Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: a new pattern from Khorasan province, Islamic Republic of Iran

Abstract

Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. We studied the association between type 1 diabetes and 4 VDR gene polymorphisms (Bb, Ff, Aa and Tt) in an Iranian population. A group of 69 patients with type 1 diabetes mellitus and 45 unrelated healthy subjects were recruited. The prevalence of VDR polymorphisms in 4 restriction fragment length polymorphism sites including BsmI, FokI, ApaI and TaqI were analysed in patients and controls. The frequencies of 3 genotypes (Aa, FF and Bb) were significantly higher in the patient group. The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. There were no significant difference between the genotype frequencies and chronic complications of diabetes, but the relationship between the Ff genotype and ketoacidosis was significant. Our results differ from previous polymorphism studies in other regions.

Effect of Vitamin D3 Supplement in Glycemic Control of Pediatrics with Type 1 Diabetes Mellitus and Vitamin D Deficiency

“…Two studies in Iran suggest polymorphism of vitamin D receptor genes in type I diabetes mellitus [21,22]. In our study positive family history for two types of diabetes were 38.73% and changes in HbA1C and 25OHD did not differ in relatives and non-relatives (p-value>0.05).…”

Association of Genetic Polymorphisms in a Sample of Iraqi Patients with Type1 Diabetes mellitus

“…In assessment of the results for the family history of diabetes in this study revealed that T1D for a parental history was 6.7% (4 out of 60),for the relatives was 18.3% (11 out of 60);The study by Fujisawa et al(2004) reported that 22% with T1D have a parental history of diabetes compared to control 7% and this revealed that the family history in patients in T1D increased when compared with healthy controls (Fujisawa et al, 2004). (Bonakdaran et al, 2012). Patients from Germany in Frankfurt also demonstrated that VDR FoK-I ff allele and Ff genotype were positively associated with the disease (Morán et al, 2015).…”

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

“…To date, there are 65 publications [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83] on the association of VDR gene SNPs in T1D: these include case-control datasets [20,22,23,25,26,27,28,…”

“…A total of 39 publications support an association between VDR SNPs rs7975232 ( ApaI ), rs1544410 ( BsmI ), rs731236 ( TaqI ) and rs10735810 ( FokI ) alone or in combination with each other, (rs757343 Tru9I , rs1540339 and rs4760648) and T1D [19,21,22,23,24,26,27,28,29,30,34,35,36,37,38,40,41,42,43,44,46,48,49,50,52,53,55,56,59,60,61,62,63,65,68,69,70,71,73] (Table 2) in comparison with 16 studies that refute it [20,25,31,32,39,45,47,51,54,57,58,64,66,67,72,74]. …”