Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

Stroomberg, Hein Vincent; Vojdeman, Fie Juhl; Madsen, Christian; Helgstrand, John Thomas; Schwarz, Peter; Heegaard, Anne‐Marie; Olsen, Anja; Tjønneland, Anne; Lind, Bent; Brasso, Klaus; Jørgensen, Henrik L.; Røder, Martin Andreas

doi:10.1080/0284186x.2020.1837391

Cited by 23 publications

(19 citation statements)

References 23 publications

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“…Although other studies have shown that low concentrations of 25(OH)D increase the risk of mortality 33 direct comparisons are limited due to differences in clinical cut-points used in the categorization of 25(OH)D. In a recent study of Danish men serum vitamin D deficiency (<25 nmol/L; 10 ng/mL) compared to vitamin D sufficiency (50 – 75 nmol/L; 20 - 30 ng/mL) were associated with higher risk of PCa-specific mortality (HR: 2.37, 95%CI: 1.45-3.89, P < .001). 34 A study of 5-year survival of US veterans reported that 25(OH)D <20 ng/mL was strongly related to death from PCa. 35 Other long-term epidemiological studies of pre-diagnosis circulating 25(OH)D levels on mortality observed higher 25(OH)D concentrations predicted lower PCa-specific mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency was also associated poorer survival of men who died from all-cause mortality compared to men with sufficient 25(OH)D levels are consistent with other studies. 34 , 35 , 40 Studies of US veterans with PCa (1999-2012), showed that vitamin D deficiency reduced the likelihood of survival. 35 Similar findings were documented among a Norwegian cohort where a 25(OH)D of <50 nmol/L increased the risk of all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Deficiency at Diagnosis Increases All-Cause and Prostate Cancer-specific Mortality in Jamaican Men

et al. 2022

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Background 25 hydroxyvitamin D [25(OH)D] and serum calcium have been associated with incident prostate cancer (PCa). However, there is limited data on whether these metabolites predict survival in men of African descent, a population disproportionately affected by PCa. We studied the relationship of 25(OH)D at PCa diagnosis with all-cause and cancer-specific mortality among Jamaican men and examined whether serum calcium modified any associations. Methods Serum 25(OH)D from 152 Jamaican men with incident PCa within the Prostate Cancer Risk Evaluation (PROSCARE) study were re-evaluated approximately 11 years after enrollment. 25(OH)D analyses were stratified using the using Holick criteria. PCa-specific and all-cause mortality were examined in Kaplan–Meier survival curves and Cox regression models adjusted for age, body mass index (BMI), smoking and Gleason score. Restricted cubic splines evaluated nonlinear associations. Serum calcium was assessed as an effect modifier of the association between 25(OH)D and mortality. Results Of cases with available 25(OH)D, 64 men with PCa survived, 38 deaths were PCa specific and 36 died of other causes. At baseline, 9.9% of cases were vitamin D deficient and 61.2% were vitamin D sufficient. Compared to 25(OH)D sufficient men, those with 25(OH)D <20.0 ng/mL concentrations were associated with higher PCa-specific mortality (adjusted HR, 4.95; 95% CI, 1.68, 14.63, P = .004) and all-cause mortality (adjusted HR, 2.40; 95%CI, 1.33, 4. 32, P = .003). Serum calcium was not associated with survival and did not modify any associations with 25(OH)D. Conclusions 25(OH)D deficiency at PCa diagnosis predicted decreased survival for overall and PCa-specific cancer in Caribbean men of African ancestry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency at Diagnosis Increases All-Cause and Prostate Cancer-specific Mortality in Jamaican Men

et al. 2022

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“…Several epidemiologic trials confirmed that a low vitamin D status is also a risk factor for several types of cancer such as breast cancer [27], prostate cancer [28,29] and colorectal cancer [30] suggesting that vitamin D supplementation might be cancer preventive. Nevertheless, there are still conflicting data in this field, and large randomized control trials could not corroborate these findings for the general population.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria

Tulchiner

Staudacher

Fritz

et al. 2021

Cancers

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We conducted a retrospective National Cancer Registry study in Austria to assess a possible seasonal variation in the clinical diagnosis of testicular germ cell tumors (TGCT). In total, 3615 testicular cancer diagnoses were identified during an 11-year period from 2008 to 2018. Rate ratios for the monthly number of TGCT diagnoses, as well as of seasons and half-years, were assessed using a quasi-Poisson model. We identified, for the first time, a statistically significant seasonal trend (p < 0.001) in the frequency of monthly newly diagnosed cases of TGCT. In detail, clear seasonal variations with a reduction in the tumor incidence during the summer months (Apr–Sep) and an increase during the winter months (Oct–Mar) were observed (p < 0.001). Focusing on seasonality, the incidence during the months of Oct–Dec (p = 0.008) and Jan–Mar (p < 0.001) was significantly higher compared to the months of Jul–Sep, respectively. Regarding histopathological features, there is a predominating incidence in the winter months compared to summer months, mainly concerning pure seminomas (p < 0.001), but not the non-seminoma or mixed TGCT groups. In conclusion, the incidence of TGCT diagnoses in Austria has a strong seasonal pattern, with the highest rate during the winter months. These findings may be explained by a delay of self-referral during the summer months. However, the hypothetical influence of vitamin D3 in testicular carcinogenesis underlying seasonal changes in TGCT diagnosis should be the focus of further research.

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“…The confinement associated with the global pandemic has certainly played a key role in determining the serum VitD levels of patients with COVID-19 infection and solid neoplasms, such as colorectal, breast, lung, ovarian, bladder, prostate, and thyroid cancer. VitD levels, in addition to VRD polymorphisms, have proven to impact the outcomes of these patients [ 35 , 69 , 70 , 71 , 72 , 73 , 74 ]. However, studies have found contrasting results.…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

Innao

Allegra

Ginaldi

et al. 2021

IJMS

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Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bone marrow. In patients affected by multiple myeloma, vitamin D deficiency is commonly correlated with an advanced stage of the disease, greater risk of progression, the development of pathological fractures, and a worse prognosis. Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. However, in spite of the findings available in the literature, there is no clear standard of care and clinical practice varies. Further research is needed to better understand how vitamin D influences outcomes in patients with monoclonal gammopathies.

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Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

Cited by 23 publications

References 23 publications

Vitamin D Deficiency at Diagnosis Increases All-Cause and Prostate Cancer-specific Mortality in Jamaican Men

Vitamin D Deficiency at Diagnosis Increases All-Cause and Prostate Cancer-specific Mortality in Jamaican Men

Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

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