Vitamin D involvement in rheumatoid arthritis and systemic lupus erythaematosus

Cutolo, Maurizio; Otsa, Kati; Paolino, Sabrina; Yprus, M; Veldi, T; Seriolo, Bruno

doi:10.1136/ard.2008.093476

Cited by 93 publications

(53 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Identification of vitamin D deficiency is important not only in healthy subjects but also in patients with inflammatory arthritis, as vitamin D deficiency is linked to the development of several autoimmune disorders such as SLE, RA, Behcest's polymyositis/dermatomyositis, and systemic sclerosis [1,4,6]. Furthermore, low serum 25-OHD correlates with disease severity in patients such as RA and inflammatory polyarthritis [17,18,20].…”

Section: Discussionmentioning

confidence: 98%

“…There is a growing body of evidence that vitamin D is important in the initiation and propagation of a range of autoimmune diseases [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D may be involved in the pathogenesis and/or progression of several disorders, including cancer, hypertension, cardiovascular disease, neuromuscular diseases, osteoarthritis, diabetes, and other autoimmune diseases [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls

2011

View full text Add to dashboard Cite

Inadequate vitamin D may be involved in the pathogenesis and or progression of several disorders, including connective tissue diseases. To determine the status of vitamin D in different stages of inflammatory arthritis, the levels of vitamin D in established rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (UIA) were compared with controls. Patients with RA and UIA entered the study. Serum 25-hydroxyvitamin D (25-OHD) was measured by ELISA method, and concentrations less than 20 ng/ml were considered as deficient levels. In statistical analysis, the Mann-Whitney U test was used for comparing differences between groups and logistic regression analysis with calculation of adjusted odds ratio (OR) was used to determine the association between serum 25-OHD deficiency and disease condition. A total of 108 RA, 39 UIA, and 239 controls were studied. There were no significant differences in mean serum 25-OHD level and frequency of serum 25-OHD deficiency between RA and controls (37 ± 37.7 vs. 33.2 ± 28.6 ng/ml, P = 0.96). But the mean serum 25-OHD level in UIA was significantly lower than in the controls (25.1 ± 23.9 vs. 33.2 ± 28.6 ng ml, P = 0.04). A significant positive association was observed between serum 25-OHD deficiency and UIA (56.4% vs. 35.5%, OR = 2.34, 95% CI, 1.18-4.65, P = 0.021) which remained significant after adjustment for sex and age (adjusted OR = 2.24, 95% CI, 1.01-4.55, P = 0.026). Whereas the association between serum 25-OHD deficiency and RA did not reach statistical significance (40.7% vs. 35.5%, OR = 1.24, 95% CI, 0.78-1.99). These findings indicate higher serum vitamin D deficiency in patients with ongoing arthritis rather than established arthritis. Respecting to deleterious effects of vitamin D deficiency on immune system and progressive nature of UIA, a significant proportion of high risk UIA can be recognized by serum 25-OHD determination.

show abstract

Section: Discussionmentioning

confidence: 98%

“…There is a growing body of evidence that vitamin D is important in the initiation and propagation of a range of autoimmune diseases [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls

2011

View full text Add to dashboard Cite

show abstract

“…4,[7][8][9][10][11][12] Previous studies have shown a high prevalence of vitamin D deficiency in adult lupus with approximately one-fifth of patients having severe deficiency. [13][14][15][16] Nevertheless, the association of hypovitaminosis D and SLE activity remains controversial with some studies demonstrating an inverse relationship between SLE activity and serum vitamin D concentration, [17][18][19][20][21][22] while others did not find this association. [23][24][25][26] The role of vitamin D in bone health is known to be important in the general population 27 however this association was not observed in adult SLE patients.…”

Section: Introductionmentioning

confidence: 99%

Juvenile onset systemic lupus erythematosus: a possible role for vitamin D in disease status and bone health

Casella

Seguro

Takayama

et al. 2012

Lupus

View full text Add to dashboard Cite

Purpose: In juvenile onset systemic lupus erythematosus (JoSLE), evidence for the association between vitamin D status, lupus activity, and bone health is very limited and not conclusive. The aim of this study was, therefore, to assess in JoSLE patients the possible relevance of vitamin D deficiency in disease and bone parameters. Methods: Fifty-seven JoSLE patients were initially compared to 37 age, race and body mass index (BMI) -matched healthy controls. The serum concentration of 25 hydroxyvitamin D (25OHD) was determined by radioimmunoassay. Patients with 25OHD deficiency ( 20 ng/mL) were compared to those with levels >20 ng/mL. Disease activity was evaluated by SLE Disease Activity Index (SLEDAI). Bone mineral density (BMD) and body composition (BC) were measured using dual-energy X-ray absorptiometry (DXA). Results: 25OHD levels were similar in patients and controls (21.44 AE 7.91 vs 22.54 AE 8.25 ng/mL, p ¼ 0.519), regardless of supplementation (65% of patients and none in controls). Thirty-one patients with 25OHD deficiency ( 20 ng/mL) were further compared to the 26 JoSLE patients with levels >20 ng/mL. These two groups were well-balanced regarding vitamin D confounding variables: age (p ¼ 0.

show abstract

“…These findings could relate to the photosensitivity associated with these conditions and the special recommendation to use sunscreen and avoid sun exposure. Other possibilities include associated renal disease or medications 15,23,41 . Hence, patients with SLE and MCTD may be at increased risk for vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 99%

25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls

Pelajo

Lopez-Benitez²,

Miller³

2011

J Rheumatol

View full text Add to dashboard Cite

show abstract

Vitamin D involvement in rheumatoid arthritis and systemic lupus erythaematosus

Cited by 93 publications

References 9 publications

The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls

The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls

Juvenile onset systemic lupus erythematosus: a possible role for vitamin D in disease status and bone health

25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls

Contact Info

Product

Resources

About