Vitamin D, parathyroid hormone, serum calcium and phosphorus in patients with schizophrenia and major depression

Jamilian, Hamidreza; Bagherzadeh, Kamran; Nazeri, Zeinab; Hassanijirdehi, Marzieh

doi:10.3109/13651501.2012.667111

Cited by 51 publications

(23 citation statements)

References 21 publications

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“…This first finding is in contrast to earlier case-control studies including patients with established psychotic disorders (Rey-Sanchez et al, 2009;Partti et al, 2010;Itzhaky et al, 2012;Jamilian et al, 2013). These previous studies however have methodological limitations, including lack of adjustment for ethnicity (Rey-Sanchez et al, 2009;Partti et al, 2010;Doknic et al, 2011;Jamilian et al, 2013), comparison between hospitalized patients and health care workers (Itzhaky et al, 2012) or hospitalized patients and healthy controls recruited by advertisements without control for place of residence (Crews et al, 2013).…”

Section: Discussioncontrasting

confidence: 52%

“…These previous studies however have methodological limitations, including lack of adjustment for ethnicity (Rey-Sanchez et al, 2009;Partti et al, 2010;Doknic et al, 2011;Jamilian et al, 2013), comparison between hospitalized patients and health care workers (Itzhaky et al, 2012) or hospitalized patients and healthy controls recruited by advertisements without control for place of residence (Crews et al, 2013). The healthy controls in the current study were randomly recruited from the same catchment area as the study patients and matched both for ethnicity and other important confounding variables such as gender and age.…”

Section: Discussionmentioning

confidence: 98%

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Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 98%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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“…In fact, Lebanon is located at appropriate latitudes (33° 35'N) [38] for the synthesis of vitamin D [39] and thus, higher levels of total vitamin D would be expected [39]. Furthermore, our results indicated that patients with schizophrenia, as well as the healthy ones, had a vitamin D deficiency, similar to previous studies [2,4,36,37,40,41]. Other studies conducted in Lebanon had shown a hypovitaminosis D in the healthy population [35,[42][43][44][45].…”

Section: Discussionsupporting

confidence: 80%

“…A meta-analysis, including 19 studies (2804 participants), showed a strong association between vitamin D deficiency and schizophrenia [2], with 65% of them being vitamin D deficient [2]. Other studies [6,36,37] showed that adults with schizophrenia have significantly lower serum concentrations of vitamin D as compared with healthy controls. It was expected that vitamin D levels in the Lebanese population would be higher due to the sunny climate.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

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Objectives: To compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the correlation between severe vitamin D deficiency and the severity of schizophrenia symptoms and to evaluate the potential factors influencing this status. Methods:A case-control study, conducted between March and July 2016, recruited 100 patients with schizophrenia and 100 controls with no known psychiatric disorders and matched for age and sex.Results: Schizophrenic patients had a more severe vitamin D deficiency compared to healthy controls (9% vs. 3%). Vitamin D insufficiency was found in 28% of schizophrenic patients compared to 37% in healthy controls (p=0.053). BCRS and MRSS scales were significantly associated with a more severe vitamin D deficiency (p=0.006). We couldn't detect any association between the total PANSS score and its three subscales with vitamin D deficiency (p>0.05). Lebanon has a high prevalence of 25(OH)-D deficiency in adults and older adults [23,24] however, data regarding vitamin D levels in psychiatric patients is still lacking. Therefore, the primary objective of this study was to compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the

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“…A number of epidemiological studies have found associations between serum 25(OH)D concentrations and depression, independent of lifestyle and health factors (Ganji et al, 5 Wendy H. Oddy 2010; Hoang et al, 2011;Jamilian et al, 2013;Kjaergaard et al, 2011;Lee et al, 2011;Milaneschi et al, 2010;Tolppanen et al, 2012). However, others have shown no association, including a large population-based study in the United States (Nanri et al, 2009;Pan et al, 2009;Zhao et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

Low vitamin D levels are associated with symptoms of depression in young adult males

Black

Jacoby

Allen

et al. 2013

Aust N Z J Psychiatry

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Objective Results from epidemiological studies examining associations between serum 25(OH)D concentrations and depression are equivocal. We investigated the relationship between serum 25(OH)D concentrations and symptoms of depression, anxiety and stress in a population‐based cohort of young adults. Methods The Western Australian Pregnancy Cohort (Raine) Study is a prospective, longitudinal study from birth to adulthood. Symptoms of depression, anxiety and stress were assessed at the 20 year follow‐up using the 21‐item Depression Anxiety Stress Scales (DASS‐21). Associations between serum 25(OH)D concentrations and DASS‐21 scores were explored using multiple linear regression, adjusting for potential confounders (n = 693). Results In males, low serum 25(OH)D concentrations were significantly associated with symptoms of depression (β = −0.20, p < 0.001), anxiety (β = −0.12, p = 0.041) and stress (β = −0.13, p = 0.022). No significant associations were seen in females. Conclusions We found that low serum 25(OH)D concentrations were associated with symptoms of depression, anxiety and stress in males. Further studies are warranted to elucidate the relationship between vitamin D status and these mental health symptoms in young adults. This work was supported by the National Health and Medical Research Council of Australia Project #1022134 (2012–2014).

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Vitamin D, parathyroid hormone, serum calcium and phosphorus in patients with schizophrenia and major depression

Cited by 51 publications

References 21 publications

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Low vitamin D levels are associated with symptoms of depression in young adult males

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