2001
DOI: 10.1093/ajcn/74.2.206
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Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density

Abstract: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.

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Cited by 294 publications
(230 citation statements)
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“…(46) One possible explanation would be that this adaptive mechanism, because it depends on 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 The proposed threshold of 40 nmol/L for serum 25(OH)D levels to enable optimal lumbar spine mineralization during late puberty, even in low-calcium, low-dairy-product conditions, is similar to thresholds proposed earlier for optimal bone mass accrual during growth: 25 TO 30 nmol/L (9,10,13,35,36) or 40 to 50 nmol/L. (10,11) Given the small size of the subgroup with low calcium and low 25(OH)D levels, it was not possible to single out the negative impact of low 25(OH)D levels from that of other factors associated with winter-spring (eg, lower ultraviolet light energy, qualitative difference in sport activities, or diet). But low serum levels of 25(OH)D remain a good marker of the negative impact of these factors on the lumbar spine mineralization of adolescent girls with low calcium intake.…”
Section: Discussionsupporting
confidence: 59%
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“…(46) One possible explanation would be that this adaptive mechanism, because it depends on 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 The proposed threshold of 40 nmol/L for serum 25(OH)D levels to enable optimal lumbar spine mineralization during late puberty, even in low-calcium, low-dairy-product conditions, is similar to thresholds proposed earlier for optimal bone mass accrual during growth: 25 TO 30 nmol/L (9,10,13,35,36) or 40 to 50 nmol/L. (10,11) Given the small size of the subgroup with low calcium and low 25(OH)D levels, it was not possible to single out the negative impact of low 25(OH)D levels from that of other factors associated with winter-spring (eg, lower ultraviolet light energy, qualitative difference in sport activities, or diet). But low serum levels of 25(OH)D remain a good marker of the negative impact of these factors on the lumbar spine mineralization of adolescent girls with low calcium intake.…”
Section: Discussionsupporting
confidence: 59%
“…(9)(10) But the consequences of low 25(OH)D levels are less clear on trabecular bone sites, such as hip, upper femur, and lumbar spine. (8,9,12,13) At the lumbar spine, one longitudinal observational study (13) and two randomized, placebo-controlled studies (42,43) suggest that low 25(OH)D levels may impair bone mass acquisition during the early phase of puberty, but not in girls with more advanced sexual maturation.…”
Section: Discussionmentioning
confidence: 99%
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