Vitamin D, Its Role in Recovery after Muscular Damage Following Exercise

Caballero-García, Alberto; Córdova-Martínez, Alfredo; Vicente-Salar, Néstor; Roche, Enrique; Pérez-Valdecantos, Daniel

doi:10.3390/nu13072336

Cited by 13 publications

(6 citation statements)

References 94 publications

(135 reference statements)

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“…We interpret this as a subjective assessment derived both from the reduction in the inflammatory process and from the patients' care, rather than from the treatment itself. In our study, we achieved an increase in serum levels of 25-OH vitamin D, which, according to the literature, could counteract the imbalance of some of the components of coronavirus infection and also manifest their own anti-inflammatory effects [35]. This speculative interpretation needs further research.…”

Section: Discussionsupporting

confidence: 59%

“…As we have communicated previously in a review, despite the evident benefit of vitamin D in muscle function, particularly in recovery from inflammation caused by exercise, it seems that musculoskeletal benefits occur when deficient or insufficient circulating levels of vitamin D (20-30 ng/mL) are restored [35]. At the end of our study, the levels of 25-OH vitamin D (VD group) were higher than 30 (31.32 ± 1.42).…”

Section: Discussionmentioning

confidence: 47%

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Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

Caballero-García

Pérez-Valdecantos

Guallar³

et al. 2021

Medicina

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Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection. Materials and Methods: This pilot study was conducted at the Soria Norte Health Center. The study consisted of a double-blind trial with two groups of men (placebo and vitamin D-supplemented) (n = 15/group). Treatment with vitamin D (cholecalciferol: 2000 IU/day) and placebo was carried out for 6 weeks. Circulating hematological and biochemical parameters (total protein, glucose, vitamin D, urea, uric acid, aspartate aminotransferase/glutamic-oxaloacetic transaminase, alanine aminotransferase/glutamic-pyruvic transaminase, creatine kinase, lactate dehydrogenase, aldolase, gamma-glutamyl transferase and myoglobin) and the hormones cortisol and testosterone were determined. As for respiratory function tests, FEV1 and respiratory flow were also studied. For physical fitness tests, the “six-minute walk test” (6MWT) was used. Results: After vitamin D supplementation, we observed that serum creatine kinase levels returned to optimal values. This change suggests a protective role of vitamin D against muscle catabolism compared to placebo. In terms of physical test results, we observed only slight non-significant improvements, although patients reported feeling better. Conclusions: Vitamin D supplementation produces decreases in indicators of muscle damage, which may ultimately contribute to improving the health status and quality of life of patients who have suffered from COVID-19, during the recovery process.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 47%

Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

Caballero-García

Pérez-Valdecantos

Guallar³

et al. 2021

Medicina

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“…Furthermore, it was recently shown that through specific signaling pathways, VitD would also be involved in glucose metabolism, in mitochondrial activity and in the production of energy needed to maintain muscle health [42,43]. In the postexercise period, vitD as well seems to act helping muscle recovery through its anti inflammatory properties, reducing the synthesis of pro-inflammatory cytokines such as IL-2 and TNF-α that occur in response to physical activity [44].…”

Section: Discussionmentioning

confidence: 99%

A Review of Clinical Trials about Vitamin D Supplementation's Effect on Physical Performance of Community Dwelling Oldest-Olds

Paixão¹,

Santos²,

Amarante³

et al. 2022

J Geriatr Med Gerontol

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Background: Although observational studies with community dwelling older adults demonstrate that low serum 25(OH)D (vitD) negatively impacts on the health, the effects of its supplementation are still controversial. The aim of this study is to review clinical trials that evaluated the effect of vitD supplementation on physical performance in community dwelling oldest old.Methods: A comprehensive search on electronic databases, including Pubmed, Medline, LILACS and Scielo was conducted. Eligible studies were clinical trials published between January 2015 and June 2021 in Portuguese, English and Spanish. The selected articles should meet the following inclusion criteria: Included elderlies aged 80 and over, independent, community-dwelling and of both sexes. Experimental studies with dependent elderly, institutionalized, hospitalized, diagnosed with dementia, acute and/or severe diseases were excluded.Results: Out of the 11533 articles from the literature search, 21 studies met the inclusion criteria. The results suggest that vitD supplementation alone in most studies does not improve physical performance, even in populations at higher risk (elderly people with insufficiency or deficiency of this vitamin, pre-frailty and frailty, functional impairment and advanced age). When combined with resistance exercise and with other nutrients that are also important for muscle health, there seems to be an improvement in physical tests. However, the heterogeneity of the studies carried out so far contribute to still contradictory results. Conclusion:Although vitD supplementation corresponds to a potential therapy to prevent physical decline in the elderly, studies with the Brazilian population will be needed to better clarify these effects in community dwelling oldest old.

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“…In a meta-analysis about the effects of Vitamin D in post-exercise muscle recovery, we observed [21] that although vitamin D seems to be effective against the muscular inflammatory process, the role in post-exercise recovery by modulating the release of muscle biomarkers remains to be demonstrated [22]. We suggest that following investigations include cytokine determinations, and the use of a longer administration time or higher doses of supplementation would be variables to take into account.…”

Section: Introductionmentioning

confidence: 94%