Vitamin D metabolism in the premature newborn: A randomized trial

Hanson, Corrine; Jones, Glenville; Lyden, Elizabeth; Kaufmann, Martin; Armas, Laura A.G.; Anderson‐Berry, Ann

doi:10.1016/j.clnu.2015.07.023

Cited by 25 publications

(27 citation statements)

References 37 publications

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“…In addition, the 25(OH)D radioimmunoassay used did not measure 25(OH)D epimers. Vitamin D metabolite epimers historically were considered to be inert, but recent data demonstrates that they may have some amount of bioactivity and are present in preterm infant blood [15, 16]. Therefore, further investigation of vitamin D function may require measurement of epimers to be included in the equations.…”

Section: Discussionmentioning

confidence: 99%

Functional indicators of vitamin D adequacy for very low birth weight infants

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Functional indicators of vitamin D adequacy for very low birth weight infants

et al. 2018

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“…Some studies evaluated the effect of vitamin D supplementation at different doses in preterm infants of various gestational age and birth weight [ 124 , 128 – 146 ]. Vitamin D supplementation at 400 IU/day has been generally retained safe and effective in maintaining adequate serum 25(OH)D levels in preterm infants [ 131 , 132 , 135 , 139 – 141 ]. Studies that evaluated vitamin D supplementation at 200 IU/day gave conflicting results [ 128 , 129 , 134 ].…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vierucci²,

et al. 2018

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Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.

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“…Roberta et al reported a beneficial effect with vitamin D supplementation 400 IU daily in a group of 148 preterm infants in Ireland, with the percentage of hypovitaminosis D (defined as serum 25OHD <20 ng/mL) decreasing from 78% at a median age of 18 days to 13% at a median age of 104 days [7]. A smaller study conducted by Natarajan et al also reported daily vitamin D supplementation at both 400 IU and 800 IU reduced the prevalence of VDD at 40 weeks' CGA and at 3 months' CGA in preterm infants in India, with the 800 IU arm achieving better effect (from 37% to 14% vs. 40% to 30%) [8] Similarly, a recent study by Hanson et al reported vitamin D supplementation at 400 IU and 800 IU are both effective in raising 25(OH)D concentrations, with mean serum 25(OH)D concentrations improved from 16.4ng/mL and 18.4 ng/mL to 54.1 ng/ mL and 65.7 ng/mL, respectively) in a small group of preterm neonates in America [9]. In contrast, Hitnova et al reported no significant effect of vitamin D supplementation at 1334 IU daily from day 20 onwards upon hypovitaminosis D in their cohort of preterm infants (≤32 weeks, n: 41) in Bulgaria.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status in Premature Infants at Risk of Metabolic Bone Disease of Prematurity

J¹,

Ac²,

Kelly³

2017

Matern Pediatr Nutr

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Objectives: The purpose of this study is to report the vitamin D status in a group of premature infants with increased risk of MBD and to describe the relationship between their vitamin D status and intake.Methods: Retrospective descriptive study in in a level IV neonatal intensive care unit. Results:One hundred and fifty-two subjects were included in the study. Mean gestational age was 26.8 ± 3.3 weeks and mean age was 157 ± 93 days. Mean serum 25OHD concentration was 57.8 ± 2.0 mg/mL. The prevalence of 25OHD <20 ng/mL and 25OHD >100 ng/mL was 5.9% (n=9) and 8.6% (n=13), respectively. No association between 25OHD level and vitamin D intake with respect to total daily dose (p=0.43) or total daily dose based on body weight (p=0.812) was found. Younger gestational age and younger chronological age were associated with wider range of 25OHD levels. Conclusions:Both suboptimal and elevated 25OHD concentrations are found with our current protocol for supplementation. Vitamin D status in premature infants does not correlate with their vitamin D intake, but younger gestational age and chronological age are both associated with more diverse range of 25OHD.

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Vitamin D metabolism in the premature newborn: A randomized trial

Cited by 25 publications

References 37 publications

Functional indicators of vitamin D adequacy for very low birth weight infants

Functional indicators of vitamin D adequacy for very low birth weight infants

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Vitamin D Status in Premature Infants at Risk of Metabolic Bone Disease of Prematurity

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