Vitamin D, oxidative stress, and diabetes: crossroads for new therapeutic approaches

Nikooyeh, Bahareh; Anari, Razieh

doi:10.1016/b978-0-12-815776-3.00039-5

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…However, pathological increment of OS during pregnancy could have a role in development of adverse pregnancy outcomes through damaging susceptible placenta [19,20]. On the other hand, some studies have revealed antioxidative properties of vitamin D [21][22][23] which might be associated with certain metabolic variables, notably blood glucose and lipids [24]. However, these effects of vitamin D during pregnancy still need further elucidation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Motamed

Nikooyeh

Kashanian

et al. 2020

BMC Pregnancy Childbirth

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Background Vitamin D deficiency during pregnancy is common and is likely to be associated with metabolic complications in the mother. The aim of this study was to assess the efficacy of two doses of vitamin D supplementation during pregnancy on maternal and cord blood vitamin D status and metabolic and oxidative stress biomarkers. Methods The eligible pregnant women (n = 84) invited to participate in the study and randomly allocated to one of the two supplementation groups (1000 IU/d vitamin D and 2000 IU/d). Biochemical assessments of mothers including serum concentrations of 25(OH)D, calcium, phosphate, iPTH, fasting serum sugar (FBS), insulin, triglyceride, total cholesterol, LDL-C, HDL-C, malondialdehyde (MDA) and total antioxidant capacity (TAC) were done at the beginning and 34 weeks of gestation. Cord blood serum concentrations of 25(OH)D, iPTH, MDA and TAC were assessed at delivery as well. To determine the effects of vitamin D supplementation on metabolic markers 1-factor repeated-measures analysis of variance (ANOVA) was used. Between groups comparisons was done by using Independent-samples Student’s t-test or Mann-Whitney test. P < 0.05 was considered as significant. Results Supplementation with 1000 IU/d and 2000 IU/d vitamin D resulted in significant changes in vitamin D status over pregnancy (24.01 ± 21.7, P < 0.001 in 1000 IU/d group and 46.7 ± 30.6 nmol/L, P < 0.001 in 2000 IU/d group). Daily intake of 2000 compared with 1000 IU/d tended to increase the serum concentration of HDL-C (10 ± 8.37, P < 0.001 in 1000 IU/d group and 9.52 ± 11.39 mg/dL, P < 0.001 in 2000 IU/d group). A significant decrement in serum concentration of iPTH observed in both groups (− 4.18 ± 7.5, P = 0.002 in 1000 IU/d group and − 8.36 ± 14.17, P = 0.002 in 2000 IU/d group). Conclusions Supplementation with 2000 IU/d vitamin D as compared with 1000 IU/d, is more effective in promoting vitamin D status and HDL-C serum concentration and in decreasing iPTH over pregnancy. Trial registration This trial is registered at clinicaltrials.gov (NCT03308487). Registered 12 October 2017 ‘retrospectively registered’.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Motamed

Nikooyeh

Kashanian

et al. 2020

BMC Pregnancy Childbirth

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“…New studies indicate a wide spectrum of activities for vitamin D in CNS including energy hemostasis through central renin-angiotensin system (RAS) [24], protective effect against autoimmunity through attenuation of micoglia activation via neuronspecific signaling [25] and overall mental health in both children and adults [26,27]. The anti-inflammatory and anti-oxidant properties of vitamin D have already been documented in other clinical settings [28][29][30][31], but assessment of these effects in relation to depression needs more studies. We have recently reported the effect of vitamin D supplementation on depression and certain neurotransmitters [32].…”

Section: Background and Objectivesmentioning

confidence: 99%

Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

et al. 2022

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Background Both augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on serum 25(OH)D concentration, depression severity and some pro-inflammatory biomarkers in patients with mild to moderate depression. Methods An 8-week double-blind randomized clinical trial (RCT) was performed on 56 (18–60 yrs) patients with mild to moderate depression, randomly assigned to intervention (50,000 IU cholecalciferol 2wks−1) and control (placebo) groups. Serum 25(OH)D, intact parathyroid hormone (iPTH), interlukin (IL)-1β, IL-6, high-sensitivity C-reactive protein (hs-CRP) and depression severity (Beck Depression Inventory-II) (BDI-II)) were initially and finally assessed. Results At the end point, statistically significant changes were observed only in intervention group as compared with controls including increased 25(OH)D concentration (+ 40.83 ± 28.57 vs. + 5.14 ± 23.44 nmol L−1, P < 0.001) and decreased depression severity (-11.75 ± 6.40 vs. -3.61 ± 10.40, P = 0.003). No significant within- or between group differences were observed in serum IL-1β, IL-6 and hs-CRP concentrations. Conclusion Increased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks−1) resulted in a significant decrease in BDI-II scores in patients with mild to moderate depression. However, this effect was independent of the serum concentrations of the studied inflammatory biomarkers. Trial registration The clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (date of registration: 17/09/2018, registration number: IRCT20170926036425N1) and ClinicalTrials.gov (date of registration: 04/12/2018, registration number: NCT03766074)

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The Importance of Inflammatory State in Vitamin Supplementation Studies

Nikooyeh

Neyestani

2022

Biomarkers in Disease: Methods, Discoveries and Applications

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Vitamin D, oxidative stress, and diabetes: crossroads for new therapeutic approaches

Cited by 6 publications

References 51 publications

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

The Importance of Inflammatory State in Vitamin Supplementation Studies

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