Vitamin D is negatively associated with triglyceride in overweight/obese patients with type 2 diabetes

Gong, Tong; Di, Hongjie; Han, Xue; Hu, Xin; Liu, Chao; Chen, Guofang

doi:10.1007/s12020-022-03009-8

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…HDL-C was lower and TGs were higher in the hypovitaminosis D group [ 21 ]. Similar positive associations have been observed in numerous other studies conducted across various populations [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. A recent cross-sectional study confirmed that the percentage of individuals with dyslipidemia and dysglycemia was higher in subjects with low levels of vitamin D [ 33 ].…”

Section: Resultssupporting

confidence: 89%

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Al Refaie,

Baldassini,

Mondillo

et al. 2024

Nutrients

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Nowadays, the interest in the extraskeletal effects of vitamin D is growing. In the literature, its several possible actions have been confirmed. Vitamin D seems to have a regulatory role in many different fields—inflammation, immunity, and the endocrine system—and many studies would demonstrate a possible correlation between vitamin D and cardiovascular disease. In this paper, we deepened the relationship between vitamin D and dyslipidemia by reviewing the available literature. The results are not entirely clear-cut: on the one hand, numerous observational studies suggest a link between higher serum vitamin D levels and a beneficial lipid profile, while on the other hand, interventional studies do not demonstrate a significant effect. Understanding the possible relationship between vitamin D and dyslipidemia may represent a turning point: another link between vitamin D and the cardiovascular system.

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Section: Resultssupporting

confidence: 89%

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Al Refaie,

Baldassini,

Mondillo

et al. 2024

Nutrients

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“…This positive influence of 25(OH)D on HDL-C might result from the increased concentration of apolipoprotein AI in the blood, which plays an important role in the reverse cholesterol transport process (Kazlauskaite et al 2010). Pearson's correlation revealed a significant negative correlation between serum TG and 25(OH)D, which is similar to the findings of some other studies (Elmi et al 2021;Elshebiny et al 2021;Gong et al 2022). In contrast to this finding, Ramiro-Lozano and Calvo-Romero (2015) concluded that supplementing T2DM patients with 16,000 IU of vitamin D once a week for eight weeks did not significantly alter their blood TG, cholesterol, and HDL levels.…”

Section: Discussionsupporting

confidence: 87%

Beneficial effects of vitamin D in the management of untreated hyperlipidemia in diabetic patients in Erbil, Iraq

Khoshnaw¹,

Dizaye²

2022

PHAR

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Hyperlipidemia is highly prevalent among type 2 diabetes mellitus (T2DM) patients. As hyperlipidemia plays a major part in atherosclerosis development and progression, this occurrence is linked to a significantly raised risk of cardiovascular disease. This study aims to assess the effects of vitamin D supplementation on lipid parameters in T2DM patients with untreated hyperlipidemia. Thirty-five T2DM patients with hyperlipidemia and vitamin D deficiency were supplemented with vitamin D for three months. Serum 25-hydroxyvitamin D (25[OH]D), calcium, lipid parameters, atherogenic indices, glucose, and HbA1c were recorded before and after the intervention. After supplementation, there was a statistically significant reduction in VLDL-C and triglycerides. Triglycerides showed a significant negative correlation with 25(OH)D. Atherogenic indices and HDL-C also improved significantly. Vitamin D supplementation had beneficial effects on the lipid profile of T2DM patients with untreated hyperlipidemia and vitamin D deficiency. Thus, vitamin D could be a valuable adjuvant therapy for these patients.

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“…1 ). The detailed characteristics of the 21 eligible studies [ 20 – 22 , 27 – 44 ] are shown in Table 1 . Among the 21 studies included in this analysis, 3 studies were performed in China; 3, in the USA; 4, in Italy; 1, in Turkey; 1, in Spain; 3, in Brazil; 1, in Australia; 1, in Poland; 1, in Ajman; 2, in Iran; and 1 in United Arab Emirates (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the included 12 studies, we found that there were different results in various populations. Interestingly, two included studies [ 33 , 44 ] conducted in the persons with obesity and type 2 diabetes has the correlation coefficients which reached the statistical significance. Additionally, all the three studies performed in the women with obesity [ 28 , 34 , 37 ] demonstrated that the significant inverse association between serum 25(OH)D and triglycerides was existed, while other lipid profiles including TC, LDL and HDL showed no statistical significance.…”

Section: Resultsmentioning

confidence: 99%

Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis

Huang,

Yang,

Jiang

et al. 2023

BMC Public Health

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Objective The association between vitamin D deficiency and lipid profiles in adults with overweight or obesity remains unclear and inconsistent. The aim of our study was to determine the relationship between lipid profiles and vitamin D deficiency in the overweight and obese adults. Methods Four databases, including PubMed, the Web of Science, EMBASE and the Cochrane Library, were used to identify all studies on vitamin D status and lipid levels, including the serum levels of triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). The Weighted mean difference (WMD) with 95% confidence intervals (CIs) using random-effects models was used to assess the association between the lipid profile and vitamin D deficiency. Results Twenty-one articles that included a total of 7952 adults with overweight or obesity (BMI ≥ 25 kg/m2) were included. The overall results revealed that compared with the controls, individuals with vitamin D deficiency showed higher levels of TG (WMD = 15.01; 95%CI, 2.51–27.52) and TC (WMD = 8.61; 95%CI, 1.31–15.92). Moreover, vitamin D deficiency was related to an increased level of LDL (WMD = 6.12; 95%CI, 0.02–12.23). HDL level was inversely associated with the vitamin D deficiency status (WMD = -2.57; 95%CI, -4.26, -0.88). Conclusions Among the adults with overweight or obesity, the vitamin D deficient group displayed impaired lipid profiles, including increased TG, TC and LDL levels and reduced HDL level.

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Vitamin D is negatively associated with triglyceride in overweight/obese patients with type 2 diabetes

Cited by 8 publications

References 29 publications

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Beneficial effects of vitamin D in the management of untreated hyperlipidemia in diabetic patients in Erbil, Iraq

Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis

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Vitamin D is negatively associated with triglyceride in overweight/obese patients with type 2 diabetes

Cited by 8 publications

References 29 publications

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

﻿Beneficial effects of vitamin D in the management of untreated hyperlipidemia in diabetic patients in Erbil, Iraq

Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis

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Beneficial effects of vitamin D in the management of untreated hyperlipidemia in diabetic patients in Erbil, Iraq