Vitamin D status and functional parameters: A cross-sectional study in an older population

Mendes, Joana; Santos, Alejandro; Borges, Nuno; Afonso, Cláudia; Moreira, Pedro; Padrão, Patrícia; Negrão, Rita; Amaral, Teresa

doi:10.1371/journal.pone.0201840

Cited by 21 publications

(19 citation statements)

References 66 publications

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“…Previous studies have revealed controversial results regarding the relationship between vitamin D and hand grip strength [4,47,48]. Our results could contribute to clarify the association between vitamin D and hand grip strength, providing more complete information about bone metabolism biomarkers in an older population which was not considered in other studies [4,42,43,44]. In addition, our results were adjusted for a set of covariables, such as age and gender.…”

Section: Discussionmentioning

confidence: 88%

“…In addition, more extraskeletal effects of vitamin D have been revealed, and the diverse functions of vitamin D have also been supported by the discovery that vitamin D receptors (VDRs) and vitamin D activating enzymes (hydroxylases) are present in the tissues and cells not involved in mineral and bone metabolism. Because VDRs have been located in multiple tissues, vitamin D deficiency has been associated with an increased risk of chronic diseases such as cardiovascular disease, diabetes, and dementia [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

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Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

et al. 2019

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As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum levels of total calcium, phosphorus, intact parathyroid hormone, albumin, and 25-hydroxyvitaminD3 were analyzed. We also recruited data for QoL, physical activity, nutritional impairment, and muscular strength. Ninety percent of the subjects were classified as vitamin D deficient or insufficient. Participants with higher serum 25(OH)D3, calcium, phosphorous, and Alb levels were significantly less likely to self-report depression or anxiety after adjustment (p = 0.009, p = 0.005, p = 0.003, and p = 0.005, respectively). Additionally, we found an association between lower levels of albumin and self-reported problems with mobility or usual activities (p = 0.01). We also found associations between better muscle strength and higher levels of vitamin D, calcium, phosphorous, and albumin (p = 0.006, p = 0.003, p = 0.004 and p = 0.002, respectively). Overall, our data provide evidence that serum vitamin D and Alb levels are negatively related to self-reported anxiety or depression, usual activities, mobility, and three dimensions of QoL in older adults. Furthermore, vitamin D levels are positively related to hand grip strength in adults over 65 years old.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

et al. 2019

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“…Finally, we did not consider the impact of vitamin D on the quality of life, functional status and neither on the metabolic parameters, that have been previously related with vitamin D levels and with long-term outcomes [45,46] In fact, in our study patients with lower vitamin D displayed higher glycemia and cholesterol levels, even despite a larger use of statins.…”

Section: Limitationsmentioning

confidence: 79%

Prognostic impact of Vitamin D deficiency in patients with coronary artery disease undergoing percutaneous coronary intervention

Verdoia

Nardin²,

Rolla³

et al. 2021

European Journal of Internal Medicine

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Background: Whether Vitamin D deficiency represents an independent predictor of mortality and major cardiovascular events or rather the mirror of a more advanced clinical condition with increased comorbidities is still debated. We aimed at assessing the impact of vitamin D levels on the long-term outcomes among patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention. Methods: Consecutive patients from a single centre were included. Vitamin D levels were measured at admission by chemiluminescence immunoassay kit LIAISON® Vitamin D assay (Diasorin Inc). Severe deficiency was defined for 25(OH)D < 10 ng/ml. The primary study endpoint was overall mortality. Secondary endpoints were cardiovascular mortality, recurrent acute coronary syndrome or major cardiovascular events (a composite of death, recurrent MI and target vessel revascularization) at the longest available follow-up. Results: We included a total of 705 patients, that were divided according to vitamin D tertiles (<12.7; 12.7-21.59; ≥21.6 ng/ml). Lower levels of Vitamin D were associated with renal failure (p=0.03), more severe coronary disease (p=0.001), diabetes mellitus and previous CABG (p<0.001), lower ejection fraction (p=0.02), acute presentation (p=0.04), use of statins (p=0.02), diuretics, nitrates and clopidogrel (p<0.001) and RASI (p=0.008). An inverse association was documented with BMI, glycemia, total cholesterol (p<0.001), creatinine and WBC (p=0.001). At a median follow-up of 996.5 [377-1552] days, 3.8% of the patients died. Vitamin D deficiency was significantly associated with overall mortality (7.6% vs 2.9% vs 0.4%, adjusted HR[95%CI] =3.6[1.43-8.9], p=0.006), MACE (adjusted HR[95%CI]=1.32[1.07-1.63], p=0.01) and the composite of death and MI (adjusted HR[95%CI]=1.3[1.03-1.65], p=0.03). A similarly increased risk was confirmed for all major higher-risk subsets of patients, with no significant interaction according to age, gender, diabetes mellitus or chronic kidney disease. Conclusion: Among patients undergoing percutaneous coronary interventions, lower levels of vitamin D are associated with an over 3-fold increased risk of mortality and major cardiovascular events. Future larger studies are certainly warranted in order to define the prognostic implications of cholecalciferol supplementation among high-risk patients with established coronary artery disease.

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“…In 2018, Mendes et al evaluated 1,425 older people individuals (mean age: 75.4 ± 7.5 years in women and 74.2 ± 6.7 years in men) and found a signi cant association between vitamin D de ciency and decreased gait speed and HGS, especially in men (41.5% of the total sample) [22]. Of the participants of our study, only 28% were men, with a much smaller age group (67.18 ± 5.33 years), which could explain, at least in part, the con icting results.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Hypovitaminosis D Status with Muscle Strength and Functional Capacity in a Brazilian Community-Dwelling Elderly Population: A Cross- Sectional Study

Pelizari¹,

Pereira²,

Pereira³

et al. 2021

Preprint

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Background: Although there have been studies on the association between hypovitaminosis D status with muscle strength and functional capacity, there were few studies on Brazilian community-dwelling elderly population. Therefore, this study aims to assess the association of hypovitaminosis D with muscle strength and functional capacity in a sample Brazilian community-dwelling elderly population.Methods: An analytical, cross-sectional observational study with a convenience sample was conducted. The 25(OH)D levels were assessed using an enzyme-linked fluorescent assay and classified according to the standardization of the Brazilian Society of Clinical Pathology/Laboratory Medicine. Hand grip strength (HGS) and isometric quadriceps strength (IQS) were measured using manual Jamar® and Lafayette® 01165 dynamometers, respectively. Functional capacity was evaluated using the Short Physical Performance Battery (SPPB). Multiple linear regression models were used to assess the association of hypovitaminosis D with the HGS, IQS, and SPPB score via the Enter method. The models were adjusted for age, sex, presence of pain, level of physical activity, and use of vitamin D supplementation. Results: A total of 150 elderly individuals (age: 67.18±5.33 years) were included. According to the 25(OH)D levels, 60.7% had hypovitaminosis D (insufficient: 48%, deficient: 12.7%), and 39.3% had sufficient levels. No associations were found between hypovitaminosis D and the HGS (p=0.84), LogIQS (p=0.462), and SPPB score (p=0.617). In the regression model, the influence of the vitamin D levels on functional capacity was not significant, demonstrating no association between them.Conclusion: Hypovitaminosis D was not associated with decreased muscle strength and functional capacity in the sample Brazilian community-dwelling elderly population. Longitudinal studies with measurement of the time of use and levels of vitamin D are encouraged.

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Vitamin D status and functional parameters: A cross-sectional study in an older population

Cited by 21 publications

References 66 publications

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Prognostic impact of Vitamin D deficiency in patients with coronary artery disease undergoing percutaneous coronary intervention

The Association Between Hypovitaminosis D Status with Muscle Strength and Functional Capacity in a Brazilian Community-Dwelling Elderly Population: A Cross- Sectional Study

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