mass index, waist circumference, blood glucose, hemoglobin A1c, fasting insulin, insulin resistance index (p <0.012, <0.040, <0.002, <0.008, <0.006, <0.001 respectively). We found that vitamin D levels of the patients without hypertension, diabetes mellitus, dyslipidemia or obesity were higher than that of the patients with those diseases among metabolic syndrome group (all p<0.001). We also demonstrated as Vitamin D levels decreased, rate of obesity, hypertension and diabetes mellitus increased, (p<.0.029, <0.035 and <0.001 respectively). C Co on nc cl lu us si io on n: : In patients with metabolic syndrome hypovitaminosis D is frequent especially in women. As Vitamin D levels are in negative correlation with obesity, diabetes and insulin resistance indices and also with metabolic syndrome parameters, we concluded that Vitamin D supplementation is important in hypovitaminosis D cases with metabolic syndrome. Ya zış ma Ad re si/Cor res pon den ce:

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Vitamin D status and metabolic syndrome in Asian Indians

Cited by 50 publications

References 19 publications

Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics

Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics

Prevalence of Vitamin D Deficiency, Metabolic Syndrome and Association Between the Two in a South Asian Population

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

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