2015
DOI: 10.1210/en.2014-1647
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Vitamin D Limits Chemokine Expression in Adipocytes and Macrophage Migration In Vitro and in Male Mice

Abstract: Vitamin D (VD) displays immunoregulatory effects and reduces adipocyte inflammation, which may participate to a reduction of adipose tissue macrophage infiltration in the context of obesity-associated low-grade inflammation. These observations have been described mainly in vitro, through the evaluation of a limited number of inflammatory markers. Here, we studied the effects of 1,25 dihydroxy-VD on chemokine network expression in adipocytes (by transcriptomic approach), and we confirm the physiological relevan… Show more

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Cited by 67 publications
(81 citation statements)
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“…AT represents not only the main site of vitamin D accumulation in humans, but also a main target of vitamin D action. AT-vitamin D hydroxylases are capable of locally converting this hormone in its active forms [25,26] which display autocrine and paracrine immunoregulatory actions through the specific vitamin D receptor [27,28]. It is plausible, indeed, that chronic DPP4 inhibition modulates AT inflammation and stimulates vitamin D activation/mobilization from adipocytes into the bloodstream.…”
Section: Discussionmentioning
confidence: 99%
“…AT represents not only the main site of vitamin D accumulation in humans, but also a main target of vitamin D action. AT-vitamin D hydroxylases are capable of locally converting this hormone in its active forms [25,26] which display autocrine and paracrine immunoregulatory actions through the specific vitamin D receptor [27,28]. It is plausible, indeed, that chronic DPP4 inhibition modulates AT inflammation and stimulates vitamin D activation/mobilization from adipocytes into the bloodstream.…”
Section: Discussionmentioning
confidence: 99%
“…Besides the observed effects, vitD decreases proinflammatory cytokines and chemokines in mice after an injection of lipopolysaccharide and in diet-induced obese mice, which caused a metabolic inflammation [61]. In humans, a negative association was found between serum 25(OH)-D concentration and plasma interleukin (IL)-6 and TNF-α levels in normal-weight subjects.…”
Section: Vitd and Inflammationmentioning
confidence: 93%
“…Interestingly, Zoico et al recently demonstrated that VD, similarly to 1,25(OH) 2 D, was able to blunt the lipopolysaccharide-mediated pro-inflammatory effect in human adipocytes (37) . Using a microarray approach, we recently demonstrated that 1,25(OH) 2 D was able to downregulate a large set of chemokines (80) induced by inflammatory stimulus (81) in human and murine adipocytes. This effect was accompanied by a reduction of macrophage migration mediated by an adipocyte-conditioned medium (80) .…”
Section: Regulation Of Inflammationmentioning
confidence: 99%
“…Using a microarray approach, we recently demonstrated that 1,25(OH) 2 D was able to downregulate a large set of chemokines (80) induced by inflammatory stimulus (81) in human and murine adipocytes. This effect was accompanied by a reduction of macrophage migration mediated by an adipocyte-conditioned medium (80) . These anti-inflammatory properties of 1,25(OH) 2 D have also been established in several types of immune cells found in the adipose tissue, including lymphocytes and macrophages (78) .…”
Section: Regulation Of Inflammationmentioning
confidence: 99%