Vitamin D, parathyroid hormone and metabolic syndrome – the PORMETS study

Raposo, Luís; Martins, Sandra; Ferreira, Daniela; Guimarães, João Tiago; Santos, Ana Cristina

doi:10.1186/s12902-017-0221-3

Cited by 37 publications

(54 citation statements)

References 36 publications

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“…A research study had presented that the levels of serum 25(OH)D have a positive relationship with the levels of LDL-C, TC, and HDL-C, and negative association between the levels of 25(OH)D and serum levels of TG. However, the outcomes obtained from another study were completely different and suggested a negative association between levels of TG, TC, and LDL-C, while the relationship between HDL-C and 25(OH)D was found positive and significant [13].…”

Section: Literature Reviewmentioning

confidence: 81%

Effect of Vitamin D deficiency on Lipid Profile

Bashir¹

2019

AJLM

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The purpose of this study is to investigate the effect of vitamin D deficiency on lipid parameters; cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL). Serum level of vitamin D and the lipid parameters were determined in 127 subjects attending private community lab in eastern Amman province, using commercially available kits. Deficiency and insufficiency of vitamin D were 36.2%, 29.9%, respectively. Serum level of cholesterol, triglycerides, and LDL in deficient and insufficient vitamin D subjects were significantly increased, while HDL level was decreased, P-value <0.05. Serum levels of lipid profile and vitamin D in each of the control, insufficient , and deficient groups were all normally distributed due to the fact that P-value is greater than 0.05. Interval plot analysis and One-way ANOVA analysis revealed a significant effect of vitamin D insufficiency or deficiency on serum level of cholesterol, triglycerides, and LDL and increases the levels more than the double. Two samples T-test for every lipid parameter analysis related to subjects in the sufficient, insufficient and deficient vitamin D groups confirm our hypothesis on the effect of vitamin D deficiency on increasing the levels of cholesterol, triglycerides, and LDL and decreasing the level of HDL.

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Section: Literature Reviewmentioning

confidence: 81%

Effect of Vitamin D deficiency on Lipid Profile

Bashir¹

2019

AJLM

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“…Vitamin D deficiency has been linked to a variety of health problems from bone diseases to chronic diseases, such as MetS [ 42]. In the present longitudinal study, the association between vitamin D status and MetS development after 12 years follow up of Iranian adults was not established.…”

Section: Discussionmentioning

confidence: 55%

Association between vitamin D status and metabolic syndrome in a longitudinal study of Iranian adults

Khosravi-Boroujeni

Sarrafzadegan²,

Sadeghi

et al. 2019

Preprint

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Background In recent years, hypovitaminosis D has been linked to many chronic diseases, including metabolic syndrome (MetS). However, there are considerable discrepancies in the study findings. Therefore, the present study investigated the association between vitamin D status and MetS in a cohort of Iranian adults followed from 2001 to 2013. Method This study was designed using the data from Isfahan cohort study which is an ongoing cohort of Iranian adults. For this study, 170 cases with MetS were selected from those who were free of MetS in 2001 but developed the condition in 2013. Controls (n=200) were selected from those who were free of MetS throughout the study period. Various biochemical parameters, including serum vitamin D concentrations, and socio-demographic information were assessed in 2001, 2007 and 2013. Generalized Estimating Equations was used to analyse the longitudinal association between vitamin D status and MetS. Results The subjects with MetS had higher levels of serum vitamin D [25(OH)D], total cholesterol, triglyceride, body mass index, waist circumference, systolic and diastolic blood pressure than that in the control subjects in 2001, while they had lower physical activity levels. A family history of hyperlipidemia was also more prevalent in the subjects with MetS. This study did not find any association between MetS and serum vitamin D status after controlling for potential confounders. Conclusion In spite of the high prevalence of vitamin D deficiency and MetS among studied population, this study failed to show any association between vitamin D status and MetS and/or its components. Randomized controlled trials are warranted to investigate the potential association more meticulously.

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“…The primary outcome of analyses was the metabolic syndrome (MetS) severity score, which was calculated for participants using equations based on waist circumference, serum high-density lipoprotein, triglycerides, systolic blood pressure (not diastolic), and fasting blood glucose, as described previously [17]. Serum parathyroid hormone concentration was an independent variable; the normal serum PTH range is 15-65 pg/ml [11], thus elevated PTH was defined as > 65 pg/ml. Potentially moderating variables included daily total nutrient intake (energy, protein, total sugars, total fat, total saturated fatty acids, and cholesterol), daily mineral intake (Kalzium, magnesium, and phosphorus), daily supplements (vitamin A, vitamin D), caffeine consumption, and behavior and lifestyle factors (physical activity and alcohol consumption).…”

Section: Main Outcomesmentioning

confidence: 99%

“…In addition, 25-hydroxyvitamin D, or 25(OH)D, is an indicator of vitamin D status that is associated with Kalzium homeostasis, insulin resistance, obesity, dyslipidemia, and bone metabolism [10]. It has also been shown to have a fairly consistent inverse relationship with MetS [5,11], although the association between MetS and low serum vitamin D varies between ethnic groups [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Moderators of the Association Between Serum Parathyroid Hormone and Metabolic Syndrome in Participants with Elevated Parathyroid Hormone: NHANES 2003–2006

2020

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This cross-sectional study extracted data of 392 NHANES participants with elevated serum parathyroid hormone (PTH) concentrations from 2 cycles of the US National Health and Nutrition Examination Survey (NHANES) 2003–2006 and evaluated the association between serum (PTH) concentration and metabolic syndrome (MetS) to identify dietary and lifestyle factors that may modify that association. The primary outcome was MetS severity scores. Results of univariate linear regression analyses revealed that serum PTH concentrations correlated positively and significantly with MetS severity scores (β=0.399, p=0.030). After adjusting for gender, age, race, and alcohol consumption, results of multivariate analysis revealed that increased serum PTH concentration correlated significantly with higher MetS severity scores (β=0.413, p=0.045) in participants with moderate physical activity over the past 30 days. Serum PTH concentration also correlated significantly with higher MetS severity scores in participants with serum 25-hydroxyvitamin D deficiency (β=0.456 and p=0.014), those without vitamin D supplementation (β=0.524, p=0.028) and with higher protein intake (β=0.586 and p=0.030). In conclusion, increased serum PTH concentration is associated with higher MetS severity scores in participants with elevated serum PTH at baseline. The association between PTH concentration and MetS severity is moderated by participants’ physical activity levels, status of serum vitamin D, vitamin D supplementation, and daily protein intake.

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Vitamin D, parathyroid hormone and metabolic syndrome – the PORMETS study

Cited by 37 publications

References 36 publications

Effect of Vitamin D deficiency on Lipid Profile

Effect of Vitamin D deficiency on Lipid Profile

Association between vitamin D status and metabolic syndrome in a longitudinal study of Iranian adults

Moderators of the Association Between Serum Parathyroid Hormone and Metabolic Syndrome in Participants with Elevated Parathyroid Hormone: NHANES 2003–2006

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