Vitamin D Receptor <i>Fok1</i> Polymorphisms Affect Calcium Absorption, Kinetics, and Bone Mineralization Rates During Puberty

Abrams, Steven A.; Griffin, Ian J.; Hawthorne, Keli M.; Chen, Zhensheng; Gunn, Sheila; Wilde, Margaret; Darlington, Gretchen; Shypailo, Roman J.; Ellis, Kenneth J.

doi:10.1359/jbmr.050114

Cited by 121 publications

(88 citation statements)

References 39 publications

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“…Vitamin D receptor Fok1 polymorphisms are significantly related to calcium absorption and whole body BMC in adolescents. (40) Race may be a crude indicator of genes that regulate body size, but habitual calcium intake and skin color may also be indicators in some cohorts.…”

Section: Barriers To Determining the Role Of Vitamin D Status On Skelmentioning

confidence: 99%

Vitamin D, Calcium Homeostasis, and Skeleton Accretion in Children

Weaver

2007

Journal of Bone and Mineral Research

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Overt vitamin D deficiency early in life has classically been associated with the etiology of rickets. Recent interest has focused on vitamin D insufficiency and calcium homeostasis and bone health. A review of the literature suggests that the relationship between vitamin D status and calcium utilization has some important differences with life stage and race. In contrast to adults, serum 1,25-dihydroxyvitamin D, but not serum 25-hydroxyvitamin D, predicts calcium absorption in growing children. PTH suppression with increasing serum 25-hydroxyvitamin D varies with race in adolescents. A limitation of our understanding of vitamin D status on calcium homeostasis in children relates to the cross-sectional nature of the evidence and interventions that typically use too little vitamin D supplementation to affect status. Vitamin D status has predicted changes in BMD during growth, and higher doses have been associated with increased bone area and BMC of the hip in pubertal girls with low baseline vitamin D status. Bone accretion is related to calcium status, sexual maturity, race, and genetics. Current cross-sectional studies in children suggest that vitamin D status is less important for bone accrual than for bone health in adults. Intervention studies are needed to identify responsive groups.

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Section: Barriers To Determining the Role Of Vitamin D Status On Skelmentioning

confidence: 99%

Vitamin D, Calcium Homeostasis, and Skeleton Accretion in Children

Weaver

2007

Journal of Bone and Mineral Research

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“…Moreover, Yu et al (42) indicated that Chinese women with the FF genotype regained more BMD after calcium supplementation. According to experimental studies, FOK1 can significantly affect the whole body BMD in those with a Ca intake.800 mg/d, while for those with a Ca intake800 mg/d, the FOK1 genotype did not have a significant effect on whole body BMD (43). Our evidence suggested that women with vitamin D intakes of less than 600 IU/d and the ff genotype had a higher total T-score and total Z-score, although, women with a vitamin D intake of more than the recommended dietary allowance (RDA.600 IU/d) and the FF genotype had a higher total T-score and total Z-score (Fig.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Moradi

Khorraminezhad

Maghbooli

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Osteoporosis and fragility fractures have been regarded as important public health concerns. We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake. A total of 264 Iranian obese women (BMI.30 kg/m 2 ) were categorized based on the FOK1 genotype and divided into two groups: group one with the FF genotype (n5184) and the f allele carrier group with the Ff or ff genotype (n580). The body composition, dietary intake and bone mineral density were assessed for all cases. The frequency of the F and f alleles for FOK1 in the study were 71.5% and 28.5%, respectively. Women with the f allele had a higher BMI (p50.05), as well as parathyroid hormone (PTH) and tumor necrosis factor alpha (TNF-a) concentration (p50.05, p50.01, respectively). Participants with calcium intakes of more than 1,000 mg/d and the ff genotype had a higher L2_L4 Z-score. Moreover, women with vitamin D intakes of less than 600 IU/d and the ff genotype had a higher total T-score and total Z-score. Although women whose dietary intake of vitamin D was higher than the recommended dietary allowance (RDA.600 IU/d) and had the FF genotype had a higher total T-score and total Z-score, as well. Our findings suggest that interactions between FOK1 polymorphisms in Iranian obese women and dietary intake of calcium and vitamin D may play a decisive role in bone mineral density and osteoporosis among these women.

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“…This indicates that BMD is not solely dependent upon genetic factors, but also upon environmental ones, such as calcium intake [23]. Results of studies on the matter are however somewhat conflicting.…”

Section: Discussionmentioning

confidence: 99%

Selected risk factors of fractures in children — own observation

Jakubowska-Pietkiewicz

Fendler

Młynarski

et al. 2012

Open Medicine

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AbstractBone fractures may depend on Vitamin D Receptor Gene (VDR), bone mineral density, bone turnover markers. Patients and methods. 161 patients were recruited and underwent: skeletal densitometry (DXA) method and bone turnover studies (Osteocalcin and Ntx).The study group was evaluated using restriction enzyme digestion at BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), polymorphic sites of the VDR gene. Multivariate logistic regression was used to assess factor significance. The model included variables with sex- and age-standardized parameters, VDR genotypes, and bone metabolism marker levels. Results. Factors associated with fractures were: osteocalcin concentration and Z-score BMDt. Odds Ratio (OR) values equaled: 1.01 (95%Confidence Interval (95%CI) 1.00–1.02) for osteocalcin (p=0.006), and 0.66 (95%CI 0.42-1.03; p=0.07) for Z-score BMDt. In patients with reduced bone mass, factors related to fractures were: osteocalcin (0.04) and carriage of BsmI b (0.07) or ApaI a alleles (0.08). ORs were 1.01 (95%CI 1.00–1.02) for OC, 0.29 (95%CI 0.07–1.14) for BsmI, and 2.13 (95%CI 0.91–4.99) for ApaI polymorphic allele carriage. Conclusions. Carriage of BsmI b allele reduces, while carriage of ApaI a allele and heightened osteoclacin level increase the risk of fractures in study children with reduced bone mass. VDR polymorphism, bone mineral density and bone formation’s marker — osteocalcin maybe considered as risk factor for fracure in children from Lodz region.

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Vitamin D Receptor Fok1 Polymorphisms Affect Calcium Absorption, Kinetics, and Bone Mineralization Rates During Puberty

Cited by 121 publications

References 39 publications

Vitamin D, Calcium Homeostasis, and Skeleton Accretion in Children

Vitamin D, Calcium Homeostasis, and Skeleton Accretion in Children

Vitamin D Receptor Gene Variation, Dietary Intake and Bone Mineral Density in Obese Women: A Cross Sectional Study

Selected risk factors of fractures in children — own observation

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