Vitamin D Levels as a Neurosteroid Hormone Associated with the Developing of Catecholamines in Healthy Adults: A Clinical Study in a Group of Healthy Adult Women

Abstract

Vit D deficiency is a public health problem worldwide. According to epidemiological studies, low Vit D levels have been associated with an increased risk of certain neurodevelopmental disorders, including autism spectrum disorder, but the risk of high concentration of Vit D is not clearly affect in nervous system.. In this research, we studied whether vitamin D concentrations were associated with the activity of the nervous system in healthy people by comparing catecholamines concentrations in blood of 42 healthy women (age = 40-50 years old, body mass index: 22.7 ± 2.1 kg/m2). We had three groups as Vit D levels: (Deficient: vit D: ≤ 20 ng/L), (insufficient vita D 20-29 ng/L), (Sufficient vit D: ≥30≤70 ng/L). In our study:_ Plasma Noradrenaline decreased statistically significant ( p˂0.005) in high levels of vit D, _ Plasma Adrenaline increased statistically significant ( p˂0.005) in high levels of vit D,_ Plasma Dopamine increased statistically significant only in high levels of vitamin D. It should be mentioned that high levels of vita D has also been related to mood disorders, movement and a Calcium status. There was a statistical association between several measures of nervous system, hormones activity and vita D levels. This suggests that vita D induces catecholamine synthesis and/or secretion.