Vitamin D Intake and Risk of Incident Hypertension

Forman, John P.; Bischoff‐Ferrari, Heike A.; Willett, Walter C.; Stampfer, Meir J.; Curhan, Gary C.

doi:10.1161/01.hyp.0000182662.82666.37

Cited by 119 publications

(37 citation statements)

References 31 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[52][53][54] It is slightly more clear whether supplementation of Vit D decreases arterial pressure. 55,56 In our study, SBP and DBP levels were higher in individuals with MS than without MS. Moreover both systolic and diastolic blood pressure levels reduced as Vit D levels increased.…”

Section: Resultssupporting

confidence: 45%

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Evrim¹,

Atalay²,

Gürsoy³

et al. 2016

Turkiye Klinikleri J Endocrin

View full text Add to dashboard Cite

A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : Hypovitaminosis D and metabolic syndrome are worldwide common problems. The link between them was unresolved. We planned to define the relation between Vitamin D levels and metabolic syndrome and also their parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We evaluated all the demographic and anthropometric parameters of 79 healthy participants and 95 patients with metabolic syndrome and compared those parameters and vitamin D levels. We classified 25(OH)D serum levels; <10ng/mL as serious deficiency, 10-20 ng/mL as deficiency, 20-30 ng/mL insufficiency and > 30 ng/mL as normal status. We searched the correlation of vitamin D levels with metabolic syndrome parameters. We also examined the relation of various Vitamin D levels with demographic and anthropometric findings of metabolic syndrome patients. R Re es su ul lt ts s: : Vitamin D levels were low in all the individuals (12.8 ± 6.7ng/mL in patients and 19.0 ± 10.0ng/mL in controls. p<0.001). In metabolic syndrome patients, serious deficiency was high and normal Vit D status was significantly low especially in females. In metabolic syndrome group vitamin D levels were negatively correlated with body mass index, waist circumference, blood glucose, hemoglobin A1c, fasting insulin, insulin resistance index (p <0.012, <0.040, <0.002, <0.008, <0.006, <0.001 respectively). We found that vitamin D levels of the patients without hypertension, diabetes mellitus, dyslipidemia or obesity were higher than that of the patients with those diseases among metabolic syndrome group (all p<0.001). We also demonstrated as Vitamin D levels decreased, rate of obesity, hypertension and diabetes mellitus increased, (p<.0.029, <0.035 and <0.001 respectively). C Co on nc cl lu us si io on n: : In patients with metabolic syndrome hypovitaminosis D is frequent especially in women. As Vitamin D levels are in negative correlation with obesity, diabetes and insulin resistance indices and also with metabolic syndrome parameters, we concluded that Vitamin D supplementation is important in hypovitaminosis D cases with metabolic syndrome. Ya zış ma Ad re si/Cor res pon den ce:

show abstract

Section: Resultssupporting

confidence: 45%

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Evrim¹,

Atalay²,

Gürsoy³

et al. 2016

Turkiye Klinikleri J Endocrin

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have demonstrated the independent association between vitamin D deficiency and CVD risk factors, such as hypertension [2], diabetes mellitus [3], obesity [4], metabolic syndrome [5], subclinical atherosclerosis (intima-media thickness [IMT]) [6], and coronary calcification [7,8]. Hypovitaminosis D has also been associated with cardiovascular events, such as MI [9], congestive heart failure, sudden cardiac death [10] and total mortality [11].…”

Section: Beata Goleniewska Et Al Vitamin D and Coronary Angiogram Imentioning

confidence: 99%

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

2013

View full text Add to dashboard Cite

show abstract

“…10 mg/d. Results from three large prospective studies, Nurses' Health Study I (n 77 436), Nurses' Health Study II (n 93, 803) and the Health Professionals Follow-up Study (n 38 074), found no evidence that a higher intake of vitamin D reduced (or increased) the risk of incident hypertension after multiple adjustments and approaches to the analysis (129) . Diagnosis of hypertension in this study was self-reported, and although self-reported hypertension in a health professionals' study is reasonably reliable, it does cast doubt over the study outcomes.…”

Section: Elevated Blood Pressurementioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

View full text Add to dashboard Cite

The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

show abstract

Vitamin D Intake and Risk of Incident Hypertension

Cited by 119 publications

References 31 publications

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

Vitamin D and cardiometabolic health: a review of the evidence

Contact Info

Product

Resources

About