Vitamin D receptor polymorphism (−1056 Taq‐I) interacts with smoking for the presence and progression of periodontitis

Nibali, Luigi; Parkar, MH; D’Aiuto, Francesco; Suvan, Jean; Brett, Peter; Griffiths, Gareth; Rosin, Michael; Schwahn, Christian; Tonetti, Maurizio S.

doi:10.1111/j.1600-051x.2008.01233.x

Cited by 44 publications

(39 citation statements)

References 30 publications

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“…In particular, the TT genotype and the presence of T allele are associated with chronic periodontal disease in Japanese, Chinese and Caucasian subjects (23)(24)(25)(26)(27). This data is also in accordance with our previous study which showed a strong correlation between TT genotype of Italian subjects and chronic periodontitis (OR 3.59) but also with aggressive periodontal disease (28).…”

Section: Taqisupporting

confidence: 81%

Vitamin D: relevance in dental practice

Martelli¹

2014

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SummaryObjective. The potential role of VDR gene variations in modulating periodontal susceptibility have been a subject of scientific investigations. The aim of this paper is to perform a literature review of the potential correlation between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease. Materials and methods. A PubMed literature search was made using "vitamin d receptor polymorphisms periodontal disease" as keys words. Only clinical studies in "Humans" as species and "English" as language were considered. Titles and abstracts of all identified records were examined to determine if the candidate articles contained sufficient information on the association of the VDR polymorphisms and the risk of development periodontal disease. Conclusions. Vitamin D may affect the risk of developing periodontal disease via an effect on bone mineral density or via immunomodulatory effects. There are scientific evidences about the correlation between some VDR polymorphisms, periodontitis and bone metabolism. The use of new simple and economics diagnostic techniques of genetic screening, allows to the dental specialists to identify periodontal patients with possible decreased bone mineral density. The complete acquisition of awareness by dentists of the strong relationship between skeletal bone density with periodontal health and osteointegrated implant success, could open a new therapeutic approach for periodontists with an important role in the early detection of osteoporosis and a better patient compliance of the periodontal therapy.

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Section: Taqisupporting

confidence: 81%

Vitamin D: relevance in dental practice

Martelli¹

2014

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“…In a recent longitudinal study, Nibali et al [32] found a moderate association between VDR Taq-I polymorphism and periodontitis presence/progression in smokers but no association in non-smokers, concluding that VDR genetic factors may interact with smoking in the pathogenesis of periodontitis [32]. In our study, the association of different BsmL haplotypes was not significant when the analysis controlled for tobacco consumption, age, and number of teeth present.…”

Section: Discussioncontrasting

confidence: 45%

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

Mesa

González

Souki³

et al. 2011

Clin Oral Invest

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The objective of this study was to determine, using digital panoramic radiographs, whether the bone level at the alveolar crest is related to the mandibular bone density and/or to vitamin D receptor (VDR) gene polymorphisms. We analyzed 319 digital panoramic radiographs from the same number of patients. Alveolar bone level was expressed as percentage of root length. The mandibular cortical width index was calculated as a measure of mandibular bone density, and, in 72 randomly selected cases, the haplotype of the VDR gene (BsmL) was determined by polymerase chain reaction. Alveolar bone level was not related to the mandibular cortical width index (p = 0.568) or VDR gene expression (p = 0.575). Bone loss was greater in smokers than in non-smokers (p = 0.036), and the mandibular cortical width index was higher in males (p = 0.04), the older age group (p = 0.032), and in those with more teeth (p = 0.01). Multivariate analysis confirmed the association between these variables and alveolar bone loss. Alveolar bone loss showed no significant relationship with the mandibular bone density evaluated on digital panoramic radiographs or with VDR genotype (BsmL) in Caucasian females and males aged under 47 years.

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“…Several studies have revealed the presence of particular VDR gene allelic forms which influence the frequency of periodontitis. TaqI polymorphism in VDR gene, particularly the of TT genotype, was associated with an increased risk of chronic periodontitis (CP) as reported by Tachi et al (2003), Wang et al (2009), Brett et al (2005), Nibali et al (2008 and Martelli et al (2011) while Toniato Borges et al (2009 observed a higher incidence of CP in patients with Tt genotype. Sun et al (2002) suggested the involvement of Tt genotype in the development of early-onset periodontitis.…”

Section: Periodontitismentioning

confidence: 71%

Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

Ślebioda

Szponar

Dorocka‐Bobkowska

2016

Arch. Immunol. Ther. Exp.

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Vitamin D belongs to a group of fat-soluble secosteroids which assume many roles in the human organism. In humans the most important forms are vitamin D3 and vitamin D2. Their primary function is the regulation of the calcium and phosphorus balance, which promote the growth of healthy bony tissue. Studies over the past few years have revealed a much wider role of vitamin D involving the aging processes, carcinogenesis, the carbohydrate balance as well as the effects on the course of various infections. In this paper we discuss the basic functions of vitamin D in the human body and the mechanisms of its activity and we summarize recent reports on the impact of vitamin D on the oral cavity with a special emphasis on autoimmunologic diseases, including: recurrent aphthous stomatitis, Behçet syndrome and Sjögren syndrome.

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Vitamin D receptor polymorphism (−1056 Taq‐I) interacts with smoking for the presence and progression of periodontitis

Abstract: Vitamin D receptor Taq-I TT polymorphism was moderately associated with both the presence and the progression of periodontitis in smokers, while no association was detected in non-smoking individuals. VDR genetic factors may interact with smoking in the pathogenesis of periodontitis.

Cited by 44 publications

References 30 publications

Vitamin D: relevance in dental practice

Vitamin D: relevance in dental practice

Alveolar bone level is not associated with vitamin D receptor gene polymorphism and bone density in mandible

Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases

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