Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

Barbosa, Mariane Carolina Faria; Lima, Daniela Coêlho de; Reis, Caio Luiz Bitencourt; Reis, A.L.M.; Rigo, Darlan; Silva, Léa Assed Bezerra da; Storrer, Carmen Lúcia Mueller; Küchler, Érika Calvano; Oliveira, Daniela Silva Barroso de

doi:10.1111/ipd.12631

Cited by 15 publications

(26 citation statements)

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“…Dental caries was accessed by ICDAS (International Caries Detection and Assessment System) according to Shoaib et al (20). ICDAS was categorized as a dichotomic variable in two different cut-offs: Healthy (ICDAS 0 ) vs. Caries (ICDAS 1−6 ); or non-cavitated lesion (ICDAS 1−2 ) vs. cavitated caries lesion (ICDAS 3−6 ), as previously described (21).…”

Section: Methodsmentioning

confidence: 99%

Study of Dental Caries and PTH Gene

et al. 2021

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Parathyroid hormone (PTH) is essential for calcium and phosphate homeostasis in odontogenesis-related cells. Therefore, the present study aimed to investigate the association between single nucleotide polymorphisms in the gene encoding PTH, and dental caries in Brazilian children. Three hundred and fifty-three children (170 boys and 183 girls, age ranging from 8 to 11 years old) were included in this study. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used for diagnosis of dental caries. Visible biofilm was also evaluated during the clinical examination. Genomic DNA was extracted from saliva for real-time PCR to evaluate the single nucleotide polymorphisms rs6256, rs307247 and rs694 in PTH gene. Dental caries was classified in ICDAS0 vs. ICDAS1−6 or ICDAS1−2 vs. ICDAS3−6. Chi-square test, binary logistic regression adjusted by biofilm and haplotype analyses were performed (p < 0.05). Biofilm was associated with dental caries (p < 0.05). There were no associations between dental caries and rs6256, rs307247, rs694 in none of the analyses performed (p > 0.05). In conclusion, the present study supports that the single nucleotide polymorphisms rs6256, rs307247, and rs694 in the PTH-encoding gene are not associated with dental caries in Brazilian children.

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Section: Methodsmentioning

confidence: 99%

Study of Dental Caries and PTH Gene

et al. 2021

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“…It is estimated that there are even over 23,000 VDR binding sites in the human genome, and a large proportion of them are specific to a cell type [ 41 ]. In humans, the gene encoding the vitamin D receptor is located on chromosome 12q [ 43 ].…”

Section: Briefly About Vitamin Dmentioning

confidence: 99%

“…The VDRE sequence is highly variable. The role of this complex is remodeling of chromatin and communication with RNA polymerase II to the transcription start site [ 22 , 23 , 27 , 41 , 43 ].…”

Section: Briefly About Vitamin Dmentioning

confidence: 99%

“…The second one is called 1,25(OH) 2 D 3 membrane-bound rapid-response steroid-binding protein (MARRS). Both receptors reside in the membrane in lipid cave rafts ready to activate ion channels, kinases and phosphatases [ 27 , 43 , 44 , 45 , 46 ]. Vitamin D 3 activates rapid signal delivery pathways through kinases, phosphatases, or ion channels, which can lead to the alteration of gene expression using cognate promoter elements or regulation of gene expression using VDR as a substrate.…”

Section: Briefly About Vitamin Dmentioning

confidence: 99%

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Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

Gabryanczyk

Klimczak

Szymczak-Pajor

et al. 2021

IJMS

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There is mounting evidence that type 2 diabetes mellitus (T2DM) is related with increased risk for the development of cancer. Apart from shared common risk factors typical for both diseases, diabetes driven factors including hyperinsulinemia, insulin resistance, hyperglycemia and low grade chronic inflammation are of great importance. Recently, vitamin D deficiency was reported to be associated with the pathogenesis of numerous diseases, including T2DM and cancer. However, little is known whether vitamin D deficiency may be responsible for elevated cancer risk development in T2DM patients. Therefore, the aim of the current review is to identify the molecular mechanisms by which vitamin D deficiency may contribute to cancer development in T2DM patients. Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors. Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor β (TGFβ), insulin-like growth factor (IGF) and Wnt-β-Cathenin. It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Although, numerous studies revealed that adequate vitamin D concentration prevents or delays T2DM and cancer development, little is known how the vitamin affects cancer risk among T2DM patients. There is a pressing need for randomized clinical trials to clarify whether vitamin D deficiency may be a factor responsible for increased risk of cancer in T2DM patients, and whether the use of the vitamin by patients with diabetes and cancer may improve cancer prognosis and metabolic control of diabetes.

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“…Although the presence of bacteria is required to initiate this process, the progression of the disease depends on the host response, 3 which is, in part, genetically determined. To date, several case‐control studies examining the genetic background of plaque‐induced gingivitis have been published 4,5 . In addition, a genome‐wide association study found genetic variants were significantly associated with severe gingival inflammation 6 …”

Section: Introductionmentioning

confidence: 99%

Association of the CD14 ‐260C/T polymorphism with plaque‐induced gingivitis depends on the presence of Porphyromonas gingivalis

Bartošová

Linhartová

Musilová

et al. 2021

Int J Paed Dentistry

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Background Plaque‐induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll‐like receptors (TLRs) and their co‐receptor cluster of differentiation 14 (CD14). Aim This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Design A total of 590 unrelated children (307 with plaque‐induced gingivitis and 283 controls, aged 13‐15 years) were enrolled in this case‐control study. Dental plaque was processed using a ParoCheck® 20 detection kit. The CD14 ‐260C/T (rs2569190) polymorphism was determined with the PCR‐RFLP method. Results Gingivitis was detected in 64.2% of boys and 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 ‐260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05). Conclusions The CD14 ‐260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque‐induced gingivitis in Czech children.

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Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis

Cited by 15 publications

References 40 publications

Study of Dental Caries and PTH Gene

Study of Dental Caries and PTH Gene

Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

Association of the CD14 ‐260C/T polymorphism with plaque‐induced gingivitis depends on the presence of Porphyromonas gingivalis

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