Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons

Pértile, Renata Aparecida Nedel; Cui, Xiaoying; Hammond, Luke A.; Eyles, Darryl W.

doi:10.1096/fj.201700713r

Cited by 58 publications

(62 citation statements)

References 57 publications

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“…33 Vitamin D could protect the dopamine system by modulating GDNF receptor, C-Ret, which is greatly important for cell differentiation and survival of dopaminergic neurons. 34 These studies suggested that vitamin D deficiency in fetuses or early brain development might be contributing to the etiology of tic disorders.…”

Section: Discussionmentioning

confidence: 99%

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

Wang

et al. 2019

NDT

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Purpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level. Results: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions. Conclusion: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.

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Section: Discussionmentioning

confidence: 99%

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

Wang

et al. 2019

NDT

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“…Vitamin D has also been related to synthesis of monoamines (serotonin, dopamine, and noradrenaline) and its steroidal features may allow it to modulate the activity of GABA‐A receptors (Bertone‐Johnson, 2009; Humble, 2010; Maguire, Ferando, Simonsen, & Mody, 2009; Marsh, Penny, & Rothschild, 2017; Panzica & Melcangi, 2008; Patrick & Ames, 2014). In addition several studies have shown that vitamin D is associated with nerve growth factor enhancement and antioxidant effects in the central nervous system (Humble, 2010; Moradi, Sohrabi, Taheri, Khodashenas, & Movahedi, 2018; Pertile, Cui, Hammond, & Eyles, 2018; Sepehrmanesh et al, 2016). It is therefore biologically plausible that vitamin D would have psychiatric applications and the possibilities are worthy of investigation (Bertone‐Johnson, 2009; Humble, 2010).…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Cheng

Huang

2020

Depress Anxiety

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Background The several meta‐analyses of the effect of vitamin D on depression have produced inconsistent results and studies dealing with anxiety were not incorporated. There has been no comprehensive analysis of how results are affected by the nature of the sample or the dosage and duration of supplementation. The study is aimed to investigate whether vitamin D supplementation reduces negative emotions and to analyze the possible influence of sample and regimen. Method We conducted a systematic review and meta‐analysis of randomized controlled trials comparing the effect of vitamin D and placebo on negative emotion. Databases were searched for relevant articles published before February 2019. Results The analysis covered 25 trials with a total of 7,534 participants and revealed an effect of vitamin D on negative emotion (Hedges' g = −0.4990, 95% CI [−0.8453, −0.1528], p = .0047, I2 = 97.7%). Subgroup analysis showed that vitamin D had an effect on patients with major depressive disorder and on subjects with serum 25(OH)D levels ≤50 nmol/L. The pooled data from trials of vitamin D supplementation lasting ≥8 weeks and dosage ≤4,000 IU/day indicated that vitamin D had an effect. Conclusions Our results support the hypothesis that vitamin D supplementation can reduce negative emotions. Patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation. But to interpret the results with high heterogeneity should still be cautious.

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“…GDNF has been shown to be an important neuroprotective factor, and increased levels of GDNF have been demonstrated after treatment with calcitriol in models of oxidative brain injury [34] and autoimmune encephalitis [35]. Treating neuronal cells with calcitriol also increases levels of c-Ret mRNA, a GDNF receptor [36]. Additionally, pups born to vitamin D-deficient dams demonstrate lower levels of GDNF [13].…”

Section: Vitamin D and The Injured Brainmentioning

confidence: 99%

Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury

Stessman

Peeples

2018

Neonatology

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Emerging evidence has demonstrated that vitamin D plays an important role in many adult neurologic disorders, but is also critical in neuronal development and pruning in the neonatal and pediatric populations. Neonates are at a particularly high risk of vitamin D deficiency, in part due to the high prevalence of maternal deficiency during pregnancy. Several preclinical studies have demonstrated that infants born to vitamin D-deficient mothers are at a high risk of developing neonatal brain injury, and recent clinical studies have shown that neonates with hypoxic-ischemic encephalopathy (HIE) tend to be vitamin D-deficient. There are limited data, however, on whether additional prenatal or postnatal supplementation may alter the prevalence or severity of neonatal HIE. This review examines the current data supporting the neuroprotective role of vitamin D, with a focus on how these findings may be translated to neonates with HIE.

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Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons

Cited by 58 publications

References 57 publications

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

<p>Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders</p>

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury

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