Vitamin D Levels and Cardiopulmonary Status in Infants With Acute Bronchiolitis

Estalella-Mendoza, Ana; Castellano-Martínez, Ana; Flores-González, José Carlos; Estepa-Pedregosa, Lorena; Rodríguez-Campoy, Patricia; Rodríguez-González, Moisés

doi:10.1007/s13312-022-2519-0

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…They have concluded that low vitamin D levels were associated with clinical severity and impaired cardiopulmonary status in infants with acute bronchio-litis [1]. We have the following comment on their study [1].…”

Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 93%

“…We read with interest the recent article assessing the association of vitamin D deficiency (VDD) with cardiopulmonary status in infants with acute bronchiolitis [1]. They have concluded that low vitamin D levels were associated with clinical severity and impaired cardiopulmonary status in infants with acute bronchio-litis [1]. We have the following comment on their study [1].…”

Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 99%

“…Another issue we want to draw attention to is that the NIV was used with a high frequency of 25% in this study [1], but the details about the NIV methods are lacking. A meta-analysis of 15 studies [4] showed that high-flow nasal oxygen therapy is beneficial and safe, with similar failure rates with continuous positive airway pressure.…”

Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 99%

“…We think the differences in the prevalence of vitamin D deficiency (VDD), and vitamin D level cut-off points used to define VDD across studies could be the main reason for these conflicting results. Thus, the low incidence of VDD in studies showing no correlation between the severity of disease and vitamin D [1,2] is a significant limitation to consider when interpreting their results. Conversely, studies with larger sizes and higher rates of VDD [3,4] had conclusions similar to ours [1].…”

Section: Authors' Replymentioning

confidence: 99%

“…Thus, the low incidence of VDD in studies showing no correlation between the severity of disease and vitamin D [1,2] is a significant limitation to consider when interpreting their results. Conversely, studies with larger sizes and higher rates of VDD [3,4] had conclusions similar to ours [1]. We also agree with the comment about the relevance of age and prematurity on the severity of acute bronchiolitis.…”

Section: Authors' Replymentioning

confidence: 99%

See 4 more Smart Citations

Vitamin D Levels and Cardiopulmonary Status in Infants with Acute Bronchiolitis: Tip of the Iceberg?

Öztürk

Esquinas

2022

Indian Pediatr

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Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 93%

Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 99%

Section: C C C C O O O O O R R R R R R R R R R E E E E E S S S S S P ...mentioning

confidence: 99%

Section: Authors' Replymentioning

confidence: 99%

Section: Authors' Replymentioning

confidence: 99%

See 3 more Smart Citations

Vitamin D Levels and Cardiopulmonary Status in Infants with Acute Bronchiolitis: Tip of the Iceberg?

Öztürk

Esquinas

2022

Indian Pediatr

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Vitamin D and Respiratory Diseases

Goyal

2023

Indian J Pediatr

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Changes in T-Cell Subsets and Serum IFN-γ, IL-17, and IgE Levels in Children with Respiratory Syncytial Virus Capillary Bronchitis and Their Clinical Significance

Zhang

Luo

et al. 2022

Disease Markers

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Objective. To investigate the changes in T-cell subsets and serum IFN-γ, IL-17, and IgE levels in children with respiratory syncytial virus capillary bronchitis and their clinical significance. Methods. The clinical data of 50 children with respiratory syncytial virus capillary bronchitis admitted to our hospital between July 2020 and June 2021 were retrospectively reviewed, and they were included in the observation group, while 50 children with a healthy physical examination during the same period were chosen as the control group. The T-cell subsets (CD4, CD8, and CD4/CD8) and serum IL-4, IL-8, IFN-, IL-17, and IgE levels of children in the two groups were compared, and the clinical significance of the changes in the levels of the indices mentioned above was analyzed. Results. There was no statistically significant difference in T-cell subset levels (CD4 and CD8) between the two groups ( P > 0.05 ); the level of CD4/CD8, IL-4, IL-8, IL-17, and IgE in the observation group were substantially higher than those in the control group ( P < 0.05 ), while the serum IFN-γ levels in the observation group were significantly lower than those in the control group ( P < 0.05 ). Conclusion. Increased CD4/CD8 levels in children with respiratory syncytial virus capillary bronchitis cause an imbalance in the Th1/Th2 immune response, similar to changes in bronchial asthma, suggesting a link between the two diseases. Increased serum levels of IL-4, IL-8, IL-17, and IgE and decreased serum levels of IFN-γ have been seen in children with respiratory syncytial virus capillary bronchitis, suggesting the severity of the children’s disease may in part be reflected in the levels of the aforementioned serum indicators.

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Vitamin D Levels and Cardiopulmonary Status in Infants With Acute Bronchiolitis

Cited by 3 publications

References 15 publications

Vitamin D Levels and Cardiopulmonary Status in Infants with Acute Bronchiolitis: Tip of the Iceberg?

Vitamin D Levels and Cardiopulmonary Status in Infants with Acute Bronchiolitis: Tip of the Iceberg?

Vitamin D and Respiratory Diseases

Changes in T-Cell Subsets and Serum IFN-γ, IL-17, and IgE Levels in Children with Respiratory Syncytial Virus Capillary Bronchitis and Their Clinical Significance

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