Vitamin D Level in Multiple Sclerosis Patients. Could Vitamin D Level Be Routine Investigation for Multiple Sclerosis Patients?

Ibrahim, Mohamed Hamdy; Alloush, Taha Kamel; Rahim, Mohamed Khalid Abdul

doi:10.4236/nm.2014.55023

Cited by 7 publications

(10 citation statements)

References 18 publications

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“…A 5-ml blood sample was taken from all the subjects and the serum vitamin D levels were determined with a vitamin D total (25hydroxy vitamin D) kit using the electrochemiluminescence technique and then were be compared with healthy subjects. The normal laboratory ranges of the serum vitamin D if lower than 20 ng /ml were regarded as vitamin D deficiency, if serum vitamin D level between 20-30 ng /ml were regarded as insufficient vitamin D, the serum vitamin D level between 30-100 ng/ml were considered as sufficient vitamin D ,the level of vitamin D more than 100 ng/ml were considered as hyper-vitamin D [26].…”

Section: Methodsmentioning

confidence: 99%

The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study

Ahmed¹

2019

DJM

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Background: Lichen planus is an autoimmune chronic inflammatory condition of unknown etiology affecting stratified squamous epithelial. The cell-mediated immunity has a role in both developing oral lichen planus, and immune system regulation, that's why have role in the pathogenesis of oral lichen planus. The roles of vitamin D in an immune system and its anti-inflammatory effects have been indicated in recent study. Objective: To determine the level of serum vitamin D in patients with oral lichen planus and in compression with healthy subjects, and study the relation of serum vitamin D level with clinical types of oral lichen planus, symptom, and demography of oral lichen planus. Patients and Methods: Two group were designed in this case -control study, the first consist of 40 patients with oral Lichen planus, while the second is control group which include 40 healthy people. A 5-ml blood sample was taken from patients and healthy subjects. The serum vitamin D levels were assessed with a vitamin D total (25 -hydroxy vitamin D) kit by employing the electrochemiluminescence technique. Results: Oral lichen planus mostly affect middle age female, the most common type of oral lichen planus was reticular type (95%) followed by erosive (57.5%) and atrophic oral lichen planus (45%). Mostly oral lichen planus appears on buccal mucosa bilaterally (95%). Vitamin D deficiency was higher in patient with oral lichen planus (60%) and (22.5%) in control group. The control group has more insufficient vitamin D level (22.5%) as compared to oral lichen planus patient(OLP) (15%), which was statistically significant. The mean of vitamin D level in serum of patients with oral lichen planus were 18.84 ±12.69 ng/ml and in healthy subjects were 31.28 ± 13.58ng/ml, that was statistically significant (P< 0.001). Conclusion:The deficiency in serum vitamin D level was not only related to the development of oral lichen planus, but it was also related to the symptom, and types of oral lichen planus.

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Section: Methodsmentioning

confidence: 99%

The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study

Ahmed¹

2019

DJM

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“…Esperava-se que tanto o grupo controle quanto os pacientes com EM apresentassem níveis baixos de vitamina D, conforme estudos observados (Maeda et al, 2007;Saraiva et al, 2005). Entretanto, nossos resultados contradizem hipóteses sugeridas em outra avaliação (Smolders et al, 2008) (Ibrahim et al, 2014;Alves et al, 2013;Maryfran et al, 2009), porém, variando para insuficiência, enquanto a média do grupo EM encontra-se na insuficiência, variando para suficiência de vitamina D (>30-32 ng/ mL).…”

Section: Discussionunclassified

“…Assim, o trabalho permite traçar o perfil dos níveis de vitamina D em uma população exposta aos mesmos fatores ambientais. O ponto de corte para definir suficiência dos níveis séricos de vitamina D foi de >30 ng/mL (Ibrahim et al, 2014;Maryfran et al, 2009).…”

Section: Introductionunclassified

Relação Entre Capacidade Funcional E Qualidade De Vida De Pacientes Com Esclerose Lateral Amiotrófica

Santos¹,

Prudente²,

Siqueira³

et al. 2019

Avanços Na Neurologia E Na Sua Prática Clínica 2

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…Serum vitamin D levels were considered as "severe deficient" if the levels were lower than 10 ng /ml and levels from 10 to 20 ng /ml were considered "deficient", while between 20-30 ng /ml were considered "vitamin D insufficient" level. Serum vitamin D levels between 30-100 ng/ml were considered "normal" level and subjects with levels higher than 100 ng/ml were considered "hypervitamin D" (21). A comparison of vitamin D serum levels were done between healthy individuals and patients having either symptomatic or asymptomatic OLP.…”

Section: Serum Vitamin D Levelmentioning

confidence: 99%

“…A comparison of vitamin D serum levels were done between healthy individuals and patients having either symptomatic or asymptomatic OLP. Meanwhile, the distribution of vitamin D serum levels was done in group according to the classification of vitamin D serum levels (21).…”

Section: Serum Vitamin D Levelmentioning

confidence: 99%

Serum vitamin D level in healthy individuals versus patients with symptomatic and asymptomatic oral lichen planus

H¹,

Hussein²,

Sadek³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The aetiology of oral lichen planus (OLP) is multifactorial, having variable triggers. A role for vitamin D related to the immune system has been established. Vitamin D modulating effect is on the adaptive and innate immune responses. Our study aimed to compare serum levels of vitamin D in patients having different clinical symptoms of OLP (symptomatic or asymptomatic) with healthy individuals. Also, in this study, for further evaluation, the expression level of interleukin-17A and interleukin-6 (IL-17A and IL-6) was evaluated because the presence of active vitamin D reduces the expression of these proinflammatory factors. This study was included three groups with 30 volunteers in each. The first group included asymptomatic oral lichen planus patients (reticular or plaque-like lesions). The second group consisted of symptomatic oral lichen planus patients (atrophic or bullous-erosive lesions). In contrast, the third group consisted of healthy control subjects. The serum 25-hydroxyvitamin D was measured between the three groups and then correlated with clinical manifestation of oral lichen planus, either symptomatic or non-symptomatic. The Real-Time PCR technique was used to evaluate the expression of IL-17A and IL-6. Patients with symptomatic OLP (second group) had statistically significantly lower Vitamin D levels than asymptomatic OLP patients (first group). Healthy Controls (third group) exhibited statistically significantly higher vitamin D levels than OLP groups. The results of IL-17A and IL-6 genes expression showed that the presence of vitamin D had a statistically significant effect on reducing the expression of these two pro-inflammatory cytokines among symptomatic and asymptomatic OLP patients. Also, the results showed that there was a statistically significant difference between OLP patients (group I and II) and the control group (group III). In general, the current study results showed that lack of vitamin D had an important role in initiating or increasing the OLP's severity.

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Vitamin D Level in Multiple Sclerosis Patients. Could Vitamin D Level Be Routine Investigation for Multiple Sclerosis Patients?

Cited by 7 publications

References 18 publications

The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study

The Role of Serum Vitamin D Deficency in oral Lichen Planus Case Control Study

Relação Entre Capacidade Funcional E Qualidade De Vida De Pacientes Com Esclerose Lateral Amiotrófica

Serum vitamin D level in healthy individuals versus patients with symptomatic and asymptomatic oral lichen planus

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