Vitamin D Receptor<i>Bsm</i>I Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Jia, Fu; Sun, Ruili; Li, Qun-Hui; Wang, Daxing; Zhao, Feng; Li, Junmin; Qin, Pu; Zhang, Zhong-Zi; Yan, Ji; Liu, Bai-Lian; Xiong, Ying

doi:10.1089/gtmb.2012.0267

Cited by 47 publications

(38 citation statements)

References 40 publications

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“…VDR polymorphisms have been among the most widely SNPs studied in OP. In particular, BsmI has shown inconsistent results with respect to its association with BMD (Thakkinstian et al, 2004;Zintzaras et al, 2006;Li et al, 2012;Jia et al, 2013;Qin et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

González-Mercado

Sánchez-López²,

Regla-Nava³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified according to World Health Organization criteria as non-osteoporotic (Non-OP; N = 88), osteopenic (Opn; N = 144), and osteoporotic (OP; N = 88). BMD measurements at the lumbar (L1-L4) spine and at the left and right femoral neck were obtained by dual-energy X-ray absorptiometry. Single nucleotide polymorphisms (SNPs) were genotyped using real-time polymerase chain reaction and TaqMan probes. Genotype and allelic frequencies of the 4 VDR SNPs were similar among the 3 groups. Polymorphic allele frequencies were as follows: FokI (C) 0.53, 0.49, 0.56; BsmI (A) 0.26, 0.22, 0.23; ApaI (T) 0.43, 0.39, 0.44; TaqI (C) 0.27, 0.22, 0.23 for the Non-OP, Opn, and OP groups, respectively. Although no associations were found between the SNPs and BMD, based on the putative function of the FokI SNP, we constructed, for the first time, the haplotype with the 4 VDR SNPs, and found that the CGGT haplotype differed between the Non-OP and OP groups (21.8 vs 31.8%, P < 0.05). The risk analysis for this haplotype was nearly significant under the dominant model (OR = 1.783, 95%CI = 0.98-3.25, P = 0.058). This result suggests a possible susceptibility effect of the C allele of the FokI SNP for the development of osteoporosis in postmenopausal Mexican-Mestizo women.

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Section: Discussionmentioning

confidence: 99%

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

González-Mercado

Sánchez-López²,

Regla-Nava³

et al. 2013

Genet. Mol. Res.

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“…Dozens of studies have been performed looking at the possible association of vitamin D receptor (VDR) polymorphisms with BMD and fractures, with discordant results. The controversy has not been solved after several meta-analyses [55][56][57][58][59] .…”

Section: Genetic Factors Influencing Drug Responsementioning

confidence: 99%

Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis

López-Delgado¹,

Riancho‐Zarrabeitia²,

Riancho³

2016

Expert Opinion on Drug Metabolism & Toxicology

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“…Base on VDR biological functions, FokI can be seen as a candidate gene for osteoporosis. Accumulating studies have investigated the association between this polymorphism and osteoporosis [17,18]. However, the results were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Zhang

Ning

et al. 2015

J Osteopor Phys Act

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Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods:Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance. Results:The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessive model had increased risk of osteoporosis in Asian subjects(OR=2.644, 95% CI: 1.583~4.419,p= 0.000),but not in Caucasian subjects(OR= 1.288, 95%CI: 0.783~2.118, p = 0.318) and Mixed subjects (OR= 0.885, 95%CI: 0.686~1.141, p =0.346). A symmetric funnel plot, the Begg-test (P=0.094) suggested that lack of publication bias. The studies conducted in each of the defined number of osteoporosis-had no effect of the FokI polymorphism on osteoporosis except for the ff versus Ff+FF genotype comparison for osteoporosis subgroup. Conclusion:In conclusion, our meta-analysis suggests that VDR Fok I genotype is associated with increased risk of osteoporosis in Asian but not in caucasian. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR Fok I polymorphism and osteoporosis.

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Vitamin D ReceptorBsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Abstract: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.

Cited by 47 publications

References 40 publications

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

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