Vitamin D Receptor affects male mouse fertility via regulation of lipid metabolism and testosterone biosynthesis in testis

Lu, Hongzhao; Wang, Shanshan; Liu, Huan; Guo, Miaomiao; Bai, Hao; Zhang, Tao

doi:10.1016/j.gene.2022.146589

Cited by 12 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the enzymes involved in steroidogenesis have vitamin D response element (VDRE) in their promoters and may indeed suffer low vitamin levels. In a recent study in mice a VDR knock-out model, supposed to abolish the VDR-mediated genomic effects of vitamin D, resulted in a suppression of just 30% of circulating testosterone 50 , which is a lot milder deficit compared to our finding. However, besides genomic effects based on interaction with the nuclear receptor (VDRn), vitamin D is known to exert non-genomic effects likely dependent on another vitamin D binding molecule in plasma membranes, VDRm 51 .…”

Section: Discussioncontrasting

confidence: 56%

The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice

Jamshidian-Ghalehsefidi,

Rabiee,

Tavalaee

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Vitamin D deficiency is a global health problem and has been linked to defective spermatogenesis and male infertility. In this study, we aimed to investigate the main enzymes involved in the transsulfuration pathway of 1-carbon metabolism, and spermatogenesis function. Therefore, sixteen male C57 mice were addressed to a control (standard diet) or vitamin D deficient (VDD) diet for 14 weeks. The results show that compared to the standard diet, VDD increased final body weight and reduced sperm quality, caused damage to the testicular structure, and decreased the serum levels of testosterone. In addition, serum concentrations of homocysteine, vitamin B12, and sperm oxidative stress markers increased. In testicular tissues, the CBS and CSE protein levels were down-regulated whereas HO-1 was up-regulated at both mRNA and protein expression levels. Within a mice deprivation model, VDD deeply suppressed testosterone and impaired spermatogenesis with oxidative stress-mediated mechanisms. The effects of the deprivation appeared to be at least in part independent of genomic and receptor-mediated vitamin D actions and suggest a specific impairment of the alternative transsulfuration pathway.

show abstract

Section: Discussioncontrasting

confidence: 56%

The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice

Jamshidian-Ghalehsefidi,

Rabiee,

Tavalaee

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Protein concentrations were measured using a BCA protein assay kit (TransGen Biotech, Beijing, China). Western blot for validation of Mx was performed as previous described ( Wang et al, 2022 ). Rabbit anti-chicken Mx (Proteintech, Wuhan, China) was used as the primary antibody, and HRP conjugated goat anti-rabbit IgG (Proteintech) as the second antibody.…”

Section: Methodsmentioning

confidence: 99%

Targeted knockout of Mx in the DF-1 chicken fibroblast cell line impairs immune response against Newcastle disease virus

et al. 2023

Self Cite

View full text Add to dashboard Cite

“…Vit-D supplementation is also proven to boost testosterone synthesis in men. Vit-D receptors were found in testicular tissue, especially Leydig cells, where the vitamin is locally activated [ 95 ] and stimulates the synthesis of testosterone [ 96 , 97 ]. Men with Vit-D deficiency and insufficiency display reduced levels of serum testosterone and lower testosterone-to-luteinizing hormone ratio, indicating that sufficient exposure to vitamin D is required to sustain the testicular synthesis of testosterone [ 98 ].…”

Section: Preventing Sarcopenia: a Therapeutic Target In Primary And S...mentioning

confidence: 99%

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco,

Disoteo,

De Tullio

et al. 2023

Nutrients

View full text Add to dashboard Cite

Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.

show abstract

Vitamin D Receptor affects male mouse fertility via regulation of lipid metabolism and testosterone biosynthesis in testis

Cited by 12 publications

References 38 publications

The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice

The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice

Targeted knockout of Mx in the DF-1 chicken fibroblast cell line impairs immune response against Newcastle disease virus

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Contact Info

Product

Resources

About