Vitamin D Restores Skeletal Muscle Cell Remodeling and Myogenic Program: Potential Impact on Human Health

Crescioli, Clara

doi:10.3390/ijms22041760

Cited by 9 publications

(6 citation statements)

References 97 publications

(133 reference statements)

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“…Moreover, tissue repair is supported by various nutritional factors. For example, a low level of vitamin D has been associated with maladaptation of skeletal muscle and bone tissue [ 42 ]. Proper muscle renewal in response to exercise is required for optimal hypertrophic effects [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with high-level endurance performance: An expert consensus derived via the Delphi technique

Konopka

Solberg²,

Delhaije

et al. 2022

PLoS ONE

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There is little agreement on the factors influencing endurance performance. Endurance performance often is described by surrogate variables such as maximum oxygen consumption, lactate threshold, and running economy. However, other factors also determine success and progression of high-level endurance athletes. Therefore, the aim was to identify the relevant factors for endurance performance assessed by international experts by adhering to a structured communication method (i.e., Delphi technique). Three anonymous evaluation rounds were conducted initiated by a list of candidate factors (n = 120) serving as baseline input variables. The items that achieved ≥70% of agreement in round 1 were re-evaluated in a second round. Items with a level of agreement of ≥70% in round 2 reached consensus and items with a level of agreement of 40–69% in round 2 were re-rated in a third round followed by a consensus meeting. Round 1 comprised of 27 panellists (n = 24 male) and in round 2 and 3 18 (n = 15 male) of the 27 panellists remained. Thus, the final endurance expert panel comprised of 18 international experts (n = 15 male) with 20 years of experience on average. The consensus report identified the following 26 factors: endurance capacity, running economy, maximal oxygen consumption, recovery speed, carbohydrate metabolism, glycolysis capacity, lactate threshold, fat metabolism, number of erythrocytes, iron deficiency, muscle fibre type, mitochondrial biogenesis, hydrogen ion buffering, testosterone, erythropoietin, cortisol, hydration status, vitamin D deficiency, risk of non-functional overreaching and stress fracture, healing function of skeletal tissue, motivation, stress resistance, confidence, sleep quality, and fatigue. This study provides an expert-derived summary including 26 key factors for endurance performance, the “FENDLE” factors (FENDLE = Factors for ENDurance Level). This consensus report may assist to optimize sophisticated diagnostics, personalized training strategies and technology.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, tissue repair is supported by various nutritional factors. For example, a low level of vitamin D has been associated with maladaptation of skeletal muscle and bone tissue [42].…”

Section: Injury and Nutritionmentioning

confidence: 99%

Factors associated with high-level endurance performance: An expert consensus derived via the Delphi technique

Konopka

Solberg²,

Delhaije

et al. 2022

PLoS ONE

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“…Indeed, general important concerns still exist in several aspects, including the lack of a clear indication of the optimal dose requirement to respond to extra-skeletal needs, or the lack of a clear definition of vitamin D insufficiency/deficiency, based on well-defined serum ranges (still missing as well) [ 151 , 152 , 153 ]. Data from trials on D hormone supplementation, either alone or combined, are unsatisfactory likely due to the high variability in protocols and heterogeneity of the studied populations, since general health status, ethnicity, sedentary habit are often not defined, as recently summarized elsewhere [ 80 , 81 ]. Furthermore, recent evidence highlights the major role of exercise-induced sex-dependent heart remodeling during life of men and women at different ages, either sedentary or physically active [ 129 ].…”

Section: Discussionmentioning

confidence: 99%

“…It should be kept in mind that vitamin D is a molecule with quite a special identity, presenting features typical of a nutrient, a hormone and a rapid regulating factor; it is able to affect human health through a fine-tuned regulation of cell functions, by actively participating in biomolecule networking, as recently reported [ 80 , 81 , 82 ].…”

Section: Cardiovascular Health Beyond Sex Hormones: Vitamin D Mattersmentioning

confidence: 97%

The Role of Estrogens and Vitamin D in Cardiomyocyte Protection: A Female Perspective

Crescioli

2021

Biomolecules

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Women experience a dramatical raise in cardiovascular events after menopause. The decline in estrogens is pointed to as the major responsible trigger for the increased risk of cardiovascular disease (CVD). Indeed, the menopausal transition associates with heart macro-remodeling, which results from a fine-tuned cell micro-remodeling. The remodeling of cardiomyocytes is a biomolecular response to several physiologic and pathologic stimuli, allowing healthy adaptation in normal conditions or maladaptation in an unfavorable environment, ending in organ architecture disarray. Estrogens largely impinge on cardiomyocyte remodeling, but they cannot fully explain the sex-dimorphism of CVD risk. Albeit cell remodeling and adaptation are under multifactorial regulation, vitamin D emerges to exert significant protective effects, controlling some intracellular paths, often shared with estrogen signaling. In post-menopause, the unfavorable association of hypoestrogenism-D hypovitaminosis may converge towards maladaptive remodeling and contribute to increased CVD risk. The aim of this review is to overview the role of estrogens and vitamin D in female cardiac health, speculating on their potential synergistic effect in cardiomyocyte remodeling, an issue that is not yet fully explored. Further learning the crosstalk between these two steroids in the biomolecular orchestration of cardiac cell fate during adaptation may help the translational approach to future cardioprotective strategies for women health.

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“… 14 , 15 Studies have shown that VDR plays an important role in cardiovascular and neurodegenerative diseases, skeletal muscle cell remodeling, muscle regeneration, and inflammatory bowel disease. 16 , 17 In addition, VDR has a protective effect on the kidneys. 18 There is a relative lack of VDR in some kidney-related diseases such as glomerulonephritis, acute kidney injury, and DKD.…”

Section: Introductionmentioning

confidence: 99%

Metformin Ameliorates Epithelial–Mesenchymal Transition of Renal Tubular Epithelial Cells in Diabetes by Increasing Vitamin D Receptor Expression

Wen¹,

Huang²,

Ye³

2022

DMSO

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Background: Metformin is used as a first-line drug for the treatment of type 2 diabetes. Epithelial-mesenchymal transition (EMT) plays a significant role in the development of renal tubular damage in diabetic kidney disease. However, the underlying mechanisms of EMT in diabetic kidney disease are unclear and how to inhibit this process remains to be explored. Methods: C57 mice were randomly divided into four groups, including the normal control group (NC group), the Type 2 diabetes group (T2DM group), the metformin group (MET group), and glibenclamide group (GLIB). Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), urinary albumin, RBP, PCX, and creatinine were measured. Renal pathology was observed with HE staining. Molecular mechanism of VDR expression are regulated by metformin through wound healing assay, and Western blot analysis of VDR, Ecad, and SMA in HK2 cells. Results:In animal experiments, compared with the NC group, the T2DM group showed decreased body weight, increased levels of FBG, HbA1c, UAlb/UCR, URBP/UCR, and UPCX/UCR, decreased levels of VDR protein and mRNA expression in renal tissues (P < 0.05), and significantly increased renal pathological damage in mice in the T2DM group. Compared with the T2DM group, mice in the GLIB and MET groups had higher body weight and lower FBG, HbA1c, UAlb/UCR, URBP/UCR, and UPCX/UCR (P < 0.05). In addition, renal pathological damage was significantly reduced in the MET group compared to the GLIB group. In HK2 cells, high glucose promoted the reduction of VDR and the development of EMT compared to the NC group. In addition, we found that Metformin can up-regulate VDR and inhibit EMT. Conclusion:Our study shows that the renoprotective effect of metformin is independent of glycemic control and metformin is involved in the progression of EMT by regulating VDR expression.

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Vitamin D Restores Skeletal Muscle Cell Remodeling and Myogenic Program: Potential Impact on Human Health

Cited by 9 publications

References 97 publications

Factors associated with high-level endurance performance: An expert consensus derived via the Delphi technique

Factors associated with high-level endurance performance: An expert consensus derived via the Delphi technique

The Role of Estrogens and Vitamin D in Cardiomyocyte Protection: A Female Perspective

Metformin Ameliorates Epithelial–Mesenchymal Transition of Renal Tubular Epithelial Cells in Diabetes by Increasing Vitamin D Receptor Expression

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