Vitamin D: Role in chronic and acute diseases

Álvarez‐Mercado, Ana I.; Mesa, María Dolores; Gil, Ángel

doi:10.1016/b978-0-12-821848-8.00101-3

Cited by 15 publications

(18 citation statements)

References 21 publications

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“…Vitamin D, also called the “sunshine vitamin,” is best known for its role in calcium and skeletal health. Lately, however, vitamin D deficiency has also been strongly associated with extra-skeletal disorders, though the efficacy of vitamin D status correction given are still being debated given the variance in its protein receptors [ 21 , 22 ]. Several meta-analyses and systematic reviews suggest an association between vitamin D deficiency and chronic diseases such as obesity [ 23 ], metabolic syndrome [ 24 ], type 2 diabetes [ 25 ], and rheumatoid arthritis [ 26 ], inflammatory conditions which may progress to ASCVD events.…”

Section: Introductionmentioning

confidence: 99%

Improved HDL Cholesterol through Vitamin D Status Correction Substantially Lowers 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Vitamin D-Deficient Arab Adults

et al. 2023

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This interventional study aimed to determine whether correcting vitamin D status in deficient Arab adults [25(OH)D <50 nmol/L] improves their 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) risk scores. Saudi adults (58 males 62 females) with baseline vitamin D deficiency (<50 nmol/L) were given 50,000 IU cholecalciferol weekly for 2 months, then twice a month, followed by daily 1000 IU until month 6. Fasting blood samples were collected pre- and post-intervention and assessed for glucose, lipids, and 25(OH)D levels. The predicted 10-year ASCVD risk scores were calculated at baseline and after intervention. At baseline, significantly higher 10-year ASCDV risk scores were observed in males than females (9% vs. 3%, p < 0.001). After 6 months, only 21% (25 out of 120) achieved 25(OH)D levels above optimal level (≥75 nmol/L). While modest improvements were seen in glucose and lipid profiles, only HDL cholesterol showed favorable significant changes in all participants, which translated to significantly improved 10-year ASCVD risk scores independent of whether they achieved optimum vitamin D status. Still, those who achieved optimal vitamin D levels had a modestly larger decrease in ASCVD risk scores than those with less optimal 25(OH)D levels (−23% versus −18%) and this improvement was slightly more pronounced in males (−26% versus −10%, or 16% improvement) than females (−47% versus −32%, or 15% improvement). In conclusion, vitamin D status correction significantly enhances HDL cholesterol which prospectively reduces 10-year ASCVD risk as vitamin D levels approach optimum status among adult Arabs with baseline vitamin D deficiency. This improvement appears to be slightly more apparent in males than females.

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Section: Introductionmentioning

confidence: 99%

Improved HDL Cholesterol through Vitamin D Status Correction Substantially Lowers 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Vitamin D-Deficient Arab Adults

et al. 2023

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“…Among the drugs whose effect is pathogenetically justified for the above pathologies, vitamin D preparations are distinguished. Among other effects, vitamin D is known to have a rather powerful antiinflammatory effect, so vitamin D preparations are prescribed as an adjunctive therapy for many acute and chronic diseases [24]. Almost every modern guideline in various nosologies contains such a recommendation.…”

Section: клінічна та експериментальна медицина / Clinical and Experim...mentioning

confidence: 99%

“…Reference values used in Cinevo laboratories (Odesa, Ukraine): adults -30.0-50.0 ng/ ml, but according to known literature sources, the norm of vitamin D in the blood is from 30 to 100 ng/ml; risk of deficiency: <20.0 ng/ml; risk of insufficient intake: <30.0 ng/ml [21,22,24,31].…”

Section: клінічна та експериментальна медицина / Clinical and Experim...mentioning

confidence: 99%

“…Серед препаратів, дія яких є патогенетично обґрунтованою для вищезгаданих патологій, відокремлюються препарати з вітаміном Д. Серед інших впливів, відомо, що вітамін Д володіє доволі потужною протизапальною дією, тому препарати вітаміну Д призначаються у якості додаткової терапії багатьох гострих і хронічних захворювань [24]. Практично кожен сучасний гайдлайн у різних нозологіях містить таку рекомендацію.…”

Section: клінічна та експериментальна медицина / Clinical and Experim...unclassified

“…Референтні значення, прийняті в лабораторіях «Сінево» (м. Одеса, Україна): дорослі: 30,0-50,0 нг/ мл, але згідно відомих літературних джерел норма вмісту вітаміну D у крові складає від 30 до 100 нг/мл; ризик дефіциту: <20,0 нг/мл; ризик недостатнього споживання: <30,0 нг/мл [21,22,24,31].…”

Section: мета дослідженняunclassified

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Influence of Vitamin D on the State of Carbohydrate Metabolism in Covid-19 Reconvalents With First Diagnosed Type 2 Diabetes

Romeyko,

Gushcha,

Volyanska

et al. 2023

VPBM

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Skin pigmentation related variants in Mexican population and interaction effects on serum 25(OH)D concentration and vitamin D deficiency

Rivera-Paredez,

Hidalgo-Bravo,

López-Montoya

et al. 2024

Sci Rep

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Skin pigmentation is negatively associated with circulating vitamin D (VD) concentration. Therefore, genetic factors involved in skin pigmentation could influence the risk of vitamin D deficiency (VDD). We evaluated the impact genetic variants related to skin pigmentation on VD in Mexican population. This cross-sectional analysis included 848 individuals from the Health Worker Cohort Study (ratio males to females ~ 1:3). Eight genetic variants: rs16891982 (SLC45A2), rs12203592 ( IRF4 ), rs1042602 and rs1126809 ( TYR), rs1800404 ( OCA2 ), rs12913832 (HERC2), rs1426654 (SLC24A5), and rs2240751 ( MFSD12) ; involved in skin pigmentation were genotyped. Skin pigmentation was assessed by self-report. Linear and logistic regression were used to assess the association between the variants of interest and VD and VDD, as appropriate. In our study, eight genetic variants were associated with skin pigmentation. A genetic risk score built with the variants rs1426654 and rs224075 was associated with lower VD levels (β = − 1.38, 95% CI − 2.59, − 0.17, p = 0.025). Nevertheless, when examining gene–gene interactions, we observed that rs2240751 × rs12203592 were associated with VD levels (P interaction = 0.021). Whereas rs2240751 × rs12913832 (P interaction = 0.0001) were associated with VDD. Our results suggest that skin pigmentation-related gene variants are associated with lower VD levels in Mexican population. These results underscore the importance of considering genetic interactions when assessing the impact of genetic polymorphisms on VD levels.

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Vitamin D: Role in chronic and acute diseases

Cited by 15 publications

References 21 publications

Improved HDL Cholesterol through Vitamin D Status Correction Substantially Lowers 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Vitamin D-Deficient Arab Adults

Improved HDL Cholesterol through Vitamin D Status Correction Substantially Lowers 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Vitamin D-Deficient Arab Adults

Influence of Vitamin D on the State of Carbohydrate Metabolism in Covid-19 Reconvalents With First Diagnosed Type 2 Diabetes

Skin pigmentation related variants in Mexican population and interaction effects on serum 25(OH)D concentration and vitamin D deficiency

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