Vitamin D status and its associations with clinical and laboratory parameters in patients with Addison’s disease

Zawadzka, Karolina; Matwiej, Katarzyna; Sokołowski, Grzegorz; Trofimiuk–Müldner, Małgorzata; Skalniak, Anna; Hubalewska‐Dydejczyk, Alicja

doi:10.1530/endoabs.70.aep1023

Cited by 3 publications

(6 citation statements)

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“…A total of 90.3% of AD patients had inadequate vitamin D concentrations (<30 ng/ml), and 19.3% of them were found to be severely vitamin D deficient (<10 ng/ml). They also found only serum calcium concentrations significantly correlated with VD status (r=0.53, p=0.006) 17 . This and similar studies have shown that vitamin D could play a protective role in the pathogenesis of AD 5 .…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

“…This can be explained by the fact that AD only exists in patients with APS-2 who use long-term high-dose glucocorticoids. Only a few observational studies investigated the link between vitamin D plasma levels and AD [17]. A record-linkage study by Ramagopalan et al showed that a large cohort of patients admitted to a UK hospital for vitamin D deficiency significantly elevated rates of AD (rate ratio = 7.0 % CI: 3.6-12.3) and other autoimmune diseases [8].…”

Section: Discussionmentioning

confidence: 99%

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Bone Mineral Density and Vitamin D Status in Patients with Autoimmune Polyglandular Syndromes: A Single Tertiary Care Center Experience

Akkurt Kocaeli,

Erturk

2023

Horm Metab Res

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Immunological abnormalities, the resulting endocrinopathies, and their treatments may impact bone health and 25-hydroxyvitamin D (25-OHD) in patients with autoimmune polyglandular syndromes (APS). Several etiologies contribute to increased risk for low bone mineral density (BMD), including vitamin D deficiency. This study evaluated the vitamin D level and BMD of patients with APS. We performed a cross-sectional study on 44 patients with APS and 55 age and gender-matched control subjects. Among patients with APS, 14 were classified as APS-2 [Addison’s disease (AD)+autoimmune thyroid disease (ATD) and/or type 1 diabetes(T1D)]. In contrast, the other 30 were APS-3 (ATD+T1D+other autoimmune diseases). Serum samples were analyzed for vitamin D levels. The lumbar spine and femoral neck BMD were measured by dual X-ray absorptiometry. Z-scores were obtained by comparison with age- and gender-matched average values (both patients and controls). The accepted normal levels were Z-score>–1 and 25-OHD>30 ng/ml. Patients with APS showed 25-OHD levels and BMD significantly lower than healthy controls (p<0.001 and p<0.05, respectively). The highest prevalence of abnormal BMD was observed in the APS-2 subgroup (13 out of 14 patients, 92.6%). Identifying and treating vitamin D deficiency and low BMD is critical in APS patients. The fact that the significant endocrine component of APS-2 is AD, and these patients receive chronic long-term glucocorticoid therapy can be shown as the reason for this result. However, more extensive prospective controlled studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bone Mineral Density and Vitamin D Status in Patients with Autoimmune Polyglandular Syndromes: A Single Tertiary Care Center Experience

Akkurt Kocaeli,

Erturk

2023

Horm Metab Res

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“…In fact, an alteration of serotonin resulted in an alteration of fatigue [48]. This connection was also underlined by Zawadzka et al (2021), who emphasized how fatigue is linked to an altered central relationship between serotonin and dopamine [49].…”

Section: Vitamin D's Interaction With Neurotransmittersmentioning

confidence: 94%

Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review

Di Molfetta,

Bordoni,

Gabbianelli

et al. 2024

Nutrients

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Vitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, diabetes, or a condition of fatigue). This narrative review investigates the current knowledge of the pathophysiological mechanisms underlying fatigue and the ways in which vitamin D is implicated in these processes. Scientific studies in the databases of PubMed, Scopus, and Web of Science were reviewed with a focus on factors that play a role in the genesis of fatigue, where the influence of vitamin D has been clearly demonstrated. The pathogenic factors of fatigue influenced by vitamin D are related to biochemical factors connected to oxidative stress and inflammatory cytokines. A role in the control of the neurotransmitters dopamine and serotonin has also been demonstrated: an imbalance in the relationship between these two neurotransmitters is linked to the genesis of fatigue. Furthermore, vitamin D is implicated in the control of voltage-gated calcium and chloride channels. Although it has been demonstrated that hypovitaminosis D is associated with numerous pathological conditions, current data on the outcomes of correcting hypovitaminosis D are conflicting. This suggests that, despite the significant involvement of vitamin D in regulating mechanisms governing fatigue, other factors could also play a role.

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“…Another recent study by Zawadzka et al. ( 70 ) retrospectively analyzed medical records of 31 adult patients with the diagnosis of autoimmune AD and demonstrate a high incidence of vitamin D deficiency and a significant correlation between low levels of vitamin D and severe fatigue as well as limited exercise capacity in AD patients.…”

Section: Vitamin D and Primary Adrenal Insufficiencymentioning

confidence: 99%

Vitamin D and adrenal gland: Myth or reality? A systematic review

et al. 2022

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In recent years, vitamin D has become the protagonist in many studies. From cardiology to oncology the spotlight was on this vitamin. While in the past it was considered for its important role in phospho-calcium metabolism and skeletal disorders; today by studying it better, thousands of scenarios and facets have opened up on this vitamin which is actually a hormone in all respects. There are authoritative studies that demonstrate its activity in vitro and in vivo on: carcinogenesis, inflammation, autoimmunity and endocrinopathies. Its role has been studied in type 1 and type 2 diabetes mellitus, in Hashimoto or Graves’ thyroiditis and even in adrenal gland diseases. In fact, there are several studies that demonstrate the possible correlations between vitamin D and: Addison’s disease, Cushing disease, hyperaldosteronism or adrenocortical tumors. Moreover, this fascinating hormone and adrenal gland even seem to be deeply connected by common genetic pathways. This review aimed to analyze the works that have tried to study the possible influence of vitamin D on adrenal diseases. In this review we analyze the works that have tried to study the possible influence of vita-min D on adrenal disease.

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Vitamin D status and its associations with clinical and laboratory parameters in patients with Addison’s disease

Cited by 3 publications

References 0 publications

Bone Mineral Density and Vitamin D Status in Patients with Autoimmune Polyglandular Syndromes: A Single Tertiary Care Center Experience

Bone Mineral Density and Vitamin D Status in Patients with Autoimmune Polyglandular Syndromes: A Single Tertiary Care Center Experience

Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review

Vitamin D and adrenal gland: Myth or reality? A systematic review

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