Vitamin D Level in Children Is Correlated with Severity of Atopic Dermatitis but Only in Patients with Allergic Sensitizations

Akan, Ayşegül; Azkur, Dilek; Giniş, Tayfur; Toyran, Müge; Kaya, Ayşenur; Vezir, Emine; Özcan, Celal; Giniş, Zeynep; Kocabaş, Can Naci

doi:10.1111/pde.12058

Cited by 55 publications

(49 citation statements)

References 29 publications

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“…These results were consistent with epidemiological findings [29]. Akan et al [13] found the same relationship, especially in children with allergic sensitization, and the results of our study also support this finding. All of these data seem to indicate that VDD may be a risk factor for the development of AD.…”

Section: Discussionsupporting

confidence: 83%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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Section: Discussionsupporting

confidence: 83%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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“…This is in agreement with the study by other authors [12][13][14][15], who linked vitamin D deficiency to prevalence of AD and other allergic diseases.…”

Section: Discussionsupporting

confidence: 94%

“…In addition, we found that 66.7% of the AD patients had insufficient or deficient vitamin D; this is in accordance with the results of other studies [13][14][15] but with different percentages ranging from 61 to 82.5%. This variation in the percentages of patients with insufficient or deficient vitamin D may be due to the great variation in the clinical severity of AD in each study.…”

Section: Discussionsupporting

confidence: 94%

“…This is consistent with the studies by Ayman et al [13] and Shim et al [17], who found that the mean serum levels of vitamin D were significantly higher in patients with mild disease as compared with those with moderate or severe AD. This indicates that vitamin D may have different immunomodulating effects on the different inflammatory profiles of AD patients with and without allergen sensitization [15].…”

Section: Not Found Low Increased Significantly Increased Highmentioning

confidence: 99%

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Evaluation of 25-hydroxy vitamin D and specific immunoglobulin E to Staphylococcus aureus in patients with atopic dermatitis and their correlation with the disease severity

Elesawy¹,

Sabry²

2014

Journal of the Egyptian Womenʼs Dermatologic Society

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BackgroundAtopic dermatitis (AD) is an inflammatory, chronically relapsing, noncontagious and pruritic skin disorder. Vitamin D has major effects on the innate and adaptive immunity, which make the association between vitamin D and allergic diseases a field of interest. ObjectiveThe aim of the study was to estimate the serum level of 25-hydroxy vitamin D [25(OH)D] concentration and specific immunoglobulin E (IgE) to Staphylococcus aureus in patients with AD and their correlation with disease severity. Patients and methods Thirty patients were enrolled in this case-control study. Diagnosis of AD was made according to the UK Working Party diagnostic criteria for AD. Disease severity determination by SCORAD index and measurement of 25(OH)D and specific IgE to S. aureus in the sera of the patients were performed. Twenty age-matched and sexmatched apparently healthy individuals were also included in the study as controls. ResultsThe mean value of 25(OH)D was significantly lower in the AD patients group compared with the control group, and 66.7% of the AD patients had insufficient or deficient vitamin D. In this study, an inverse correlation between serum concentrations of 25(OH)D and the severity of disease was found. The mean value of specific IgE to S. aureus was significantly increased in patients than in controls. There was a significant correlation between specific IgE to S. aureus and the severity of AD and an inverse correlation between serum 25(OH)D levels and IgE to S. aureus. Conclusion Vitamin D may be insufficient or deficient in a subset of AD children, especially those with moderate and severe disease; these patients were sensitive to S. aureus.

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“…Bazı çalışmalarda, D vitamini seviyesi ile atopik dermatit prevalansı ve/veya şiddeti arasında negatif ilişki olduğu savunulmakta, vitamin D düşüklüğünün alerjik sensitizasyonu ve/veya şiddetli hastalığı olanlarda daha belirgin olduğu gözlenmiştir (62). Göz-lemsel olarak, güneşin az olduğu dönemde hastalık prevalansının sıklığı bilinir.…”

Section: Atopik Dermatit İlişkisiunclassified

Untitled

2015

JAREM

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Vitamin D is a steroid hormone that has important effects on bone metabolism and neuromuscular functions. Recent research has indicated that it also has a role in the development and treatment of allergic diseases by affecting the immune system through different mechanisms. After vitamin D is activated by liver and kidney in the body, it shows its effect by attaching to its receptor on the cell membrane. The vitamin D receptor is expressed on all tissue cells, particularly on those of the respiratory and intestinal epithelium by which extra-skeletal functions of vitamin D such as anti-inflammatory effects and immunomodulation are mediated. As a consequence, it is assumed that vitamin D and its receptor have effects on various systems in the human body. Some researchers suggest that deficiency or excess of vitamin D in the diet causes an increase in asthma and allergic diseases. Therefore, vitamin D supplementation is currently advised by some authors for the prevention and treatment of allergic diseases. It has commonly been reported that vitamin D is particularly found to be useful in preventing asthma attack and in managing resistant asthma. Currently, there has been an increase in the literature regarding the role of vitamin D in the treatment of atopic dermatitis and chronic urticaria-angioedema.

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Vitamin D Level in Children Is Correlated with Severity of Atopic Dermatitis but Only in Patients with Allergic Sensitizations

Cited by 55 publications

References 29 publications

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Evaluation of 25-hydroxy vitamin D and specific immunoglobulin E to Staphylococcus aureus in patients with atopic dermatitis and their correlation with the disease severity

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