Vitamin D Receptor Gene Polymorphism in Patients With Juvenile Rheumatoid Arthritis

Myslivets, M.G.; Парамонова, Н. С.; Stepuro, T. L.

doi:10.29256/01.03.2017.escbm07

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“…At the same time, it was shown that SNP ApaI ( T > G ) is associated with 25(OH)D levels in both men and women and that 25(OH)D levels were significantly lower in carriers of the TT genotype than in carriers of the GG genotype ( 60 ). The presence of the AA genotype of a polymorphic variant of BsmI is associated with a 1.84-fold increase in the risk of developing idiopathic arthritis (IA), with the presence of the A allele in the genotype being associated with a 1.34-fold increase in the probability of developing IA among patients without osteoarticular pathology ( 61 ). Kostik et al ( 62 ) reported that the BB BsmI genotype of the polymorphic marker of the VDR gene is associated with high disease activity, which can be considered as a marker of an unfavorable prognosis in boys with JIA.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

et al. 2022

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BackgroundJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1–18 years of age, with juvenile idiopathic arthritis (JIA) and a health control group of peers. We considered effects of endogenous, exogenous, and genetic factors on measured differences in vitamin D levels among children with JIA.MethodsOur findings are based on a study sample of 150 patients with various variants of JIA and 277 healthy children. The blood level of vitamin D was assessed by calcidiol level. The following factors were included in our analysis: age and sex; level of insolation in three regions of country (center, south, north); assessment of dietary intake of vitamin D; effect of prophylactic doses of cholecalciferol; a relationship between the TaqI, FokI, and BsmI polymorphisms of the VDR gene and serum 25(OH)D concentration.ResultsWe identified a high frequency of low vitamin D among children with JIA, prevalence of 66%, with the medial level of vitamin D being within the range of “insufficient” vitamin D. We also show that the dietary intake of vitamin D by children with JIA is well below expected norms, and that prophylactic doses of vitamin D supplementation (cholecalciferol) at a dose of 500–1,000 IU/day and 1,500–2,000 IU/day do not meet the vitamin D needs of children with JIA. Of importance, we show that vitamin D levels among children with JIA are not affected by clinical therapies to manage the disease nor by the present of VDR genetic variants.ConclusionProphylactic administration of cholecalciferol and season of year play a determining role in the development of vitamin D deficiency and insufficiency.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

et al. 2022

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Vitamin D Receptor Gene Polymorphism in Patients With Juvenile Rheumatoid Arthritis

Abstract: VITAMIN D RECEPTOR GENE POLYMORPHISM IN PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

Cited by 1 publication

References 2 publications

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study

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