Vitamin D Levels in Infants With Biliary Atresia

Ng, Jessica; Paul, Anu; Wright, Naomi Jane; Hadžić, Nedim; Davenport, Mark

doi:10.1097/mpg.0000000000001074

Cited by 24 publications

(31 citation statements)

References 36 publications

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“…According to recent survey, VD deficiency accounts for 8–12% in healthy white infants and toddlers [13, 14]. In southern China, VD deficiency is 10.8% and insufficiency is 39% among children [15].…”

Section: Discussionmentioning

confidence: 99%

“…Fat-soluble vitamin (FSV) deficiency is extremely common in pre-KPE BA patients. VD deficiency alone accounts for 88–98% of pre-KPE BA patients, whereas nearly half of the patients present with two or more FSV deficiency [13, 22]. Even with successful KPE and oral supplementation of FSV, the prevalence of at least one FSV insufficiency in PKBA infants is 55% throughout six months after KPE; and the prevalence of FSV insufficiency in PKBA infants with persistent cholestasis six months after KPE is 100%, 80%, 50%, and 45%, respectively, for vitamins A, D, E, and K [23].…”

Section: Discussionmentioning

confidence: 99%

“…Bile acid secretion in the liver does not reach normal levels until 6 to 12 months after KPE is probably the main reason [22]. In addition, many studies show unsatisfactory repletion of serum 25-OHVD with enteral VD supplementations in PKBA patients, likely owing to inadequate intraluminal bile acids to solubilize orally administered VD [13, 23–25]. Many experts suggest higher doses of oral VD or parenteral VD supplements to overcome this difficulty.…”

Section: Discussionmentioning

confidence: 99%

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Serum vitamin D level is inversely associated with liver fibrosis in post Kasai’s portoenterostomy biliary atresia patients living with native liver

et al. 2019

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Objective This study aims to investigate the association of serum vitamin D (VD) levels with the severity of liver fibrosis (LF) in post Kasai’s portoenterostomy biliary atresia (PKBA) patients living with their native liver. Methods In this cross-sectional study, carried out in a tertiary Children’s Hospital in Taipei, Taiwan, PKBA patients living with their native liver were enrolled. Liver biochemistry data, serum 25-hydroxyvitamin D (25-OHVD), acoustic radiation force impulse (ARFI), and scores of Pediatric Quality of Life questionnaire (PedsQL) were collected. Results All the enrolled 33 PKBA patients (36.4% males), aged 1–23 years, possessed 25-OHVD less than 30ng/ml. An inverse correlation was detected between serum 25-OHVD and ARFI (r 2 = 0.175; p = 0.024). We selected a cutoff value of 23ng/mL to divide PKBA patients into two groups, as the p -value was the most significant at this point when comparing the median ARFI of two groups ( p = 0.003). Ten (30.3%) had 25-OHVD≥23ng/ml (HVD group), whereas 23(69.7%) had 25-OHVD<23ng/ml (LVD group). HVD group had lower ARFI (1.13m/s vs. 1.52m/s, p = 0.003), lower aspartate transaminase (AST) (29U/L vs. 64U/L, p = 0.033), and higher scores of self-reported health-related quality of life in psychosocial functioning (86.7 vs. 77.1, p = 0.047) than LVD group. Conclusion VD levels are inversely associated with severity of LF in PKBA patients with native liver.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum vitamin D level is inversely associated with liver fibrosis in post Kasai’s portoenterostomy biliary atresia patients living with native liver

et al. 2019

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“…To assess the status of VD deficiency, deficiency, insufficiency, and sufficiency were defined as serum 25-(OH)D levels of <10, 10-20, and >20 ng/ml, respectively [11]. Seasons were defined as spring (March, April, and May), summer (June, July, and August), autumn (September, October, and November), and winter (December, January, and February).…”

Section: Methodsmentioning

confidence: 99%

“…VD deficiency is frequent in BA patients [10, 11]. Although bile flow could be established after surgery, observation of VD deficiency in the majority of BA patients was confirmed [10], suggesting that VD deficiency contributes to the progression of liver function and liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia

Zhuang

Sun

Dong

et al. 2019

Gastroenterology Research and Practice

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Objectives To detail the effects of vitamin D (VD) deficiency and assess the relationships between VD deficiency and liver function and liver fibrosis in patients with biliary atresia (BA). Methods In this study, BA patients confirmed by intraoperative cholangiography were enrolled between January 2017 and February 2019. Preoperative serum 25-(OH)D level, liver function, serum biomarker levels of liver fibrosis, and histopathologic features were recorded. Deficiency, insufficiency, and sufficiency of VD were defined as serum 25-(OH)D concentrations of <10, 10-20, and >20 ng/ml, respectively. Associations between serum 25-(OH)D level and liver function and liver fibrosis were analyzed. Results A total of 161 BA infants were included. The median (interquartile range (IQR)) serum 25-(OH)D level in all patients was 7.56 (IQR: 4.48–11.40) ng/ml. The rates of 25-(OH)D deficiency, insufficiency, and sufficiency were 67.1% (108/161), 29.2% (47/161), and 3.7% (6/161), respectively. Serum 25-(OH)D level was negatively correlated with alkaline phosphatase (r = ‐0.232, P = 0.003). After adjusting for age, a decrease in serum 25-(OH)D level was correlated with the increase of the Batts-Ludwig stage score (odds ratio (OR): 0.94, 95% confidence interval (CI): 0.88–0.99; P = 0.028). Serum 25-(OH)D level was also correlated with the N-terminal propeptide of type III procollagen (PIIINP) (r = ‐0.246, P = 0.002). Additionally, PIIINP (P = 0.038) and ALP (P = 0.031) were independently associated with serum 25-(OH)D level. Conclusions VD deficiency was common and inversely correlated with liver fibrosis in BA patients. Furthermore, VD was not correlated with liver function except alkaline phosphatase.

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Biliary Atresia

Davenport¹

2018

Rickham's Neonatal Surgery

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Vitamin D Levels in Infants With Biliary Atresia

Cited by 24 publications

References 36 publications

Serum vitamin D level is inversely associated with liver fibrosis in post Kasai’s portoenterostomy biliary atresia patients living with native liver

Serum vitamin D level is inversely associated with liver fibrosis in post Kasai’s portoenterostomy biliary atresia patients living with native liver

Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia

Biliary Atresia

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