Vitamin D receptor gene polymorphisms in atopy

Tamašauskienė, Laura; Golubickaitė, Ieva; Ugenskienė, Rasa; Sjakste, Nikolajs; Paramonova, Natalia; Wu, Lawrence Shih-Hsin; Wang, Lawrence Shih-Jiu-Yao; Šitkauskienė, Brigita

doi:10.1002/iid3.487

Cited by 7 publications

(6 citation statements)

References 45 publications

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“…VDR gene, located on the long arm of chromosome 12, has polymorphisms in various diseases which may influence vitamin D function. Some of these VDR polymorphisms influence the severity and susceptibility of AD, as confirmed by the identification of a polymorphism present in patients with severe AD, therefore indicating that VDR and vitamin D may contribute to AD control 14,15,[27][28][29] .…”

Section: The Role Of Vitamin D In Admentioning

confidence: 81%

Atopic dermatitis and vitamin D

Rodrigues,

Gonçalo

2024

PJDV

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Atopic dermatitis (AD) results from the interaction between dysfunction of the skin barrier, dysregulation of the immune system, and alteration of the skin microbiome. As the most common inflammatory skin disease worldwide and still increasing, it is a real health problem. Vitamin D deficiency is also considered a global problem affecting 13 out of 100 people in Europe. Since vitamin D is involved in the formation of the epidermal barrier, by the synthesis of structural proteins and regulation of keratinocyte proliferation and differentiation, there is a rational to evaluate the relation between vitamin D levels and the prevention or treatment of AD. The authors performed a review of the existing scientific literature on the role of vitamin D in AD. Although studies are scarce not very robust with no consensual results, most studies report lower serum levels of vitamin D in patients with AD. In addition, there seems to be an inverse relationship between plasma levels of vitamin D and clinical severity, a hypothesis that is reinforced by studies that demonstrated a statistically significant benefit of vitamin D supplementation for improving clinical symptoms and signs of AD. Some studies also suggest a possible influence of prenatal vitamin D levels on the onset of AD during childhood. Therefore, vitamin D supplementation may play a relevant role as a complement to the treatment of AD or for its prevention, but more and better scientific evidence is needed to confirm this.

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Section: The Role Of Vitamin D In Admentioning

confidence: 81%

Atopic dermatitis and vitamin D

Rodrigues,

Gonçalo

2024

PJDV

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“…In addition, studies have confirmed that vitamin D receptor gene polymorphism may also affect vitamin D levels. 22 However, there is also controversy regarding the vitamin D status in overweight/obese AD patients. The comparative study showed that obesity was a risk factor for asthma, but not for AD, allergic rhinitis, and sensitization.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study

Chen,

Fang,

Liu

et al. 2024

International Journal of Dermatology and Venereology

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Objective: To assess the relationship between the severity of atopic dermatitis (AD) in children of varying weight categories and their serum 25-hydroxyvitamin D [25(OH)D] levels. Methods: The study population comprised 899 patients with AD and 854 age- and sex-matched controls. The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups, and Spearman correlation analysis was used to test correlation. Results: The 25(OH)D level in the AD group was M (Q 25, Q 75), 24.0 (19.7, 28.4) ng/mL, which was significantly lower than the control group (26.4 [23.6, 29.9] ng/mL; Z = −3.34, P = 0.001). 25(OH)D levels in children with AD were negatively correlated with body mass index (r = −0.30, P < 0.001), Severity scoring of Atopic Dermatitis (SCORAD; r = −0.14, P < 0.001), total immunoglobulin E (r = −0.13, P < 0.001), and eosinophil (r = −0.08, P = 0.017). There were statistically significant differences in 25(OH)D (H = 18.46, P < 0.001), total immunoglobulin E (H = 9.13, P = 0.010), eosinophil (H = 67.17, P < 0.001), and SCORAD (H = 10.49, P = 0.005) among groups with different body mass index classification. The 25(OH)D levels were 22.3 (17.5, 27.1) ng/mL in the overweight AD group and 22.3 (17.6, 25.7) ng/mL in the obese AD group, which were significantly lower than those in the normal-weight AD group (24.7 [20.4, 25.5] ng/mL; P = 0.003, P = 0.004). 25(OH)D levels were negatively correlated with SCORAD in obese AD patients (r = −0.25, P = 0.010). Conclusion: Vitamin D insufficient or deficient is obvious in children AD patients. The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group. Vitamin D level is negatively correlated with SCORAD in obese children with AD.

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“…Vitamin D possesses essential functions such as regulating calcium and phosphorus metabolism, contributing in the development of a strong immune system, and preventing oxidative DNA damage and cancer development by inducing apoptosis in tumor-forming cells 13,14 . Studies in the literature have reported vitamin D deficiency to be a common phenomenon in pregnant women 11,12 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin and mineral levels during pregnancy

Hansu¹,

Çıkım

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Numerous physiological changes occur during pregnancy, which affect both the mother and the fetus. The objective of this study was to evaluate the magnesium, calcium, phosphate, parathormone (PTH), and vitamin D levels in each trimester of pregnancy. METHODS: In this study, 30 pregnant women in the first trimester, 30 pregnant women in the second trimester, 30 pregnant women in the third trimester, and 30 healthy, non-pregnant women (control) in the same age group were included. The serum magnesium, calcium, phosphate, PTH, and vitamin D levels were measured in all the participants. RESULTS: No statistically significant difference was found in the PTH and phosphate levels within the groups. In contrast, a significant difference was found in the vitamin D, calcium, and magnesium levels (p<0.001 for all). By analyzing the differences between the groups, the vitamin D, calcium, and magnesium levels were found to decrease with increase in the gestational weeks. CONCLUSION: For maintaining a healthy pregnancy and fetus, we recommend vitamin D, calcium, and magnesium levels to be included in routine follow-ups for each trimester and supplemented in case of deficiency.

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Vitamin D receptor gene polymorphisms in atopy

Cited by 7 publications

References 45 publications

Atopic dermatitis and vitamin D

Atopic dermatitis and vitamin D

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study

Vitamin and mineral levels during pregnancy

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