Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis

Hillman, Laura S.; Cassidy, James T.; Johnson, Linda Y; Lee, Ding; Allen, Susan H.

doi:10.1016/s0022-3476(05)83179-8

Cited by 66 publications

(55 citation statements)

References 35 publications

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“…These observations indicate that there is a reduction in bone turnover early in the disease course. The results are consistent with the results from studies of bone turnover in patients with a longer disease duration (31)(32)(33). Although corticosteroids are known to reduce bone turnover in children (18), the proportion of our patients who were currently receiving oral corticosteroids fell from 19% at baseline to 12% at followup, and cannot be the only explanation for the reduction in bone turnover during the observation period.…”

Section: Discussionsupporting

confidence: 90%

A two‐year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis

Lien¹,

Selvaag²,

Flatø³

et al. 2005

Arthritis & Rheumatism

103

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Objective. To explore early changes and predictors of bone mass in children with juvenile idiopathic arthritis (JIA) in order to identify patients who will develop bone mass reductions.Methods. We conducted a prospective cohort study of 108 children with early JIA (ages 6-18 years; mean disease duration 19.3 months) who were individually matched with 108 healthy children for age, sex, race, and county of residence. Bone mass and changes in total body, spine, femur, and forearm bone mineral density and bone mineral content (BMC), body composition, growth, and biochemical parameters of bone turnover were examined at baseline and at followup a mean of 24 months later. Low bone mass was defined as a Z score >1 SD below the reference population.Results. Of the 200 children evaluated at followup, the 100 healthy children had greater gains in total body BMC (P ‫؍‬ 0.035), distal radius BMC (P < 0.001), and total body lean mass (P < 0.001) than did the 100 JIA patients. Low or very low total body BMC was observed in 24% of the patients and 12% of the healthy children. Bone formation, bone resorption, and weight-bearing activities were reduced in the patients compared with the healthy children. Multiple regression analysis showed that in patients with JIA, serum bonespecific alkaline phosphatase, serum C-telopeptide of type I collagen, and weight-bearing activities were independent predictors of changes in total body BMC. Total body BMC was lower in patients with polyarticular onset than in those with oligoarticular disease onset.Conclusion. Patients with JIA have moderate reductions in bone mass gains, bone turnover, and total body lean mass early in the disease course.

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Section: Discussionsupporting

confidence: 90%

A two‐year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis

Lien¹,

Selvaag²,

Flatø³

et al. 2005

Arthritis & Rheumatism

103

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“…Generally young girls consume only a little vitamin D (Andersen et al, 1995b;Samuelsson et al, 1996), although in Iceland the situation is much better (Kristiansson et al, 1998). In our study the mean S-25(OH)D concentration was lower (33.9 nmolal) than those observed in earlier studies in wintertime (Savolainen et al, 1980;Ko Ènig et al, 1993;Hillman et al, 1994;Moulas et al, 1997) (Table 4). However, in the studies of the 1980s S-25(OH)D was assayed by a different technique, and it is thus dif®cult to compare those results with ours.…”

Section: Hypovitaminosis D and Dietary Intakes In Girls M Lehtonen-vecontrasting

confidence: 74%

Vitamin D intake is low and hypovitaminosis D common in healthy 9− to 15-year-old Finnish girls

Lehtonen-Veromaa

Möttönen

Irjala³

et al. 1999

Eur J Clin Nutr

188

131

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Objectives: To study the prevalence of hypovitaminosis D, the effect of vitamin D supplementation on serum 25-hydroxyvitamin D [S-25(OH)D], and the intakes of vitamin D and calcium in Finnish 9-to 15-year-old athletic and nonathletic girls. Design: 1-year follow-up study (February 1997-March 1998 with three months of vitamin D supplementation (10 mgad) from October to January. Setting: Turku University Central Hospital, Finland. Subjects: 191 female volunteers aged 9 ± 15 y (131 athletes and 60 controls). Methods: Vitamin D and calcium intakes were estimated by a four-day food recording and a semi-quantitative food frequency questionnaire (FFQ). S-25(OH)D was followed by radioimmunoassay (RIA). Results: At baseline the mean S-25(OH)D concentration was 33.9 nmolal among all girls. In winter severe hypovitaminosis D (S-25(OH)D`20 nmolal) occurred in 13.4% of the participants and in 67.7% S-25(OH)D was below 37.5 nmolal. By the next summer the mean S-25(OH)D concentration was 62.9 nmolal and in 1.6% of the subjects it was below 37.5 nmolal. The prevalence of severe hypovitaminosis D was not signi®cantly reduced by three months of vitamin D (10 mgad) supplementation. At baseline, the mean intake of vitamin D was 2.9 mgad by food recording and 4.3 mgad by FFQ. The mean calcium intake was 1256 mgad and 1580 mgad, respectively. The intakes of vitamin D and calcium remained unchanged during the follow-up period. The athletes consumed more calcium than nonathletic controls, whereas the intake of vitamin D was quite similar among both groups. The vitamin D intake by FFQ correlated with the S-25(OH)D concentration in wintertime (r 0.28, P`0.01). Conclusion: Hypovitaminosis D is fairly common in growing Finnish girls in the wintertime, and three months of vitamin D supplementation with 10 mgad was insuf®cient in preventing hypovitaminosis D. The daily dietary vitamin D intake was insuf®cient (`5 mgad) in the majority of participants, while the calcium intake was usually suf®cient.

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“…Mounting evidence suggests that, in addition to its well-described roles in skin, bone, and muscle physiology (30 ), the hormone 25OHD acts as an inhibitor of the inflammatory response through several pathways (31 ). Decreased 25OHD concentrations have been associated with an increased risk of developing autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes (32)(33)(34)(35). 25OHD administration has been shown to prevent the initiation and attenuate the severity of immune-mediated diseases, including type 1 diabetes (36,37 ) and animal models for multiple sclerosis (38 ).…”

Section: Discussionmentioning

confidence: 99%

Atorvastatin Increases 25-Hydroxy Vitamin D Concentrations in Patients with Polycystic Ovary Syndrome

et al. 2010

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Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis

Cited by 66 publications

References 35 publications

A two‐year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis

A two‐year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis

Vitamin D intake is low and hypovitaminosis D common in healthy 9− to 15-year-old Finnish girls

Atorvastatin Increases 25-Hydroxy Vitamin D Concentrations in Patients with Polycystic Ovary Syndrome

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