“…Further to the wide expression of vitamin D receptor (VDR) and vitamin D key metabolic enzymes, including 25-hydroxylase, 1-alpha-hydroxylase (CYP27B1) and CYP24A1 in Central Nervous System (CNS) regions, vitamin D seems to be involved in various physiological brain processes, i.e., brain development, synaptic plasticity, neurotransmission, and cell death prevention [ 25 , 41 , 42 , 43 ]. SNVs in the vitamin D pathway genes, including VDR , CYP2R1 , CYP24A1 and CYP27B1 , were associated with vitamin D serum levels [ 44 , 45 , 46 ]. Although the exact role of vitamin D in migraine remains obscure, vitamin D might be implicated via a variety of proposed mechanisms in the complex pathways involved in the pathophysiology of migraine [ 47 , 48 , 49 , 50 ].…”