Vitamin D receptor polymorphisms in spontaneous preterm birth: a case-control study

Abstract

Aim To evaluate the association between the FokI (rs2228570), ApaI (rs7975232), Bsml (rs1544410), TaqI (rs 731236), and Cdx2 (rs11568820) single nucleotide polymorphisms (SNPs) in the vitamin D receptor ( VDR ) gene and spontaneous preterm birth (SPTB), as well as their effect on clinical characteristics of women with SPTB and their newborns. Methods This case-control study enrolled women who gave birth at the Department of Obstetrics and Gynecology, University Medical Center Ljubljana between 2010 to 2019. Cases were 118 women with spontaneous initiation of PTB after natural conception and 119 controls with a term singleton delivery after an uncomplicated pregnancy. The molecular analysis of VDR SNPs employed polymerase chain reaction and restriction fragment length polymorphism. Results Patients and controls did not significantly differ in the distribution of genotype or allele SNP frequencies. However, the FokI polymorphism had a significant effect on newborn birth weight in women with SPTB but not in controls (F = 5.17, P = 0.007, one-way ANOVA with post-hoc Scheffe test), with newborns of FokI TT carriers having the lowest birth weight ( P = 0.011). No other VDR SNP was associated with any other clinical characteristic of women with SPTB and their newborns. Conclusion The TT genotype of the VDR FokI polymorphism is associated with newborn birth weight in women of European origin with SPTB.

Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box

“…Vitamin D maintains its function through vitamin D receptors (VDR), which polymorphism was associated with spontaneous preterm birth in Northeastern Brazilians [ 142 , 143 , 144 ]. Furthermore, a role for VDR and signaling pathways in the placenta was proposed [ 142 ], and reduced VDR expression was seen in the chorionic villi and decidua in women with RPL compared with control women [ 142 , 145 ].…”

The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women

“…Thus far, several publications have analyzed the relationship of VDR gene polymorphisms with the occurrence of certain complications in pregnancy [ 27 ]. It has been suggested that VDR polymorphism could be associated with the occurrence of gestational diabetes [ 51 , 52 , 53 ], preterm labor [ 54 ], recurrent miscarriages [ 55 , 56 ], gestational cholestasis [ 40 ], and intrauterine fetal restriction that often coexisted with PE and placental insufficiency [ 27 ]. Thus far, however, no unequivocal results have been obtained determining the importance of VDR gene variants in the pathways influencing the placenta function, regulating implantation, hormone secretion, or immune modulation.…”