Vitamin D status among patients with fractured neck of femur in Hong Kong

Pun, Kong-Pang; Wong, F. H. W.; Wang, C.; Lau, Patrick; Ho, P.W.M.; Pun, W. K.; Chow, Sherman S. M.; Cheng, C.L.; Leong, J. C. Y.; Young, R. T. T.

doi:10.1016/8756-3282(90)90092-d

Cited by 37 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven studies were identified as lower quality studies with a rating of either 1 [34,40] or 2 [38,41,42,46,48]. Comparing these studies with the higher quality studies with ratings 3 [37,43,47,50], 4 [35,36,39,45], or 5 [44,49], there were no signs of heterogeneity (χ 2 1 = 0.14, p = 0.71).…”

Section: Resultsmentioning

confidence: 99%

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

et al. 2010

View full text Add to dashboard Cite

BackgroundVitamin D supplementation for fracture prevention is widespread despite conflicting interpretation of relevant randomised controlled trial (RCT) evidence. This study summarises quantitatively the current evidence from RCTs and observational studies regarding vitamin D, parathyroid hormone (PTH) and hip fracture risk.MethodsWe undertook separate meta-analyses of RCTs examining vitamin D supplementation and hip fracture, and observational studies of serum vitamin D status (25-hydroxyvitamin D (25(OH)D) level), PTH and hip fracture. Results from RCTs were combined using the reported hazard ratios/relative risks (RR). Results from case-control studies were combined using the ratio of 25(OH)D and PTH measurements of hip fracture cases compared with controls. Original published studies of vitamin D, PTH and hip fracture were identified through PubMed and Web of Science databases, searches of reference lists and forward citations of key papers.ResultsThe seven eligible RCTs identified showed no significant difference in hip fracture risk in those randomised to cholecalciferol or ergocalciferol supplementation versus placebo/control (RR = 1.13[95%CI 0.98-1.29]; 801 cases), with no significant difference between trials of <800 IU/day and ≥800 IU/day. The 17 identified case-control studies found 33% lower serum 25(OH)D levels in cases compared to controls, based on 1903 cases. This difference was significantly greater in studies with population-based compared to hospital-based controls (χ21 (heterogeneity) = 51.02, p < 0.001) and significant heterogeneity was present overall (χ216 (heterogeneity) = 137.9, p < 0.001). Serum PTH levels in hip fracture cases did not differ significantly from controls, based on ten case-control studies with 905 cases (χ29 (heterogeneity) = 149.68, p < 0.001).ConclusionsNeither higher nor lower dose vitamin D supplementation prevented hip fracture. Randomised and observational data on vitamin D and hip fracture appear to differ. The reason for this is unclear; one possible explanation is uncontrolled confounding in observational studies. Post-fracture PTH levels are unrelated to hip fracture risk.

show abstract

Section: Resultsmentioning

confidence: 99%

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The relatively lower serum 25(OH)D level among Malays can be explained by their skin pigmentation, lower outdoor activity levels, or greater fat mass. In Hong Kong, the mean serum 25(OH)D was 71 ± 27 nmol/L in adults over 50 years of age [45], but hypovitaminosis D was common among elderly patients with fracture neck of femur [46]. In bottle-fed infants of Hong Kong (on vitamin D fortified milk), serum 25(OH)D levels were normal at 18 months [47].…”

Section: Asiamentioning

confidence: 99%

“…This global report shows that in many studies of elderly population, hospitalised, institutionalised (nursing home or residential care), housebound, and those with greater disabilities have low or lower vitamin D levels compared to healthy adults as they have limited time spent outdoors [44,46,55,58,63,124,132,138,153]. Urbanisation is also a predictor of low levels of vitamin D in Asia and the Middle East, as both men and women dwell and work most often indoors compared to rural communities [24,28,99].…”

Section: Living Condition and Outdoor Activitymentioning

confidence: 99%

Global vitamin D status and determinants of hypovitaminosis D

Wahl²,

et al. 2009

View full text Add to dashboard Cite

“…[15][16][17][18][19][20] A study from Hong Kong showed that hypovitaminosis D was common among elderly patients with femoral neck fractures. 21 A similar study on Japanese postmenopausal women living in Hawaii did not find any significant association between 25(OH)D and either vertebral or nonvertebral fractures. 22 In our study, 88.2% of the population had 25(OH)D levels less than 30 ng/mL.…”

Section: Figure 1 Scatter Plot Of Ipth Versus 25(oh)d Among All Patimentioning

confidence: 83%

Vitamin D Levels, Physical and Biochemical Characteristicsof South East Asian Patients with Osteoporotic Hip Fractures

Chandran

Howe

Goh

et al. 2012

JAFES

View full text Add to dashboard Cite

Objective. Limited information exists on the physical characteristics, bone mineral density (BMD), 25-hydroxyvitamin D [25(OH)D] levels and other biochemical parameters in patients with hip fractures in Asia. We aimed to explore whether these parameters differ between trochanteric and femoral neck (cervical) hip fractures in Singaporean patients.Methodology. 275 patients with osteoporotic hip fractures were evaluated. Multivariate regression models were used to investigate the relationship between physical characteristics, biochemical parameters, renal function, BMD and type of hip fracture.Results. The mean 25(OH)D level noted was 20.4 (8.1) ng/mL. Fifty percent of patients had levels less than 20 ng/mL. Patients with trochanteric fractures were heavier than those with cervical fractures (p=0.021). Logistic regression analysis showed that males were more likely to have trochanteric fractures (OR=1.79, 95% CI 1.03-3.11), and females with trochanteric fractures were older than those with cervical fractures (OR=0.97, 95% CI 0.94-1.00).Conclusion. Vitamin D deficiency was prevalent in half of our population of hip fracture patients. Trochanteric fractures were more common than cervical fractures in men and in older women. In contrast to findings noted in Caucasian populations, neither BMD nor other bone metabolic parameters examined were associated with the preferential occurrence of one type of osteoporotic hip fracture over the other.

show abstract

Vitamin D status among patients with fractured neck of femur in Hong Kong

Cited by 37 publications

References 15 publications

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

Global vitamin D status and determinants of hypovitaminosis D

Vitamin D Levels, Physical and Biochemical Characteristicsof South East Asian Patients with Osteoporotic Hip Fractures

Contact Info

Product

Resources

About