Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin–angiotensin inhibition

Eltablawy, Nashwa; Ashour, Hend; Rashed, Laila Ahmed; Hamza, Wael Mostafa

doi:10.1080/13813455.2018.1423624

Cited by 17 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the RCT of Liyanage et al [100], patients received intramuscular administration of 50,000 IU (0.25 mL) of vitamin D 3 monthly for 6 months; the mean reduction of UACR was 51.8 mg/g (95% CI, −66.1–−37.5, p ≤ 0.001) in the treatment group, 22.4 mg/g (95% CI; −45.7–0.8, p = 0.06) in the control group and this difference was statistically significant ( p = 0.001); a significant inverse correlation was observed between vitamin D values and percentage change in plasma renin levels ( r = −0.66, p < 0.01) and percentage change in UA levels ( r = −0.47, p < 0.01). Another relevant result was the mean reduction in plasma renin in the treatment group, attested to −5.85 pg/mL (95% CI; −6.7–−4.6, p < 0.001), (suggesting another possible renoprotective effect of vitamin D: this outcome has been previously reported in animal studies [101] (Table 4).…”

Section: Vitamin D and Diabetes In Kidney Diseasessupporting

confidence: 63%

Role of Vitamin D Status in Diabetic Patients with Renal Disease

et al. 2019

View full text Add to dashboard Cite

Diabetes mellitus (DM) poses a major public health problem worldwide, with ever-increasing incidence and prevalence in recent years. The Institute for Alternative Futures (IAF) expects that the total number of people with type 1 and type 2 DM in the United States will increase by 54%, from 19,629,000 to 54,913,000 people, between 2015 and 2030. Diabetic Nephropathy (DN) affects about one-third of patients with DM and currently ranks as the first cause of end-stage kidney disease in the Western world. The complexity of interactions of Vitamin D is directly related with progressive long-term changes implicated in the worsening of renal function. These changes result in a dysregulation of the vitamin D-dependent pathways. Various studies demonstrated a pivotal role of Vitamin D supplementation in regression of albuminuria and glomerulosclerosis, contrasting the increase of glomerular basement membrane thickening and podocyte effacement, with better renal and cardiovascular outcomes. The homeostasis and regulation of the nephron’s function are absolutely dependent from the cross-talk between endothelium and podocytes. Even if growing evidence proves that vitamin D may have antiproteinuric, anti-inflammatory and renoprotective effects in patients with DN, it is still worth investigating these aspects with both more in vitro studies and randomized controlled trials in larger patient series and with adequate follow-up to confirm the effects of long-term vitamin D analogue supplementation in DN and to evaluate the effectiveness of this therapy and the appropriate dosage.

show abstract

Section: Vitamin D and Diabetes In Kidney Diseasessupporting

confidence: 63%

Role of Vitamin D Status in Diabetic Patients with Renal Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Fourth, sKlotho level is modulated by many factors including age, oxidative stress, and inflammation (Inci et al, 2016;Ruiz-Andres et al, 2016). Furthermore, sKlotho level is influenced by commonly used agents in CKD, such as phosphate binders, active vitamin D, and renin-angiotensin system inhibitors (Forster et al, 2011;Lin et al, 2014;Inci et al, 2016;Eltablawy et al, 2018;Golmohamadi et al, 2018). Hence, sKlotho level may change over time, and a single measurement at baseline in these studies may not necessarily reflect actual levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Soluble Klotho and Vascular Calcification in Chronic Kidney Disease: A Meta-Analysis and Systematic Review

Liu

Yin

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

Background: The correlation between soluble Klotho (sKlotho) level and vascular calcification (VC) in patients with chronic kidney disease (CKD) remains controversial. Using meta-analysis, we aimed to address this controversy and assess the feasibility of applying sKlotho as a biomarker for VC.Methods: Medical electronic databases were thoroughly searched for eligible publications on the association between sKlotho level and VC in CKD patients. Effectors, including correlation coefficients (r), odds ratios (ORs), hazard ratio (HR) or β-values, and 95% confidence intervals (CIs) were extracted and combined according to study design or effector calculation method. Pooled effectors were generated using both random-effects models and fixed-effects models according to I2-value. Origin of heterogeneity was explored by sensitivity analysis and subgroup analysis.Results: Ten studies with 1,204 participants from a total of 1,199 publications were eligible and included in this meta-analysis. The combined correlation coefficient (r) was [−0.33 (−0.62, −0.04)] with significant heterogeneity (I2 = 89%, p < 0.001) based on Spearman correlation analysis, and this significant association was also demonstrated in subgroups. There was no evidence of publication bias. The combined OR was [3.27 (1.70, 6.30)] with no evidence of heterogeneity (I2 = 0%, p = 0.48) when sKlotho was treated as a categorical variable or [1.05 (1.01, 1.09)] with moderate heterogeneity (I2 = 63%, p = 0.10) when sKlotho was treated as a continuous variable based on multivariate logistic regression. No significant association was observed and the pooled OR was [0.29 (0.01, 11.15)] with high heterogeneity (I2 = 96%, p < 0.001) according to multivariate linear regression analysis. There was an inverse association between sKlotho and parathyroid hormone levels. The combined coefficient (r) was [−0.20 (−0.40, −0.01)] with significant heterogeneity (I2 = 86%, p < 0.001), and without obvious publication bias. No significant association was found between sKlotho and calcium or phosphate levels.Conclusion: There exists a significant association between decreased sKlotho level and increased risk of VC in CKD patients. This raises the possibility of applying sKlotho as a biomarker for VC in CKD populations. Large, prospective, well-designed studies or interventional clinical trials are required to validate our findings.

show abstract

“…Ayrıca, D Vitamini renin-anjiyotensin-aldosteron sisteminin (RAAS) aktivitesini düzenler. Aktive olmuş RAAS ve inflamasyon AF ile sonuçlanabilecek oksidatif stres ve enflamasyona yol açabilir (22,23). Yukarıda bahsettiğimiz her iki mekanizmada atriyal fibrilasyonun (AF) patofizyolojisinde rol oynar.…”

Section: Discussionunclassified

Izole Off-Pump Koroner Arter Bypass Sonrasi Yeni Baslangicli Atrial Fibrilasyon Gelisiminde Preoperatif D Vitaminin Etkisi var midir?

2020

GMJ

View full text Add to dashboard Cite

Giriş: Çalışmamızın amacı izole off-pump koroner arter bypass yapılan hastalarda preoperatif ölçülen D vitamini düzeyi ile postoperatif AF gelişimi ve erken dönem istenmeyen olaylar ile D vitamini ilişkinin olup olmadığının ortaya konulmasıdır. Method: Hastanemizde off-pump koroner bypass yapılan ardışık 55 hasta, çalışmaya dahil edildi. Hastalar operasyondan sonraki ilk beş gün içerisinde herhangi bir zamanda AF gelişmeyen hastalar grup 1 (n=44) ve AF gelişen hastalar grup 2 (n = 11) olarak iki gruba ayrıldı. Preoperatif kan D vitamini düzeyleri ile postoperatif AF ve postoperatif komplikasyonlar açısından iki grup incelendi. Sonuçlar: İki grup arasında preoperatif D vitamini değerleri açısından iki grup arasında anlamlı fark yoktu (P=0.850). Postoperatif komplikasyonlar açısından ise solunum problemi, plevral effüzyon, yara yeri enfeksiyonu, stroke, böbrek yetmezliği nedeniyle diyaliz ve mortalite arasında da iki grup arasında fark saptanmadı (p>0.05). Ayrıca D vitamini ile postoperatif komplikasyonlar arasında da fark korelasyon saptanmadı. Tartışma: Litaratürde ilk defa çalışmamızda, preoperatif D vitamin düzeyleri ile off-pump koroner bypass sonrası AF gelişimi arasında ilişkinin olup olmadığı incelendi. Yaklaşık 1 yıllık ve tüm mevsimleri içeren çalışmamızda D vitamini ile postoperatif AF arasında anlamlı bir ilişki saptanmadı.

show abstract

Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin–angiotensin inhibition

Abstract: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.

Cited by 17 publications

References 38 publications

Role of Vitamin D Status in Diabetic Patients with Renal Disease

Role of Vitamin D Status in Diabetic Patients with Renal Disease

Correlation Between Soluble Klotho and Vascular Calcification in Chronic Kidney Disease: A Meta-Analysis and Systematic Review

Izole Off-Pump Koroner Arter Bypass Sonrasi Yeni Baslangicli Atrial Fibrilasyon Gelisiminde Preoperatif D Vitaminin Etkisi var midir?

Contact Info

Product

Resources

About