Vitamin D receptor gene BsmIpolymorphisms in Thai patients with systemic lupus erythematosus

Sakulpipatsin, Wilaiporn; Verasertniyom, Oravan; Nantiruj, Kanokrat; Totemchokchyakarn, Kitti; Lertsrisatit, P.; Janwityanujit, Suchela

doi:10.1186/ar1910

Cited by 40 publications

(10 citation statements)

References 20 publications

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“…Another similar study in Taiwan with the population of 47 patients with SLE also found an increased distribution of VDR BB genotype in SLE, but indicated no association between the frequency of VDR allelic variations and clinical manifestations or laboratory proWles [6]. Sakulpipatsin et al did not show any association between VDR gene BsmI polymorphism and SLE in 101 Thai patients with lupus [2].…”

Section: Discussionmentioning

confidence: 92%

“…It has been demonstrated that VDR gene BsmI polymorphisms are genetic markers of SLE [2,[5][6][7]10]. A study in Japan of 58 patients with SLE found that BB genotype might trigger the development of SLE and that the bb genotype was associated with lupus nephritis [5].…”

Section: Discussionmentioning

confidence: 98%

“…Vitamin D deWciency correlates with many autoimmune diseases as well as multiple sclerosis, inXammatory bowel disease, rheumatoid arthritis and lupus [2,4,10]. 1,25-Dihydroxyvitamin D3 was shown to be therapeutically eVective in animal model of lupus [11].…”

Section: Discussionmentioning

confidence: 99%

“…It interferes with Th cell functions at the cellular level reducing Th induction of immunoglobulin production [2]. 1,25(OH) 2 D3 is thought to exert many of its actions through interaction with a speciWc intracellular receptor (VDR).…”

Section: Introductionmentioning

confidence: 99%

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Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus

Abbasi

Rezaieyazdi

Afshari³

et al. 2010

Rheumatol Int

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Several data link vitamin D to many autoimmune diseases. Association between vitamin D receptor (VDR) gene BsmI polymorphisms and systemic lupus erythematosus has been reported. In this study, we examine whether the VDR gene BsmI polymorphisms are markers for susceptibility to or severity of SLE. This study incorporated 60 patients with SLE living in northeastern Iran. Three genotypes, BB, Bb and bb, were detected based on polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP). The distribution of VDR genotyping in patients with SLE was 23.3% for BB, 60% for Bb and 16.7% for bb and in the control group was 33.3% for BB, 46.7% for Bb and 20% for bb (P = 0.334). No association of VDR gene BsmI polymorphisms with SLE disease activity index (SLEDAI), SLE damage score and major organ involvement was detected. The result of this study did not show any association between VDR gene BsmI polymorphisms and SLE.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus

Abbasi

Rezaieyazdi

Afshari³

et al. 2010

Rheumatol Int

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“…Neither vitamin D intake in adulthood 32 nor in adolescence 33 Case-control studies have examined the association between VDR polymorphisms and SLE with conflicting results, finding associations in some populations, 25 34-36 but not others. [37][38][39][40][41][42] No studies have examined the role of GC, CYP27B1 or CYP24A1 and the risk of SLE.…”

Section: Introductionmentioning

confidence: 99%

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

et al. 2016

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Objective We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE. Methods 436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (± 3.9) years later. Fifty-six individuals transitioned to SLE (≥4 cumulative ACR criteria). 25-hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single nucleotide polymorphisms (SNPs) in four vitamin D genes were genotyped. Generalized estimating equations, adjusting for correlation within families, were used to test associations between the vitamin D variables and the outcome of transitioning to SLE. Results Mean baseline 25[OH]D levels (p=0.42) and vitamin D supplementation (p=0.65) were not different between those who did and did not transition to SLE. Vitamin D deficiency (25[OH]D <20 ng/ml) was greater in those who transitioned compared to those who did not transition to SLE (46% versus 33%, p=0.05). The association between 25[OH]D and SLE was modified by CYP24A1 rs4809959, where for each additional minor allele, increased 25[OH]D was associated with decreased SLE risk: 0 minor alleles (adjusted OR:1.03, CI:0.98,1.09), 1 minor allele (adjusted OR:1.01, CI:0.97,1.05), 2 minor alleles (adjusted OR:0.91, CI:0.84,0.98). Similarly, vitamin D deficiency significantly increased the risk of transitioning to SLE in those with two minor alleles at rs4809959 (adjusted OR:4.90, CI: 1.33,18.04). Conclusions Vitamin D status and CYP24A1 may have a combined role in the transition to SLE in individuals at increased genetic risk for SLE.

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Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis

Mao

Huang

2013

Rheumatol Int

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Association studies of vitamin D receptor (VDR) gene polymorphisms and the risk of systemic lupus erythematosus (SLE) have yielded conflicting results in different backgrounds. We aimed to evaluate the association between VDR gene polymorphisms and SLE risk. A predefined electronic databases search was performed to identify eligible studies that were related to the association of VDR gene BsmI, FokI, ApaI or TaqI polymorphism with SLE risk. Either a fixed-effects model, or in the presence of heterogeneity, a random-effects model was used to calculate the pooled odds ratios (ORs) and its corresponding 95% confidence interval (CI). A total of 11 studies with 1,621 cases and 1,883 controls were included in this meta-analysis. BsmI B allele was associated with the onset of SLE for overall populations (OR 1.726, 95% CI 1.214-2.455) and Asians (OR 1.952, 95% CI 1.135-3.355). FokI FF genotype was correlated with the susceptibility of SLE for Asians (OR 1.469, 95% CI 1.005-2.148). FokI T/C and TaqI polymorphisms were not associated with SLE risk for Caucasians. There was no significant association between ApaI polymorphism and SLE risk for overall populations, Asians and Caucasians. No evidence of publication bias was observed. In conclusion, BsmI B allele may be a risk factor for SLE onset among overall populations and Asians, and FokI FF genotype is a risk factor for SLE susceptibility in Asians. However, more studies should be performed in the future.

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Vitamin D receptor gene BsmIpolymorphisms in Thai patients with systemic lupus erythematosus

Cited by 40 publications

References 20 publications

Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus

Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis

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