Vitamin D levels in children and adolescents with obsessive compulsive disorder

Yazıcı, Kemal Utku; Yazıcı, İpek Perçinel; Üstündağ, Bilal

doi:10.1080/08039488.2017.1406985

Cited by 20 publications

(27 citation statements)

References 57 publications

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“…On the other hand, Yazici et al showed no significant difference in vitamin D, calcium, phosphate and alkaline phosphatase levels between patients with OCD and healthy controls. But the level of vitamin D was negatively correlated with symptom severity in patients with OCD 21. This study has compared 60 patients with OCD and 60 healthy controls.…”

Section: Resultsmentioning

confidence: 96%

Nutritional and herbal supplements in the treatment of obsessive compulsive disorder

Karcı¹,

Çelik

2020

Gen Psych

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Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that is characterised by obsessions and compulsions. The recommended treatments for OCD are cognitive– behavioural therapy using exposure and response prevention and/or pharmacotherapy. On the other hand, some nutritional and herbal supplements may be effective in the treatment of OCD. Nutritional and herbal supplements in OCD treatment will be reviewed in this paper. PubMed (Medline), Cochrane Library and Google Scholar databases were reviewed for the topic. There are some supplements that have been researched in OCD treatment studies such as vitamin D, vitamin B12, folic acid, homocysteine, trace elements, N-acetyl cysteine, glycine, myoinositol, St John’s wort, milk thistle, valerian root, curcumin and borage. The effectiveness of herbal and nutritional supplements in the treatment of OCD should be supported with more conclusive evidence.

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Section: Resultsmentioning

confidence: 96%

Nutritional and herbal supplements in the treatment of obsessive compulsive disorder

Karcı¹,

Çelik

2020

Gen Psych

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“…Application of plasmapheresis may also lead to the stabilization of the basal ganglia volumes, which are altered during the disease [141,[203][204][205]. Since vitamin D metabolism has been observed to play a role in the pathogenesis of PANDAS, supplements of this vitamin can be useful in the reduction of psychiatric symptoms of patients [206,207].…”

Section: Other Treatment Strategiesmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the nervous system and gut microbiota, genetics, and the available treatment for PANDAS. Recent research indicates that PANDAS patients show noticeable alterations within the structures of the central nervous system, including caudate, putamen, globus pallidus, and striatum, as well as bilateral and lentiform nuclei. Likewise, the presence of autoantibodies that interact with basal ganglia was observed in PANDAS patients. Several studies also suggest a relationship between the presence of obsessive-compulsive disorders like PANDAS and alterations to the gut microbiota. Further, genetic predispositions—including variations in the MBL gene and TNF-α—seem to be relevant regarding PANDAS syndrome. Even though the literature is still scarce, the authors have attempted to provide a thorough insight into the PANDAS syndrome, bearing in mind the diagnostic difficulties of this condition.

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“…Their study included the use of the Yale-Brown Obsessive-Compulsive Scale to establish a correlation with vitamin D deficiency. Similarly, Yazici et al 19 employed a semistructured study to analyze patients with OCD. Vitamin D serum levels in patients with OCD were compared to controls, and lower amounts of vitamin D in the patient group with OCD were observed, although a significant difference between the groups was not apparent.…”

Section: Discussionmentioning

confidence: 99%

Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report

Titus-Lay

Eid²,

Kreys

et al. 2020

Mental Health Clinician

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Vitamin D deficiency has been correlated with non-scarring alopecia including alopecia areata or female pattern hair loss. It was theorized that hair loss secondary to vitamin D deficiency in patients susceptible to trichotillomania may exacerbate this obsessive-compulsive disorder. Though vitamin D deficiency is common, especially among patients suffering from neuropsychiatric disorders, its correlation with trichotillomania is not well reported. Two female patients suffering from trichotillomania defined by noticeable hair loss on the scalp through the Massachusetts General Hospital Hair Pulling Scale were treated to promote hair growth. Treatment included dietary supplementation with vitamin D3 1000 IU every day. It was found that in both patients treated with vitamin D3, marked improvements occurred over the span of 3 to 4 months. These included a reduction in obsessive compulsive disorder related hair loss as measured using the Massachusetts General Hospital Hair Pulling Scale, which correlated to their serum 25-hydroxyvitamin D levels. Experimental and clinical evidence is available to explain the underlying physiology and its probable relationship to trichotillomania's pathophysiology.

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Vitamin D levels in children and adolescents with obsessive compulsive disorder

Cited by 20 publications

References 57 publications

Nutritional and herbal supplements in the treatment of obsessive compulsive disorder

Nutritional and herbal supplements in the treatment of obsessive compulsive disorder

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report

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