Vitamin D Receptor and Interaction with DNA: From Physiology to Chronic Kidney Disease

Bover, Jordi; Ruiz, César; Pilz, Stefan; daSilva, Iara; Díaz, Montserrat; Guillén, Elena

doi:10.1007/978-3-319-32507-1_4

Cited by 6 publications

(6 citation statements)

References 222 publications

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“…For instance, Whitfield et al showed that relative transcription activities of endogenous human VDR proteins ranged from 2–100‐fold induction by hormone, with higher activity being displayed by the F of Fok I (F/f) and the L of L/S biallelic forms . Moreover, VDR activators are being developed as an improved biological profile for the therapeutic application in one of the pleiotropic functions of the natural hormone and diabetic kidney disease . Early intervention in DN patients is of great importance to prevent the development of this disease.…”

Section: Discussionmentioning

confidence: 99%

Association between the vitaminDreceptor gene polymorphisms and diabetic nephropathy risk:Ameta‐analysis

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Association between the vitaminDreceptor gene polymorphisms and diabetic nephropathy risk:Ameta‐analysis

et al. 2018

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“…24 1,25(OH) 2 D that passes into the bloodstream is also bound to DBP, binding to the VDR in several tissues, including parathyroid cells, bone, and intestine. 25,26 The VDR-1,25(OH) 2 D complex acts as heterodimer with the retinoic X receptor (RXR) to control transcriptional activity of target genes, after binding to special DNA sequences called vitamin D response elements. Circulating 1,25(OH) 2 D also exerts non-genomic effects through the binding in some tissues to membrane proteins with subsequent modification of the intra-cellular calcium flux and stimulation of tyrosine kinases (Figure 1).…”

Section: Vitamin D Physiologymentioning

confidence: 99%

“…79,80 The role of VDR and its interaction with DNA has been comprehensively reviewed recently from regular physiology to the systemic effects of CKD. 25 The combination of vitamin D and/or 1,25(OH) 2 D insufficiency and end-organ resistance to vitamin D contribute to the development of CKD-MBD. Additional mechanisms include the impairment of vitamin Ddependent osteocalcin production 81 and the altered Wnt signalling in osteoblasts and osteocytes observed in CKD, 82 which is associated with bone loss and vascular calcification.…”

Section: Vitamin D Metabolism In Chronic Kidney Diseasementioning

confidence: 99%

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Molina

Carrero

Bover

et al. 2017

J cachexia sarcopenia muscle

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The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.

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“…[17] 5. Types of vitamin D [39,40] Generally, vitamin D is divided into 3 groups (Table 2). The first group is composed of NVD, namely ergocalciferol and cholecalciferol.…”

Section: Definition Of Vitamin D Deficiency and Risk Factorsmentioning

confidence: 99%

Mini review: A reevaluation of nutritional vitamin D in the treatment of chronic kidney disease

Shen

2023

Medicine

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Chronic kidney disease-mineral and bone disorder is a syndrome of mineral and bone metabolism abnormalities caused by chronic kidney disease. Osteoporosis is a systemic metabolic bone disease characterized by low bone mass, disruption of bone microstructure, increased brittleness, and a higher propensity for fractures. Both of these conditions significantly affect bone metabolism and substantially increase the risk of fractures. Nutritional vitamin D is an essential trace element in the human body and an important fat-soluble vitamin. One crucial physiological role of nutritional vitamin D is to achieve mineral-bone metabolism balance by regulating calcium homeostasis. This review summarized the metabolism of vitamin in normal population and its specificity in chronic kidney disease. Over the years, the understanding and application of vitamin D in patients with chronic renal failure is changing. As people pay more attention to hypercalcemia, vascular calcification, osteoporosis, nutritional vitamin D has come into people’s attention again. More and more studies are discussing how to prescribe vitamin D supplementation in hemodialysis patients.

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Vitamin D Receptor and Interaction with DNA: From Physiology to Chronic Kidney Disease

Cited by 6 publications

References 222 publications

Association between the vitaminDreceptor gene polymorphisms and diabetic nephropathy risk:Ameta‐analysis

Association between the vitaminDreceptor gene polymorphisms and diabetic nephropathy risk:Ameta‐analysis

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

Mini review: A reevaluation of nutritional vitamin D in the treatment of chronic kidney disease

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