Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population

Reis, Jared P.; Mühlen, Denise von; Miller, Edgar R.; Michos, Erin D.; Appel, Lawrence J.

doi:10.1542/peds.2009-0213

Cited by 317 publications

(302 citation statements)

References 52 publications

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“…A significant association between 25(OH)D and CVD risk factors in children and adolescents would suggest that successful vitamin D supplementation has the potential to improve CVD risk markers and to lower the risk of CVD in adulthood. However, compared with adults, the associations between vitamin D and MetS as well as its individual CVD risk factors have not been fully explored in children (18)(19)(20)(21)(22)(23)(24)(25)(26)(27). We therefore conducted a crosssectional study to examine the association of serum vitamin D levels with the MetS, its individual components, and early atherosclerotic abnormalities in a large sample of Italian overweight/obese and normalweight children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Pacifico

Anania

Osborn

et al. 2011

European Journal of Endocrinology

161

122

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Objectives: Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D 3 (25(OH)D 3 ) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese and 148 healthy, normal weight) Caucasian children. Methods: We determined serum 25(OH)D 3 concentrations in relation to MetS, its components (central obesity, hypertension, low high-density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, glucose impairment, and/or insulin resistance (IR)), and impairment of flow-mediated vasodilatation (FMD) and increased carotid intima-media thickness (cIMT) -two markers of subclinical atherosclerosis. Results: Higher 25(OH)D 3 was significantly associated with a reduced presence of MetS. Obesity, central obesity, hypertension, hypertriglyceridemia, low HDL-cholesterol, IR, and MetS were all associated with increased odds of having low 25(OH)D 3 levels, after adjustment for age, sex, and Tanner stage. After additional adjustment for SDS-body mass index, elevated blood pressure (BP) and MetS remained significantly associated with low vitamin D status. The adjusted odds ratio (95% confidence interval) for those in the lowest (!17 ng/ml) compared with the highest tertile (O27 ng/ml) of 25(OH)D 3 for hypertension was 1.72 (1.02-2.92), and for MetS, it was 2.30 (1.20-4.40). A similar pattern of association between 25(OH)D 3 , high BP, and MetS was observed when models were adjusted for waist circumference. No correlation was found between 25(OH)D 3 concentrations and either FMD or cIMT. Conclusions: Low 25(OH)D 3 levels in Caucasian children are inversely related to total adiposity, MetS, and hypertension.

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Section: Introductionmentioning

confidence: 99%

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Pacifico

Anania

Osborn

et al. 2011

European Journal of Endocrinology

161

122

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“…43 Data from the National Health and Nutrition Examination Survey (NHANES) 2001-2004 concluded that low 25(OH)D levels were associated with hyper-tension, hyperglycemia, and metabolic syndrome in the United States adolescent population. 44 Similarly, a study in Caucasian children also found that central obesity, hypertension, hypertriglyceridemia, low HDL-C levels, and metabolic syndrome were associated with low 25(OH)D levels. 45 Despite the fact that in our study vitamin D was assessed only by nutritional intake, our results are in line with those of these investigations by showing that adolescents in the lowest vitamin D intake quartile group had an OR of 3.35 for high cardiometabolic risk score compared with the highest vitamin D intake quartile group after adjustment for several confounders.…”

Section: Discussionmentioning

confidence: 93%

Vitamin D Intake and Cardiometabolic Risk Factors in Adolescents

Moreira

Abreu

et al. 2014

Metabolic Syndrome and Related Disorders

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Background: A growing body of research suggests that vitamin D might play an important role in overall health. No data exist on vitamin D intake for the Azorean adolescent population. The purpose of this study was to assess vitamin D intake and investigate a possible association between vitamin D intake and cardiometabolic risk factors in Azorean adolescents. Methods: A cross-sectional school-based study was conducted on 496 adolescents (288 girls) aged 15-18 years from the Azorean Islands, Portugal. Anthropometric measurements (waist circumference and height), blood pressure (systolic), and plasma biomarkers [fasting glucose, insulin, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs)] were measured to assess metabolic risk. Homeostasis model assessment (HOMA), TC-to-HDL-C ratio, and waist-to-height ratio were calculated. For each of these variables, a Z-score was computed by age and sex. A metabolic risk score was constructed by summing the Zscores of all individual risk factors. High risk was considered when the individual had ‡ 1 standard deviation (SD) of this score. Vitamin D intake was assessed with a semiquantitative food frequency questionnaire. Participants were classified into quartiles of vitamin D intake. Logistic regression was used to determine odds ratios for high cardiometabolic risk scores after adjusting for total energy intake, pubertal stage, fat mass percentage, and cardiorespiratory fitness. Results: Mean (SD) vitamin D intake was 5.8 (6.5) mg/day, and 9.1% of Azorean adolescents achieved the estimated average requirement of vitamin D (10 mg/day or 400 IU). Logistic regression showed that the odds ratio for a high cardiometabolic risk score was 3.35 [95% confidence interval (CI) 1.28-8.75] for adolescents in the lowest vitamin D intake quartile in comparison with those in the highest vitamin D intake quartile, even after adjustment for confounders. Conclusion: A lower level of vitamin D intake was associated with worse metabolic profile among Azorean adolescents.

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“…Em adolescentes obesos, baixas concentrações de vitamina D também têm sido associadas com níveis reduzidos de HDL-c [43] e elevados de triglicerídeos e do índice homeostatic model assessment para resistência à insulina (HOMA-IR) [44]. Um estudo realizado com 3.577 adolescentes americanos com idades entre 12 e 19 anos encontrou maior chance de hipertensão arterial e SM para os indivíduos no menor quartil do nível sérico de 25 (OH) D, em comparação com o maior quartil, independentemente da adiposidade corporal [45].…”

Section: Discussionunclassified

Consumo alimentar e síndrome metabólica em adolescentes

Assis

Novaes

Cândido

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR Consumo alimentar e síndrome metabólica em adolescentes ABSTRACT Aims:To determine the prevalence of metabolic syndrome in adolescents and to compare the dietary intake of individuals with and without the syndrome. Methods: A cross-sectional study was conducted with adolescents aged 15 to 17 years, enrolled in public and private schools in Juiz de Fora, Minas Gerais, Brazil. Body mass index was used to determine the nutritional status, classified according to the World Health Organization. Waist circumference was measured according to Petroski (2003). Triglyceride, high-density lipoprotein cholesterol, fasting blood glucose, and blood pressure were assessed and the International Diabetes Federation criteria were used for the diagnosis of metabolic syndrome. A non-consecutive 3-day food record was used for dietary assessment. The chi-square test, Fisher's exact test, Student's parametric t test or the Mann-Whitney U test were used for associations between the groups. Results: A total of 302 adolescents -51.99% males and 73.51% from public schools -were evaluated. The prevalence of obesity was 27.48% and that of metabolic syndrome was 3.97%; 4.83% among girls and 3.18% among boys (p=0.46). The prevalence of metabolic syndrome among public school students was 4.50% compared with 2.50% (p=0.73) among those from private schools. In the comparison between the groups with and without metabolic syndrome, there were no statistically significant differences in dietary energy and micronutrient adequacy, except for vitamin D (p=0.01). Adolescents with metabolic syndrome consumed less vitamin D than those without the syndrome. Conclusions:The prevalence of metabolic syndrome was found to be relevant considering its complexity, severity, and the age group studied. Lower vitamin D intake was observed among adolescents with metabolic syndrome.

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Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population

Cited by 317 publications

References 52 publications

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Vitamin D Intake and Cardiometabolic Risk Factors in Adolescents

Consumo alimentar e síndrome metabólica em adolescentes

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