Vitamin D levels in patients with Behçet’s disease: Significance and impact on disease measures

Ganeb, Sahar; Sabry, H.H.; El-Assal, Mohammed M.; Kamal, Howyda M.; Fayed, Ayser

doi:10.1016/j.ejr.2013.01.006

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…It is possible that higher levels of Vit D are immunomodulatory and downregulate inflammatory pathways commonly associated with BD and thereby are protective against disease flares. The small sample size clearly makes it difficult to demonstrate significance but our observations support the findings from other published studies [ 12 , 14 , 16 ] and suggest that serum concentrations of 25(OH)D in subjects with BD correlate inversely with disease activity.…”

Section: Discussionsupporting

confidence: 64%

“…Recent studies from Mediterranean countries and the Far East have uncovered potentially important links between Vit D and BD [ 9 – 16 , 21 – 23 ]. Interestingly, the findings indicate an inverse correlation between Vit D and BD [ 9 – 15 ] with higher levels of Vit D correlating with lower levels of disease activity [ 12 , 14 , 16 ]. It is hypothesized that low levels of Vit D suppress T-regulatory cells (T regs ) activity, cause skewing of the Th1/Th2 balance towards Th1, and impair endothelial function [ 10 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet’s Disease

Adeeb

Khan

et al. 2017

International Journal of Inflammation

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Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels <20 nmol/L were classified as deficient while levels between 20 and 40 nmol/L were classified as insufficient. Differences between groups were assessed using Mann–Whitney test and associations between cases and controls were expressed as odds ratios and 95% confidence intervals. Nineteen patients with BD were compared with 95 controls matched by age, sex, and month of blood draw. 25(OH)D levels were significantly higher in patients in BD than in matched controls (median values: 45 nmol/L versus 22 nmol/L, p < 0.005) and tended to be lower in patients with active disease than in those without (median values: 35 nmol/L (IQR: 22.75–47.25 nm/L) versus 50 nmol/L (IQR: 35–67 nmol/L), p = 0.11). Compared to controls, patients with BD were significantly less likely to have 25(OH)D deficiency or insufficiency (OR: 0.09, 95% CI: 0.03–0.28, p < 0.001). Our findings suggest a possible role for 25(OH)D in modifying the inflammatory response in BD and uncover a potential opportunity to assess whether correction of Vit D deficiency confers protective benefits.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet’s Disease

Adeeb

Khan

et al. 2017

International Journal of Inflammation

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“…BD is a systemic disorder, resulting in vasculitis with endothelial dysfunction. The diagnostic criteria include aphthous stomatitis, recurrent genital ulcerations, ocular lesions (uveitis and a retinal vasculitis) and skin lesions (erythema nodosum) or a positive pathergy test [ 19 , 28 , 29 ]. The origin of BD is not fully understood, but immunological disorders have been implicated, with T-cell mediated immunoresponse playing an important role [ 19 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ganeb et al examined 42 BD patients and 41 controls, and confirmed lower vitamin D levels in those suffering from BD. They concluded that there was no significant correlation between vitamin D serum levels and the disease duration ( p = 0.6), but reported a negative association between the vitamin D levels and Behçet’s Disease Current Activity Form (BDCAF) score [ 28 ]. Faezi et al studied a large group of 112 BD patients and 112 healthy controls and concluded that although the vitamin D serum levels were lower in the study group, the prevalence of vitamin D deficiency was more common in the control group [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, significantly increased salivary human neutrophil pepetide-1 (HNP-1) concentrations in comparison to healthy controls were observed in RAS and Behçet’s syndrome (IBD) [ 27 ]. Furthermore, several studies have shown a potential link between two syndromes with recurrent aphthous ulcers involved, BD and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome [ 19 , 28 – 31 ]. To the best of our knowledge, only one study on the potential role of vitamin D in RAS occurrence has been published to date [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status in recurrent aphthous stomatitis

Krawiecka¹,

Ślebioda²,

Szponar³

et al. 2017

pdia

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IntroductionRecurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease.AimTo evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism.Material and methodsSixty-six patients with RAS and 66 controls were examined. Immunomodulatory or immunosuppressive treatment and other ulcerative oral diseases were used as exclusion criteria. The severity of RAS was assessed according to the clinical classification of the disease, the number of lesions per flare-up and the length of intervals between the attacks. The serum vitamin D level was established in each participant.ResultsThe mean serum vitamin D (25(OH)D) levels were found to be 16.81 ng/ml in the study group and 19.22 ng/ml in the control group, with no statistically significant difference between the two groups. In the study group, 5 (7.6%) participants were diagnosed with the “normal” vitamin D levels, while 16 (24.2%) had “insufficient” levels and 45 (68.2%) had “deficient” levels. The corresponding distribution in the control group was 8 (12.1%), 18 (27.3%) and 40 (60.6%), respectively. There was no statistical significance in the difference of vitamin D deficits between the study and the control groups. No correlation was detected between the severity of RAS and the serum vitamin D level.ConclusionsVitamin D does not seem to be a trigger factor for RAS occurrence and does not appear to influence the severity of the disease in the studied group.

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Multiple brown tumor revealing primary hyperparathyroidism associated with Behçet’s disease: A case report

Jomaa¹,

Arfa²,

Boubaker³

et al. 2022

The Egyptian Rheumatologist

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Vitamin D levels in patients with Behçet’s disease: Significance and impact on disease measures

Cited by 12 publications

References 39 publications

High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet’s Disease

High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet’s Disease

Vitamin D status in recurrent aphthous stomatitis

Multiple brown tumor revealing primary hyperparathyroidism associated with Behçet’s disease: A case report

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