Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey

Matchar, David B.; Chei, Choy‐Lye; Yin, Zhaoxue; Koh, Victoria; Chakraborty, Bibhas; Shi, Xiaoming; Zeng, Yi

doi:10.1093/gerona/glw128

Cited by 48 publications

(35 citation statements)

References 41 publications

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“…5,7,8,16,27,[36][37][38][39][40][41] Eight studies reported vitamin D as a continuous variable, 5,6,10,27,29,36,39,42 27 as a categorical variable, and three reported both. Seventeen studies used a-priori cut offs 6,8,[14][15][16]28,34,35,37,41,[43][44][45][46][47][48][49] and 13 categorized into tertiles, 9,17,38,50,51 quartiles, 7,12,18,33 or quintiles. 13,40,52,53 The majority of studies analyzed serum 25OHD with four analyzing plasma 25OHD.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…13,40,52,53 The majority of studies analyzed serum 25OHD with four analyzing plasma 25OHD. 12,13,29,47 The most commonly reported vitamin D assays were the Dia Sorin radioimmune (n = 12) and liquid chromatography-tandem mass spectrometry (n = 10).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…While the involvement of vitamin D in musculoskeletal health is well‐established, associations with cognitive health have been identified . However, longitudinal evidence remains inconsistent, with some studies reporting cognitive decline related to vitamin D deficiency, whilst others failed to observe associations …”

mentioning

confidence: 99%

“…3,4 While the involvement of vitamin D in musculoskeletal health is well-established, associations with cognitive health have been identified. [5][6][7][8][9][10] However, longitudinal evidence remains inconsistent, with some studies reporting cognitive decline related to vitamin D deficiency, [11][12][13][14] whilst others failed to observe associations. [15][16][17][18] Previous reviews and meta-analyses 3,4,19,20 support the association between low vitamin D, poor cognition and risk of cognitive impairment or dementia, 21 however conclusions have been drawn from a small pool of studies (n ≤ 12).…”

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confidence: 99%

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A Systematic Review and Meta‐Analysis of The Effect of Low Vitamin D on Cognition

Goodwill

Szoeke

2017

J American Geriatrics Society

156

128

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Observational evidence demonstrates low vitamin D is related to poorer cognition; however, interventional studies are yet to show a clear benefit from vitamin D supplementation. From the evidence to date, there is likely a therapeutic age window relevant to the development of disease and therefore vitamin D therapy. Longitudinal lifespan studies are necessary to depict the optimal timing and duration in which repletion of vitamin D may protect against cognitive decline and dementia in aging, to better inform trials and practice towards a successful therapy.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A Systematic Review and Meta‐Analysis of The Effect of Low Vitamin D on Cognition

Goodwill

Szoeke

2017

J American Geriatrics Society

156

128

View full text Add to dashboard Cite

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“…60 Comparable findings were reported in China, where individuals with lower baseline vitamin D were 2 to 3 times more likely to have significant cognitive decline within 2 years compared to those with adequate levels. 61 …”

Section: Increased and Accelerated Cognitive Declinementioning

confidence: 99%

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

Alspach¹

2017

Critical Care Nurse

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Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment

Al-Amin

Bradford

Sullivan

et al. 2018

Human Brain Mapping

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Vitamin D deficiency may exacerbate adverse neurocognitive outcomes in the progression of diseases such as Parkinson's, Alzheimer's, and other dementias. Mild cognitive impairment (MCI) is prodromal for these neurocognitive disorders and neuroimaging studies suggest that, in the elderly, this cognitive impairment is associated with a reduction in hippocampal volume and white matter structural integrity. To test whether vitamin D is associated with neuroanatomical correlates of MCI, we analyzed an existing structural and diffusion MRI dataset of elderly patients with MCI. Based on serum 25‐OHD levels, patients were categorized into serum 25‐OHD deficient (<12 ng/mL, n = 27) or not‐deficient (>12 ng/mL, n = 29). Freesurfer 6.0 was used to parcellate the whole brain into 164 structures and segment the hippocampal subfields. Whole‐brain structural connectomes were generated using probabilistic tractography with MRtrix. The network‐based statistic (NBS) was used to identify subnetworks of connections that significantly differed between the groups. We found a significant reduction in total hippocampal volume in the serum 25‐OHD deficient group especially in the CA1, molecular layer, dentate gyrus, and fimbria. We observed a connection deficit in 13 regions with the right hippocampus at the center of the disrupted network. Our results demonstrate that low vitamin D is associated with reduced volumes of hippocampal subfields and connection deficits in elderly people with MCI, which may exacerbate neurocognitive outcomes. Longitudinal studies are now required to determine if vitamin D can serve as a biomarker for Alzheimer's disease and if intervention can prevent the progression from MCI to major cognitive disorders.

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Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey

Abstract: This first follow-up study of elderly people, including the oldest-old, in Asia shows that low vitamin D levels were associated with increased risk of subsequent cognitive decline and impairment.

Cited by 48 publications

References 41 publications

A Systematic Review and Meta‐Analysis of The Effect of Low Vitamin D on Cognition

A Systematic Review and Meta‐Analysis of The Effect of Low Vitamin D on Cognition

Vitamin D: Way More Important in Critical Care Than We May Have Recognized

Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment

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